Bratislav Misic
@misicbata.bsky.social
Pinned
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
Reposted by Bratislav Misic
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health.
🧪#AcademicSky
plos.io/4eoIu3L
🧪#AcademicSky
plos.io/4eoIu3L
June 16, 2026 at 8:15 AM
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health.
🧪#AcademicSky
plos.io/4eoIu3L
🧪#AcademicSky
plos.io/4eoIu3L
Reposted by Bratislav Misic
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health.
🧪#AcademicSky
plos.io/4eoIu3L
🧪#AcademicSky
plos.io/4eoIu3L
June 16, 2026 at 12:29 PM
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health.
🧪#AcademicSky
plos.io/4eoIu3L
🧪#AcademicSky
plos.io/4eoIu3L
Reposted by Bratislav Misic
Our latest, led by @ivaili.bsky.social out now in Nature Mental Health using normative modelling to understand the heterogeneity of atypical FC in autism. Peep the thread...
Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health
www.nature.com/articles/s44...
With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel
www.nature.com/articles/s44...
With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel
Multiscale heterogeneity of atypical functional connectivity in autism - Nature Mental Health
Using normative modeling to measure the interindividual variability of atypical brain functional connectivity in autism, the authors identify heterogeneity at the level of specific connections alongsi...
www.nature.com
June 7, 2026 at 12:20 AM
Our latest, led by @ivaili.bsky.social out now in Nature Mental Health using normative modelling to understand the heterogeneity of atypical FC in autism. Peep the thread...
Reposted by Bratislav Misic
Do humans show sex differences in brain activation? If so, are these task-specific or general — and do they relate to sex differences in brain anatomy and behavior?
We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
May 28, 2026 at 1:58 AM
Do humans show sex differences in brain activation? If so, are these task-specific or general — and do they relate to sex differences in brain anatomy and behavior?
We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
Reposted by Bratislav Misic
Delighted that our paper about benchmarking gene expression 🧬 in macaque brain 🐒🧠(www.science.org/doi/10.1126/...) was selected for this year's Brain Star Award of the Canadian Neuroscience Association 🇨🇦 - what an honour to be named among such talented scientists!
May 20, 2026 at 8:58 AM
Delighted that our paper about benchmarking gene expression 🧬 in macaque brain 🐒🧠(www.science.org/doi/10.1126/...) was selected for this year's Brain Star Award of the Canadian Neuroscience Association 🇨🇦 - what an honour to be named among such talented scientists!
Reposted by Bratislav Misic
My most recent and biggest work so far is finally out as a preprint! 🧠🧵
*Linking human brain functional connectivity to underlying neurotransmission*
doi.org/10.64898/202...
1/n
TL;DR below ↓
#neuroskyence #neuroimaging #MedSky #PsySciSky
*Linking human brain functional connectivity to underlying neurotransmission*
doi.org/10.64898/202...
1/n
TL;DR below ↓
#neuroskyence #neuroimaging #MedSky #PsySciSky
May 7, 2026 at 11:01 AM
My most recent and biggest work so far is finally out as a preprint! 🧠🧵
*Linking human brain functional connectivity to underlying neurotransmission*
doi.org/10.64898/202...
1/n
TL;DR below ↓
#neuroskyence #neuroimaging #MedSky #PsySciSky
*Linking human brain functional connectivity to underlying neurotransmission*
doi.org/10.64898/202...
1/n
TL;DR below ↓
#neuroskyence #neuroimaging #MedSky #PsySciSky
Reposted by Bratislav Misic
Benchmarking spatial interpolation methods for brain maps https://www.biorxiv.org/content/10.64898/2026.04.27.721143v1
April 30, 2026 at 10:16 PM
Benchmarking spatial interpolation methods for brain maps https://www.biorxiv.org/content/10.64898/2026.04.27.721143v1
Reposted by Bratislav Misic
Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
April 17, 2026 at 3:35 PM
Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Bratislav Misic
We develop a new TMS targeting algorithm and test it in an open label trial in a treatment-resistant depression population with high comorbidities. Preprints by @rubykong92.bsky.social Phern-Chern Tor
1. doi.org/10.1101/2025...
2. doi.org/10.64898/202...
Our new approach ...
1. doi.org/10.1101/2025...
2. doi.org/10.64898/202...
Our new approach ...
April 9, 2026 at 3:05 AM
We develop a new TMS targeting algorithm and test it in an open label trial in a treatment-resistant depression population with high comorbidities. Preprints by @rubykong92.bsky.social Phern-Chern Tor
1. doi.org/10.1101/2025...
2. doi.org/10.64898/202...
Our new approach ...
1. doi.org/10.1101/2025...
2. doi.org/10.64898/202...
Our new approach ...
Reposted by Bratislav Misic
April 8, 2026 at 1:11 AM
Reposted by Bratislav Misic
Structure-function coupling in the human brainstem https://www.biorxiv.org/content/10.64898/2026.04.05.716603v1
April 7, 2026 at 11:15 AM
Structure-function coupling in the human brainstem https://www.biorxiv.org/content/10.64898/2026.04.05.716603v1
Reposted by Bratislav Misic
Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much!
doi.org/10.64898/202...
arxiv.org/html/2603.07...
Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!
doi.org/10.64898/202...
arxiv.org/html/2603.07...
Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!
March 27, 2026 at 1:31 AM
Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much!
doi.org/10.64898/202...
arxiv.org/html/2603.07...
Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!
doi.org/10.64898/202...
arxiv.org/html/2603.07...
Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!
Reposted by Bratislav Misic
Our lab has an opening for a full-time research assistant, to work on human neuroimaging techniques and the neuroscience of sleep! To apply: massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Clinical Research Coordinator
Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to adva...
massgeneralbrigham.wd1.myworkdayjobs.com
March 20, 2026 at 6:53 PM
Our lab has an opening for a full-time research assistant, to work on human neuroimaging techniques and the neuroscience of sleep! To apply: massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Reposted by Bratislav Misic
Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function
#neuroskyence #compneuro #neuroscience
#neuroskyence #compneuro #neuroscience
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415...
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
March 18, 2026 at 3:02 PM
Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function
#neuroskyence #compneuro #neuroscience
#neuroskyence #compneuro #neuroscience
Reposted by Bratislav Misic
📢 New preprint from the lab🧠
▶️doi.org/10.64898/2026.03.12.710517
What does fMRI connectivity actually reflect at the neural level?
The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more!
👇🧵
▶️doi.org/10.64898/2026.03.12.710517
What does fMRI connectivity actually reflect at the neural level?
The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more!
👇🧵
March 18, 2026 at 12:15 PM
📢 New preprint from the lab🧠
▶️doi.org/10.64898/2026.03.12.710517
What does fMRI connectivity actually reflect at the neural level?
The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more!
👇🧵
▶️doi.org/10.64898/2026.03.12.710517
What does fMRI connectivity actually reflect at the neural level?
The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more!
👇🧵
Reposted by Bratislav Misic
Our work on gene therapy for creatine transporter deficiency is now online in #Brain
➡️https://doi.org/10.1093/brain/awaf275
In this study we (i) characterize network-level and behavioral alterations in a common form of monogenic #autism and (ii) test whether gene therapy can rescue these deficits
🧵
➡️https://doi.org/10.1093/brain/awaf275
In this study we (i) characterize network-level and behavioral alterations in a common form of monogenic #autism and (ii) test whether gene therapy can rescue these deficits
🧵
March 17, 2026 at 2:31 PM
Reposted by Bratislav Misic
The program is coming together well for the Brain Connectivity Workshop www.bcw2026.org/program. This will be our 25th year! Consider coming just before the #OHBM annual meeting. #Neuroscience
Program — BCW 2026: June 10-12
www.bcw2026.org
March 16, 2026 at 3:05 PM
The program is coming together well for the Brain Connectivity Workshop www.bcw2026.org/program. This will be our 25th year! Consider coming just before the #OHBM annual meeting. #Neuroscience
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415...
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
March 17, 2026 at 1:25 PM
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415...
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Reposted by Bratislav Misic
Just out in @natneuro.nature.com! 🧠
“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...
Is large-scale brain communication purely cooperative — or is competition a core organizing principle?
We built 🧠 models to find out: read on🧵👇
“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...
Is large-scale brain communication purely cooperative — or is competition a core organizing principle?
We built 🧠 models to find out: read on🧵👇
Competitive interactions shape mammalian brain network dynamics and computation - Nature Neuroscience
Brain network architecture may balance cooperation and competition across circuits. Here the authors use computational whole-brain modeling across three species to show that models with competition ar...
www.nature.com
March 13, 2026 at 12:23 PM
Just out in @natneuro.nature.com! 🧠
“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...
Is large-scale brain communication purely cooperative — or is competition a core organizing principle?
We built 🧠 models to find out: read on🧵👇
“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...
Is large-scale brain communication purely cooperative — or is competition a core organizing principle?
We built 🧠 models to find out: read on🧵👇
Reposted by Bratislav Misic
🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI).
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊
March 12, 2026 at 12:07 PM
🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI).
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour...
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
March 11, 2026 at 7:56 PM
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour...
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
March 11, 2026 at 6:57 PM
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
Reposted by Bratislav Misic
🚨Another new one from the lab!
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
We simulate sensory cascades in a bona fide biological neural network.
With Caio Seguin, Maria Grazia Puxeddu, and @misicbata.bsky.social!
journals.plos.org/complexsyste...
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
We simulate sensory cascades in a bona fide biological neural network.
With Caio Seguin, Maria Grazia Puxeddu, and @misicbata.bsky.social!
journals.plos.org/complexsyste...
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
Author summary To understand how the brain processes and merges information from our senses, we need more than just a “wiring map” of its connections; we need to see how signals actually travel throug...
journals.plos.org
March 5, 2026 at 7:43 PM
🚨Another new one from the lab!
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
We simulate sensory cascades in a bona fide biological neural network.
With Caio Seguin, Maria Grazia Puxeddu, and @misicbata.bsky.social!
journals.plos.org/complexsyste...
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
We simulate sensory cascades in a bona fide biological neural network.
With Caio Seguin, Maria Grazia Puxeddu, and @misicbata.bsky.social!
journals.plos.org/complexsyste...
Reposted by Bratislav Misic
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
March 5, 2026 at 1:40 PM
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
Reposted by Bratislav Misic
🚨 New Paper: Controlling the Human Connectome with Spatially Diffuse Input Signals
Now in press at Communications Biology!
www.nature.com/articles/s42...
Now in press at Communications Biology!
www.nature.com/articles/s42...
February 28, 2026 at 11:55 PM
🚨 New Paper: Controlling the Human Connectome with Spatially Diffuse Input Signals
Now in press at Communications Biology!
www.nature.com/articles/s42...
Now in press at Communications Biology!
www.nature.com/articles/s42...