David Meyer
meyerdh.bsky.social
David Meyer
@meyerdh.bsky.social
Dr. rer. nat. | Bioinformatician 🧬 |
Exploring Aging & Longevity with Machine Learning 🔍 | Unraveling Life's Code | C.elegans | Consultant
Reposted by David Meyer
🏆 Congratulations to our CGA alumni members Aishwarya Acharya @aishacharya.bsky.social and David Meyer @meyerdh.bsky.social on receiving the Klaus Liebrecht Award 2026 from the University of Cologne for their outstanding doctoral theses! 🎉 We are proud to celebrate this well-deserved success! 👏🧬
June 8, 2026 at 9:11 AM
Reposted by David Meyer
🚨Thrilled to share this exciting new paper by our #FOR5762 project leader @bjornschumacher.bsky.social, published in #NatureAging!

The study uncovers neuron-specific aging patterns and points to potential neuroprotective interventions.

Congratulations! 🎉

www.nature.com/articles/s43...
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
www.nature.com
February 5, 2026 at 9:11 AM
Reposted by David Meyer
🚨Excited to share this new review in @febsj.bsky.social by our #FOR5762 project leader @thevilchezlab.bsky.social!

The article explores how organelle #proteostasis preserves cellular function, and how its decline contributes to #aging and disease.

febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n...
febs.onlinelibrary.wiley.com
February 5, 2026 at 9:32 AM
Reposted by David Meyer
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
www.nature.com
February 3, 2026 at 11:44 AM
Reposted by David Meyer
🚨Publication Alert🚨
New work from our #CRC1678 members @bjornschumacher.bsky.social and @meyerdh.bsky.social reveals why some neurons age faster. Using neuron‑specific aging clocks, they identified vulnerable neurons and highlight syringic acid and vanoxerine as promising neuroprotective hits.🧬
February 3, 2026 at 10:54 AM
Why do some neuron types degenerate early while others stay intact?

We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability.
🧪

www.nature.com/articles/s43...

#Neurodegeneration 🧵👇 (1/n)
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
www.nature.com
February 3, 2026 at 10:31 AM
Reposted by David Meyer
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports
Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com
December 28, 2025 at 8:19 PM
Reposted by David Meyer
Happy to share that this is now out in Microbial Ecology 🥳 Huge thanks to the whole team, especially @sultanova.bsky.social 🙌

link.springer.com/article/10.1...

@leibnizfli.bsky.social @uniofeastanglia.bsky.social
December 27, 2025 at 10:25 AM
Reposted by David Meyer
1/6 In a new preprint we ask a question:

Why do males and females so often age and die at different rates?

We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:

ecoevorxiv.org/repository/v...
Sex-specific mutation accumulation: A parsimonious explanation for sex differences in lifespan and ageing
ecoevorxiv.org
November 19, 2025 at 12:08 PM
Happy to share our recent publication, which grew out of a consulting job I did last year:
www.nature.com/articles/s41...
🧵
https://nature.com/articles/s4159…
December 19, 2025 at 6:27 PM
Reposted by David Meyer
New study by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt showing that C. elegans dauer stage decelerates aging and even reverses biological age upon exit, revealing natural gene patterns of rejuvenation. Congratulations! 🎉
#AgingResearch #Longevity
December 10, 2025 at 12:36 PM
Reposted by David Meyer
🎥 Meet the 2025 SIB Bioinformatics Awards laureates:
⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award
⭐ Michael Skinnider @skinnider.bsky.social Early Career Award
⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold
Watch their award ceremony talks👇& congrats to all!
Celebrating excellence: meet the 2025 SIB Bioinformatics Awards laureates
Two early career bioinformaticians have been recognized for their mathematical and AI models, along with a collaborative resource for single-cell data analyses. The three 2025 SIB Bioinformatics Award...
www.sib.swiss
October 28, 2025 at 8:29 AM
Reposted by David Meyer
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 17, 2025 at 2:06 PM
Reposted by David Meyer
🚨🚨Job! 🚨🚨Permanent (75% time) job! We are a pretty awesome research group & seek a manager who deals with everything: personnel tasks, organizing retreats, preparing code for teaching / data structures for research... Fluency in German & English essential. stellenboerse.uni-mainz.de#/jgu/job/51527
stellenboerse.uni-mainz.de
October 17, 2025 at 7:38 AM
Reposted by David Meyer
Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel
The PhD Paper Award jury gives honourable mentions to:

Can Chen for “Structure-Aware Protein Self-Supervised Learning” doi.org/10.1093/bioi...

Yifan Zhao for “Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data” doi.org/10.1038/s414...

#bc2basel
Structure-aware protein self-supervised learning
AbstractMotivation. Protein representation learning methods have shown great potential to many downstream tasks in biological applications. A few recent st
doi.org
October 5, 2025 at 10:14 AM
Reposted by David Meyer
A fantastic few days of ageing talks, great people, and excellent food!

Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
October 2, 2025 at 2:04 PM
Reposted by David Meyer
Ribonucleotide incorporation into mitochondrial DNA drives inflammation

www.nature.com/articles/s41...

Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
www.nature.com
September 24, 2025 at 4:31 PM
Reposted by David Meyer
This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!
September 22, 2025 at 11:22 AM
Reposted by David Meyer
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 20, 2025 at 4:31 AM
Reposted by David Meyer
We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.
September 18, 2025 at 2:44 PM
Reposted by David Meyer
👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳
September 18, 2025 at 12:22 PM
You can also read it here
rdcu.be/eG1N7
👇
September 18, 2025 at 10:30 AM
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 9:08 AM
Reposted by David Meyer
💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻
✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.

Thank you for your guidance and inspiration @bjornschumacher.bsky.social

#SIBAwards #bc2basel #Bioinformatics
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel
September 15, 2025 at 4:04 PM
✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.

Thank you for your guidance and inspiration @bjornschumacher.bsky.social

#SIBAwards #bc2basel #Bioinformatics
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel
September 11, 2025 at 8:17 AM