Ciaran Murphy-Royal
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murphyroyallab.org
Ciaran Murphy-Royal
@murphyroyallab.org
Neuroscientist | Associate Professor @ University of Montreal Hospital Research Centre

Astrocytes as contextual regulators of brain states & behaviour

PI @ murphyroyallab.org
Pinned
Incredibly proud of this paper led by @ossamaghenissa.bsky.social and @mathiasgua.bsky.social titled Basolateral 'Amygdala Astrocytes Encode Anxiety States'.
www.cell.com/neuron/fullt...
🧵 below
Basolateral amygdala astrocytes encode anxiety states
Ghenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...
www.cell.com
Reposted by Ciaran Murphy-Royal
I'm thrilled to share our recent publication “Overlapping representations in the ventral hippocampus support rapid fear memory retrieval”

www.nature.com/articles/s41...

We asked, what is the moment-to-moment link between HPC spatial representations, memory retrieval, and fear behaviour?
Overlapping representations in the ventral hippocampus support rapid fear memory retrieval - Nature Neuroscience
Fear learning increases the similarity of threatening and neutral context representations in ventral CA1, which may enable faster reinstatement of threat memories, compared to dorsal CA1.
www.nature.com
September 16, 2026 at 4:20 PM
Reposted by Ciaran Murphy-Royal
"MIT wants to rebuild education around the things AI can't replace. That means oral exams, semester portfolios, in-person project work, and a required social component in every subject. The report even floats the idea of rethinking grades entirely..."

This is the way forward
@tcddublin.bsky.social
MIT has put out an "AI and Education" report summarizing what they've found at their own institution. Seems thoughtful. aiandeducation.mit.edu/report/
September 13, 2026 at 9:54 AM
Reposted by Ciaran Murphy-Royal
🚨🚨 New preprint from us at the LGC lab. Super excited to share this story since starting my post-doc! 🤩 If you are interested in astrocytes, mitochondria, and anxiety behaviour be sure to check it out!! Thanks to all the collaborators :)
Low testosterone promotes anxiety through astrocytic mitochondrial remodelling at the nucleus accumbens blood-brain barrier https://www.biorxiv.org/content/10.64898/2026.09.03.749088v1
September 9, 2026 at 8:52 AM
Reposted by Ciaran Murphy-Royal
Spotlight on Emerging Talent
Congrats to Lewis Depaauw-Holt (Université de Montréal), a #GLIA2025 stipend winner!
His research shows how #astrocytes regulate stress responses in a sex-specific manner by shaping orexin neuron activity and behaviour.

#NetworkGlia #Astrocytes
August 28, 2026 at 11:57 AM
Reposted by Ciaran Murphy-Royal
Join us in Lausanne on 7 Oct for a 1-day Symposium

We will bridge the field of stress & resilience with cognitive ageing and brain rejuvenation

Outstanding keynotes, talks, posters & discussion

Places first come first served

Poster abstracts + registration by 7 Sept: www.epfl.ch/research/dom...
August 22, 2026 at 3:14 PM
Reposted by Ciaran Murphy-Royal
🚨🚨 just over 2-months until the Brain Resilience Symposium here at EPFL! Super excited to be sharing some of the work we've been doing here in the LGC lab 💪
August 11, 2026 at 2:14 PM
Excellent reporting on astrocyte-engram work from @junnagai.bsky.social, @m-r-williamson.bsky.social and others.

This article captures just how much of a frontier research area astrocyte engrams represent, and I’m excited to see how the field unfolds.

www.thetransmitter.org/memory/are-p...
Are parts of the memory trace found in the ‘astroengram?’
Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.
www.thetransmitter.org
August 10, 2026 at 1:20 PM
Reposted by Ciaran Murphy-Royal
So proud to have “Early-life stress alters H3K4me1 in VTA to prime stress sensitivity” out now in Neuron! This work spanned Many years and Many people contributed. Huge thanks to @hyejaykim.bsky.social, @ja-balouek.bsky.social, Luke Geiger, and Meaghan Creed
www.cell.com/neuron/fullt...
Early-life stress alters H3K4me1 in VTA to prime stress sensitivity
Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...
www.cell.com
August 7, 2026 at 3:16 PM
Super fun symposium at Neuro2026 Kobe discussing ‘Adaptive glia: from homeostasis to allostasis under stress’ with Micheal Wheeler, @cate-cholamine.bsky.social , Josselyn Soto, @junnagai.bsky.social and myself!
Such a fascinating and innovative field!
July 31, 2026 at 8:31 AM
After a busy week in Nagoya at the Neuroendocrinology meeting, both @mathiasgua.bsky.social & @ossamaghenissa.bsky.social made the lab proud, presenting at the Japanese Neuroscience society meeting (Neuro2026) in Kobe
July 31, 2026 at 12:17 AM
Reposted by Ciaran Murphy-Royal
Pain avoidance can protect us, but in chronic pain, it can become part of the problem.

Our new collaborative study reveals altered pain-avoidance learning in CRPS, linked to anxiety and reduced prefrontal alpha activity.

doi.org/10.1002/ejp....

#CRPS #PainResearch @crchum.bsky.social
July 27, 2026 at 10:05 PM
Excellent overview of our recent publication in Neuron by Xinzhu Yu and Bal Khakh ! www.cell.com/neuron/abstr...
Amygdala astrocytes encode anxiety states
In this issue of Neuron, Ghenissa and colleagues1 show that intracellular Ca2+ signaling within populations of astrocytes in the basolateral amygdala of mice encodes anxiety states that are regulated ...
www.cell.com
July 15, 2026 at 3:48 PM
Reposted by Ciaran Murphy-Royal
It was lovely to see Thomas Papouin at #FENS2026. Thomas presented a really exciting story and it was lovely to catch up! He's such a star ✨

@papouinlab.bsky.social
July 10, 2026 at 11:17 AM
Reposted by Ciaran Murphy-Royal
The social event of the European Glial Cells Network was a fantastic opportunity to meet, connect, and exchange ideas with fellow glial cell researchers over delicious tapas 🥘, refreshing beers 🍻, and authentic sangria 🍷. Great conversations, new connections, and a wonderful atmosphere! 🧠✨ #FENSGlia
July 9, 2026 at 5:57 AM
Reposted by Ciaran Murphy-Royal
Excellent symposium on glial cell sex differences at #FENS2026! A great reminder that sex is a critical biological variable in neuroscience.
Thanks to Kerstin Lenk, Julia Schulze-Hentrich, @murphyroyallab.org and @dibenedetto-lab.bsky.social for the inspiring talks!
#FENSGlia #Astrocytes
July 8, 2026 at 9:37 AM
Reposted by Ciaran Murphy-Royal
FENSGlia – Building the International Glia Community
We end today's series by bringing the community together!
Join us for the #FENSGlia Social Evening on Wed, 8 July, 20:00 at Plaça d'Osca, Barcelona. Wear your GLIA sticker from Booth 158 to spot fellow gliologists. See you there!

#FENS2026
July 2, 2026 at 2:30 PM
Delighted to see @lewisholt.bsky.social receive this prestigious recognition for all his hard work in the lab! 💪
Research led by Lewis Depaauw-Holt shows brain cells called astrocytes play key roles in sex-specific changes in brain and behaviour caused by early-life stress - can-acn.org/brain-star-a...
June 30, 2026 at 3:09 PM
Reposted by Ciaran Murphy-Royal
I'm looking to hire a research technician/lab manager. This role is ideal for someone looking to gain experience and independence after undergraduate research on their way to graduate school.

Please encourage anyone interested to apply: hr.myu.umn.edu/jobs/ext/374... (job code 374183)
Careers
The Fraser Lab at the University of Minnesota (https://fraserlab.psych.umn.edu/) is recruiting a full-time research technician to support the lab. As a part of the Department of Psychology we are involved in the greater neuroscience research community at the University of Minnesota which provides excellent access to training and professional development. The Fraser Lab is interested in the neurobiological basis of motivated behavior and investigates how defined brain circuits contribute to behavioral regulation. We make use of modern neuroscience approaches to record and manipulate neural activity in real-time as rodents perform complex behavioral tasks to relate precise aspects of neural activity to well-defined psychological processes. To do so, we regularly use optogenetics, chemogenetics, calcium imaging, biosensors, pharmacology, and immunohistochemistry. Our ultimate goal is to decipher the neural mechanisms regulating behavior and to characterize how these are altered in psychiatric illness, such as addiction, or by differences in lived experience, such as after early life adversity, to potentially identify novel therapeutics. We seek a team member who can play a lead role in lab operations, collaborate closely with the PI, and engage in team-building and growth.Duties:Laboratory logistics, maintenance and operations (30%):
hr.myu.umn.edu
June 18, 2026 at 1:22 AM
Great initiative from Marie-Josette de Medeiros (PhD student) who invited a group of local high-school students to spend a day seeing what being a scientist is all about !

Most have never visited a lab, so it’ll be interesting to hear their opinions by the end of the day.
May 28, 2026 at 3:47 PM
Lab views on point this morning!
May 28, 2026 at 1:00 PM
Reposted by Ciaran Murphy-Royal
🧠 New preprint from our lab!
#Hippocampal #astrocytes actively contribute to:
👉 the encoding of #context-specific #aversive stimuli
👉 predict #recall of #fear #behavior.

@icvs-uminho.bsky.social
@caixaresearch.bsky.social
#PTglia
May 25, 2026 at 11:38 AM
Great turnout for the career networking session this afternoon at @canacn.bsky.social !
Huge thanks to all the participants for making it great!
May 21, 2026 at 10:11 PM
Reposted by Ciaran Murphy-Royal
Thrilled to share that I’ll be starting my lab at the SickKids Research Institute and University of Toronto in August!

williamsonlab.ca

Recruiting at all levels. Get in touch if you’re interested in astrocyte biology of cognition and disease!
Williamson Lab
The Williamson Lab studies astrocyte biology across development, cognition, and disease.
williamsonlab.ca
May 19, 2026 at 1:16 PM