Marc van Oostrum
@marcvoo.bsky.social
molecular systems biology of the synapse | snsf ambizione | spatial proteomics | molecular neuroscience
https://bit.ly/MvO
https://bit.ly/MvO
Reposted by Marc van Oostrum
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠
We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪
www.biorxiv.org/content/10.6...
🧵 1/5
We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪
www.biorxiv.org/content/10.6...
🧵 1/5
September 30, 2026 at 9:33 AM
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠
We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪
www.biorxiv.org/content/10.6...
🧵 1/5
We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪
www.biorxiv.org/content/10.6...
🧵 1/5
Reposted by Marc van Oostrum
🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027.
www.ucl.ac.uk/news/2026/ap...
www.ucl.ac.uk/news/2026/ap...
April 29, 2026 at 12:35 PM
🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027.
www.ucl.ac.uk/news/2026/ap...
www.ucl.ac.uk/news/2026/ap...
Reposted by Marc van Oostrum
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org
April 13, 2026 at 4:51 AM
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
Reposted by Marc van Oostrum
We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research!
otto-naegeli-preis.ch
otto-naegeli-preis.ch
April 7, 2026 at 4:17 PM
We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research!
otto-naegeli-preis.ch
otto-naegeli-preis.ch
Reposted by Marc van Oostrum
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
February 19, 2026 at 7:09 PM
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
Reposted by Marc van Oostrum
Autismus - Neuronale Besonderheiten und neue Behandlungswege
#EinblickeBiozentrum by @scheiffelelab.bsky.social
December 16, 2025.
Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird.
ow.ly/Wkme50RbjZc
#EinblickeBiozentrum by @scheiffelelab.bsky.social
December 16, 2025.
Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird.
ow.ly/Wkme50RbjZc
December 2, 2025 at 11:13 AM
Autismus - Neuronale Besonderheiten und neue Behandlungswege
#EinblickeBiozentrum by @scheiffelelab.bsky.social
December 16, 2025.
Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird.
ow.ly/Wkme50RbjZc
#EinblickeBiozentrum by @scheiffelelab.bsky.social
December 16, 2025.
Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird.
ow.ly/Wkme50RbjZc
Reposted by Marc van Oostrum
Thank you to 250+ participants, our keynote speakers, and the Event Forum team for an inspiring Swiss Dementia Forum.
November 10, 2025 at 8:33 AM
Thank you to 250+ participants, our keynote speakers, and the Event Forum team for an inspiring Swiss Dementia Forum.
Reposted by Marc van Oostrum
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
September 19, 2025 at 6:07 PM
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
Reposted by Marc van Oostrum
🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social #neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P
Erin M. Schuman Wins 2026 Nakasone Award
bit.ly
July 10, 2025 at 12:00 PM
🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social #neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P
Reposted by Marc van Oostrum
Congratulations! The new Advanced Grant winners are great news.
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!
📣 Good news: 281 top researchers have just won ERC Advanced Grants!
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
June 17, 2025 at 9:53 PM
Congratulations! The new Advanced Grant winners are great news.
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!
But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!
Reposted by Marc van Oostrum
We are accepting applications for a PhD opportunity at @scilifelab.se
this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.
A EU funded generous fellowship is offered with possibility of industry experience. Apply here:
this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.
A EU funded generous fellowship is offered with possibility of industry experience. Apply here:
PhD project in METABOLIC REGULATION OF GENOME FUNCTION AND CELL IDENTITY – Ilaria Piazza Laboratory
thewittysquare.eu
June 17, 2025 at 3:10 PM
We are accepting applications for a PhD opportunity at @scilifelab.se
this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.
A EU funded generous fellowship is offered with possibility of industry experience. Apply here:
this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.
A EU funded generous fellowship is offered with possibility of industry experience. Apply here:
Reposted by Marc van Oostrum
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
www.sciencedirect.com
June 11, 2025 at 11:34 AM
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Reposted by Marc van Oostrum
"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt...
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence
May 23, 2025 at 8:24 AM
"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt...
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence
This one is for all the #ChandelierNeuron fans out there
#sciArt #sciComm #neuroscience #neuroskyence
Reposted by Marc van Oostrum
🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025!
🎉Congratulations to all other prize winners！
👏 Warm congratulations to the organizers on the successful completion of the event!
#proteomes #proteomics
🎉Congratulations to all other prize winners！
👏 Warm congratulations to the organizers on the successful completion of the event!
#proteomes #proteomics
May 22, 2025 at 10:58 AM
🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025!
🎉Congratulations to all other prize winners！
👏 Warm congratulations to the organizers on the successful completion of the event!
#proteomes #proteomics
🎉Congratulations to all other prize winners！
👏 Warm congratulations to the organizers on the successful completion of the event!
#proteomes #proteomics
Reposted by Marc van Oostrum
Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
May 20, 2025 at 7:14 AM
Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
Reposted by Marc van Oostrum
We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.
Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...
www.biorxiv.org
May 13, 2025 at 9:49 AM
We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marc van Oostrum
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
go.nature.com
May 2, 2025 at 3:49 PM
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM
Reposted by Marc van Oostrum
Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...
Understanding which proteins work together
Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing...
ethz.ch
May 12, 2025 at 5:53 AM
Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...
Reposted by Marc van Oostrum
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 2, 2025 at 10:31 AM
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marc van Oostrum
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
April 28, 2025 at 3:08 PM
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
Proteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi...
www.biorxiv.org
April 28, 2025 at 9:24 AM
50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social !
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marc van Oostrum
On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.
First study from the lab is out! We describe ApuRs, a new family of microbial rhodopsins unique from apusomonads. ApuRs represent the first anion-conducting rhodopsin channels that can be controlled by UV light, offering potential as new optogenetic tools. #protistsonsky
doi.org/10.1101/2025...
👇
doi.org/10.1101/2025...
👇
April 18, 2025 at 9:36 AM
On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.
Exciting paper - lots of things to discover in the data and the approach!
Nature research paper: Multimodal cell maps as a foundation for structural and functional genomics
https://go.nature.com/3YpvALv
https://go.nature.com/3YpvALv
Multimodal cell maps as a foundation for structural and functional genomics - Nature
A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paediatric cancer genomes.
go.nature.com
April 17, 2025 at 1:52 PM
Exciting paper - lots of things to discover in the data and the approach!