Oded Mayseless
@mayseless.bsky.social
Postdoc in the @schierlab. Visiting scientist @RainerFriedri12. PhD @lab_oren @WeizmannScience. What is the molecular basis of good vs evil? #zebrafish #olfaction
Pinned
Oded Mayseless
@mayseless.bsky.social
· Jun 16
1/11
Excited to share my postdoc work from
@schierlab.bsky.social and Rainer Friedrich! 🐟👃
How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵
Excited to share my postdoc work from
@schierlab.bsky.social and Rainer Friedrich! 🐟👃
How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵
Reposted by Oded Mayseless
The first Danionella paper from the lab. Danionella cerebrum is transparent, so you can see all of the internal organs. But what sensory information are the organs sending to the brain? In our new preprint, Emily Bayer wanted to find out. 1/4
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
September 8, 2026 at 1:58 PM
The first Danionella paper from the lab. Danionella cerebrum is transparent, so you can see all of the internal organs. But what sensory information are the organs sending to the brain? In our new preprint, Emily Bayer wanted to find out. 1/4
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Oded Mayseless
Ultrastructural reconstruction of hundreds of neurons by volume EM revealed cell types and a precise glomerular organization in the zebrafish olfactory bulb. A heroic effort by Nila! Special thanks to Nila @michalwj.bsky.social and the whole team!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb
Neuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of odor-evoked activity. These computations are medi...
www.biorxiv.org
September 8, 2026 at 9:41 AM
Ultrastructural reconstruction of hundreds of neurons by volume EM revealed cell types and a precise glomerular organization in the zebrafish olfactory bulb. A heroic effort by Nila! Special thanks to Nila @michalwj.bsky.social and the whole team!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Oded Mayseless
Imaging of activity in the telencephalon of adult zebrafish moving through a virtual reality revealed amazingly precise, structured internal representations of spatial environments. And they get better over time! Great work by Kim! Thanks also to Sriram and Jan.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Dynamic cognitive representations in the dorsal pallium of adult zebrafish
Brains rely on internal models of the world to interpret sensory input and to simulate the future. In the mammalian hippocampal-entorhinal network, environments are represented by cognitive maps that ...
www.biorxiv.org
September 8, 2026 at 9:47 AM
Imaging of activity in the telencephalon of adult zebrafish moving through a virtual reality revealed amazingly precise, structured internal representations of spatial environments. And they get better over time! Great work by Kim! Thanks also to Sriram and Jan.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Oded Mayseless
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex
Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...
www.biorxiv.org
September 8, 2026 at 9:55 AM
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Oded Mayseless
Do you work with microscopy images and segment to quantify or track? Do you study cell biology? development? Gather round! Let me tell you about FOCUS-3D, a segmentation algorithm that is fast, accurate and can be used on any model. We used it here to study zebrafish development. 🧪 (thread)
FOCUS‑3D: Robust, generalizable volumetric cell segmentation for three‑dimensional fluorescence microscopy
Understanding how cells establish spatial organization within tissues is a fundamental question in life sciences. While modern three-dimensional fluorescence microscopy captures large-volume tissue ar...
www.biorxiv.org
August 29, 2026 at 5:47 AM
Do you work with microscopy images and segment to quantify or track? Do you study cell biology? development? Gather round! Let me tell you about FOCUS-3D, a segmentation algorithm that is fast, accurate and can be used on any model. We used it here to study zebrafish development. 🧪 (thread)
Reposted by Oded Mayseless
What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...
Wake-activated neuronal populations that regulate sleep drive - Nature
Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red...
www.nature.com
August 19, 2026 at 3:41 PM
What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...
Reposted by Oded Mayseless
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
Apply - Interfolio
apply.interfolio.com
August 6, 2026 at 3:02 AM
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Reposted by Oded Mayseless
🚨New preprint doi.org/10.64898/2026.06.07.730682. We show that zebrafish larvae exhibit complex, internally generated, spontaneous behavioral patterns in the absence of stimuli. These dynamics can be described by a simple Markov process with transition probabilities that change over time.
August 3, 2026 at 1:07 PM
🚨New preprint doi.org/10.64898/2026.06.07.730682. We show that zebrafish larvae exhibit complex, internally generated, spontaneous behavioral patterns in the absence of stimuli. These dynamics can be described by a simple Markov process with transition probabilities that change over time.
Reposted by Oded Mayseless
Yet another #zebrafish genome update:
We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:
We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:
genome.ucsc.edu
July 30, 2026 at 10:20 PM
Yet another #zebrafish genome update:
We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:
We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:
Reposted by Oded Mayseless
Finally out in @natneuro.nature.com!
A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work!
www.nature.com/articles/s41...
A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work!
www.nature.com/articles/s41...
Creating true and false memories from forgotten information in Drosophila - Nature Neuroscience
Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...
www.nature.com
July 31, 2026 at 7:41 AM
Finally out in @natneuro.nature.com!
A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work!
www.nature.com/articles/s41...
A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work!
www.nature.com/articles/s41...
Reposted by Oded Mayseless
🧠 A new paper from our lab is out!
In this study, we explore how dorsal raphe nucleus (DRN) circuits modulate forebrain activity and behavior. www.nature.com/articles/s41...
In this study, we explore how dorsal raphe nucleus (DRN) circuits modulate forebrain activity and behavior. www.nature.com/articles/s41...
Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors - Nature Communications
Functional heterogeneity of dorsal raphe nucleus is not fully understood. Here authors show topographically organized sensory and locomotor responses from the zebrafish dorsal raphe and its forebrain ...
www.nature.com
July 17, 2026 at 7:24 PM
🧠 A new paper from our lab is out!
In this study, we explore how dorsal raphe nucleus (DRN) circuits modulate forebrain activity and behavior. www.nature.com/articles/s41...
In this study, we explore how dorsal raphe nucleus (DRN) circuits modulate forebrain activity and behavior. www.nature.com/articles/s41...
Reposted by Oded Mayseless
We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv!
July 6, 2026 at 6:22 PM
We're excited to present a single-cell atlas of vertebrate cranial motor neuron development, the first story from my postdoctoral work in the Moens lab, up now on bioRxiv!
Reposted by Oded Mayseless
We have an open professor position at my institute, the Institute for Quantitative Biosciences, The University of Tokyo!
www.iqb.u-tokyo.ac.jp/recruiting/2...
www.iqb.u-tokyo.ac.jp/recruiting/2...
www.iqb.u-tokyo.ac.jp
July 6, 2026 at 11:03 AM
We have an open professor position at my institute, the Institute for Quantitative Biosciences, The University of Tokyo!
www.iqb.u-tokyo.ac.jp/recruiting/2...
www.iqb.u-tokyo.ac.jp/recruiting/2...
Reposted by Oded Mayseless
🚨 New Preprint! 🚨: A new method for quantifying #tissue #clearing and a next-get #lightsheet #Microscope - the #mesoSPIM ultra by Marko Pende, @jcregg.bsky.social, @murawalalab.bsky.social @mdibl.org & many more!
Preprint: www.biorxiv.org/content/10.6...
Github: github.com/mesoSPIM/mes...
Preprint: www.biorxiv.org/content/10.6...
Github: github.com/mesoSPIM/mes...
July 6, 2026 at 1:06 PM
🚨 New Preprint! 🚨: A new method for quantifying #tissue #clearing and a next-get #lightsheet #Microscope - the #mesoSPIM ultra by Marko Pende, @jcregg.bsky.social, @murawalalab.bsky.social @mdibl.org & many more!
Preprint: www.biorxiv.org/content/10.6...
Github: github.com/mesoSPIM/mes...
Preprint: www.biorxiv.org/content/10.6...
Github: github.com/mesoSPIM/mes...
Reposted by Oded Mayseless
We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!
Early visual experience elicits cellular and functional plasticity in the retina and alters behavior
The understanding of experience-dependent plasticity in the vertebrate retina is largely
incomplete. Reynolds et al. discovered that raising animals in differently patterned
visual environments change...
www.cell.com
July 5, 2026 at 9:11 PM
We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!
Reposted by Oded Mayseless
I am excited to announce the latest paper from our lab, published in Science !
In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
July 2, 2026 at 6:54 PM
I am excited to announce the latest paper from our lab, published in Science !
In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
Reposted by Oded Mayseless
Happy to share our new paper published in @currentbiology.bsky.social! Using in vivo imaging of genetically defined zebrafish retinal ganglion cells (RGCs), we show that while some Satb2+ RGCs maintain stable functional identities during development, others undergo functional changes.
July 1, 2026 at 3:38 PM
Happy to share our new paper published in @currentbiology.bsky.social! Using in vivo imaging of genetically defined zebrafish retinal ganglion cells (RGCs), we show that while some Satb2+ RGCs maintain stable functional identities during development, others undergo functional changes.
Reposted by Oded Mayseless
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26.
It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome.
apply.interfolio.com/187735
It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome.
apply.interfolio.com/187735
June 30, 2026 at 5:05 PM
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26.
It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome.
apply.interfolio.com/187735
It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome.
apply.interfolio.com/187735
Reposted by Oded Mayseless
1/ 🧬🔬
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
June 29, 2026 at 8:00 PM
1/ 🧬🔬
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇
www.kaggle.com/competitions...
@biohub.org
Reposted by Oded Mayseless
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Loss of the conserved splicing factor for neuronal microexons disrupts neuromodulatory signaling and drives hyperarousal.
www.science.org
June 28, 2026 at 4:37 PM
Very excited to finally share my PhD! 🎉
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Our paper, “Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish,” is now published in Science Advances.
Many thanks to all of my co-authors, and especially to @mirimiam.bsky.social!
📄 www.science.org/doi/10.1126/...
Reposted by Oded Mayseless
We're hiring! The Department of Life Sciences at Imperial College London is seeking a new Assistant Professor in ecology, evolution, or environmental science. It's a great department with great students at a great university. www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
June 25, 2026 at 8:58 AM
We're hiring! The Department of Life Sciences at Imperial College London is seeking a new Assistant Professor in ecology, evolution, or environmental science. It's a great department with great students at a great university. www.imperial.ac.uk/jobs/search-...
Reposted by Oded Mayseless
I’m very excited to share that our paper is now out in Neuron! 🎉
June 23, 2026 at 4:59 PM
I’m very excited to share that our paper is now out in Neuron! 🎉
Reposted by Oded Mayseless
New paper out: www.cell.com/iscience/ful... Congratulations to our former PhD student @maxcapelle.bsky.social whose work reveals that the switch in light preference across zebrafish development is driven by a reweighting of three parallel visual processing pathways.
Check out a short summary below!
Check out a short summary below!
June 22, 2026 at 12:30 PM
New paper out: www.cell.com/iscience/ful... Congratulations to our former PhD student @maxcapelle.bsky.social whose work reveals that the switch in light preference across zebrafish development is driven by a reweighting of three parallel visual processing pathways.
Check out a short summary below!
Check out a short summary below!
Reposted by Oded Mayseless
Might cerebellar disinhibition underlie Restless Legs Syndrome symptoms? Will Joo found that loss of the RLS-associated gene meis1b perturbs locomotion in zebrafish by disinhibiting cerebellar output.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
June 17, 2026 at 4:01 PM
Might cerebellar disinhibition underlie Restless Legs Syndrome symptoms? Will Joo found that loss of the RLS-associated gene meis1b perturbs locomotion in zebrafish by disinhibiting cerebellar output.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Oded Mayseless
Congratulations! This was long in the making and the resulting data is quite beautiful. Definitely worth a read!
1/11
Excited to share my postdoc work from
@schierlab.bsky.social and Rainer Friedrich! 🐟👃
How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵
Excited to share my postdoc work from
@schierlab.bsky.social and Rainer Friedrich! 🐟👃
How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵
June 17, 2026 at 8:29 AM
Congratulations! This was long in the making and the resulting data is quite beautiful. Definitely worth a read!