Mark Dodding
@markdodding.bsky.social
Professor of Molecular Cell Biology at Bristol - microtubules, actin and motors
Pinned
Mark Dodding
@markdodding.bsky.social
· Apr 17
Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch
Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects ...
elifesciences.org
Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...
Reposted by Mark Dodding
Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6...
Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
The unhindered lateral mobility of a rhomboid intramembrane protease enables synapse remodelling
Synapses must maintain their stable molecular organisation while retaining the capacity to remodel in response to changing demands. In order to flexibly change synaptic strength, the abundance of tran...
www.biorxiv.org
September 17, 2026 at 9:10 AM
Here it is my 1st preprint about synapse and rhomboid intramembrane protease: www.biorxiv.org/content/10.6...
Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
Using imaging and biochemistry, together with @adamgrieve.bsky.social we identify RHBDL2 as a membrane-immersed regulator of synapses architecture. 1/2
Reposted by Mark Dodding
We are hiring a Research Associate to join our lab in Bristol School of Chemistry. The project will involve protein design and engineering to understand and control intracellular transport.
Please share and get in touch if you are interested!
jesscrosslab.org
tinyurl.com/2aesevsu
Please share and get in touch if you are interested!
jesscrosslab.org
tinyurl.com/2aesevsu
Jess Cross Lab
Engineering Biology lab at the University of Bristol
jesscrosslab.org
August 26, 2026 at 11:44 AM
We are hiring a Research Associate to join our lab in Bristol School of Chemistry. The project will involve protein design and engineering to understand and control intracellular transport.
Please share and get in touch if you are interested!
jesscrosslab.org
tinyurl.com/2aesevsu
Please share and get in touch if you are interested!
jesscrosslab.org
tinyurl.com/2aesevsu
We were pleased to contribute to this important study led by Michael Zech (Munich), in collaboration with Roberto Steiner (Padova/KCL), linking de novo mutations that disrupt kinesin-1 cargo recognition to the neurological movement disorder dystonia. www.thelancet.com/journals/ebi...
Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features
Our research supports the existence of a kinesinopathy linked to KLC1, featuring phenotypic
overlap with diseases related to mutational defects of key interactors of KLC1. The
full dystonia de-novo va...
www.thelancet.com
June 29, 2026 at 8:04 PM
We were pleased to contribute to this important study led by Michael Zech (Munich), in collaboration with Roberto Steiner (Padova/KCL), linking de novo mutations that disrupt kinesin-1 cargo recognition to the neurological movement disorder dystonia. www.thelancet.com/journals/ebi...
Reposted by Mark Dodding
So great to see badass dynein assembly man Girish Mali @dyneinassembly.bsky.social amongst the Lister Prize winners joining our small but amazing motors subgroup with @simonbullock11.bsky.social @markdodding.bsky.social Viki Allan @susanagodinho.bsky.social Looking forward to seeing all in September
We are more than delighted to welcome our new #ListerPrize2026 Fellows! These eight inspiring researchers are set to pursue ambitious biomedical science, thanks to our flexible funding. Bravo! 👏
Meet the new #ListerFellows (read thread) and repost ⤵️
lister-institute.org.uk/news/our-lis...
Meet the new #ListerFellows (read thread) and repost ⤵️
lister-institute.org.uk/news/our-lis...
June 24, 2026 at 9:28 AM
So great to see badass dynein assembly man Girish Mali @dyneinassembly.bsky.social amongst the Lister Prize winners joining our small but amazing motors subgroup with @simonbullock11.bsky.social @markdodding.bsky.social Viki Allan @susanagodinho.bsky.social Looking forward to seeing all in September
Reposted by Mark Dodding
🚨 New paper alert 🧬
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.
We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.
👉 tinyurl.com/4de8teyh
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.
We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.
👉 tinyurl.com/4de8teyh
April 17, 2026 at 6:17 PM
🚨 New paper alert 🧬
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.
We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.
👉 tinyurl.com/4de8teyh
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.
We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.
👉 tinyurl.com/4de8teyh
Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...
Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch
Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects ...
elifesciences.org
April 17, 2026 at 2:10 PM
Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...
New preprint on kinesin inhibition and activation - collaborative effort across Bristol Biochem and Chemistry with Woolfson and Schaffizel labs and JJ Phillips in Exeter 1/2 www.biorxiv.org/content/10.1...
Molecular mechanism for cargo-mediated initiation of kinesin-1 activation
Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts a...
www.biorxiv.org
April 10, 2025 at 1:02 PM
New preprint on kinesin inhibition and activation - collaborative effort across Bristol Biochem and Chemistry with Woolfson and Schaffizel labs and JJ Phillips in Exeter 1/2 www.biorxiv.org/content/10.1...
We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...
January 9, 2025 at 3:59 PM
We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...
Reposted by Mark Dodding
The position is either funded by a UoB scholarship or SWBio DTP - to be considered for both pools of funding apply separately for each of these. Secondary sup. is the brilliant @markdodding.bsky.social. 📧 E-mail [email protected] for informal enquiries & 📝apply here tinyurl.com/yvzeb2kw.
Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol on FindAPhD.com
PhD Project - Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol, listed on FindAPhD.com
tinyurl.com
November 27, 2024 at 12:15 PM
The position is either funded by a UoB scholarship or SWBio DTP - to be considered for both pools of funding apply separately for each of these. Secondary sup. is the brilliant @markdodding.bsky.social. 📧 E-mail [email protected] for informal enquiries & 📝apply here tinyurl.com/yvzeb2kw.
Reposted by Mark Dodding
Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
November 28, 2024 at 4:55 PM
Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...
We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at Bristol Biochemistry supported by SWBio_DTP with Berni Carroll (lysosome transport), @abidalilab.bsky.social (endocytosis) and Jessica Cross (protein design)
see swbio.ac.uk/biomolecular...
see swbio.ac.uk/biomolecular...
Biomolecular and Biophysical Studies – SWBiosciences Doctoral Training Partnership
swbio.ac.uk
November 13, 2024 at 5:47 PM
We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at Bristol Biochemistry supported by SWBio_DTP with Berni Carroll (lysosome transport), @abidalilab.bsky.social (endocytosis) and Jessica Cross (protein design)
see swbio.ac.uk/biomolecular...
see swbio.ac.uk/biomolecular...