Paz Duran
@pazduran.bsky.social
Postdoctoral Research Associate at NYU Pain Research Center studying mechanisms underlying chronic pain and itch.
Reposted by Paz Duran
Great to have Dr. Ishmail Abdus-Saboor visit the PRC today! It was exciting to hear about his work on the skin-brain axis and to spend the day talking science. Thank you @ishmailsaboor.bsky.social!
September 16, 2026 at 7:21 PM
Great to have Dr. Ishmail Abdus-Saboor visit the PRC today! It was exciting to hear about his work on the skin-brain axis and to spend the day talking science. Thank you @ishmailsaboor.bsky.social!
Reposted by Paz Duran
NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...
Frontiers | The contribution of endocytic mediators to itch transmission
IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...
www.frontiersin.org
July 14, 2026 at 5:14 PM
NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...
Reposted by Paz Duran
NEW PRC PAPER 🚨: The Jensen lab discovered that the human itch receptor MrGPRX1 traffics to the endosomal network, where it continues to signal and drive TRPV1 sensitization. Congratulations to first author @pazduran.bsky.social and the whole team!
www.frontiersin.org/journals/mol...
www.frontiersin.org/journals/mol...
Frontiers | Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch
G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes...
www.frontiersin.org
July 9, 2026 at 6:09 PM
NEW PRC PAPER 🚨: The Jensen lab discovered that the human itch receptor MrGPRX1 traffics to the endosomal network, where it continues to signal and drive TRPV1 sensitization. Congratulations to first author @pazduran.bsky.social and the whole team!
www.frontiersin.org/journals/mol...
www.frontiersin.org/journals/mol...
Reposted by Paz Duran
NEW PRC PAPER 🚨 from Nestor Jimenez-Vargas and the Bunnett Lab reveals how elevated proteases and histamine drive IBS visceral pain, showing that a prolonged intracellular PAR2 receptor signaling loop keeps the H1 receptor active to continuously amplify and maintain pain. gut.bmj.com/content/earl...
June 17, 2026 at 6:43 PM
NEW PRC PAPER 🚨 from Nestor Jimenez-Vargas and the Bunnett Lab reveals how elevated proteases and histamine drive IBS visceral pain, showing that a prolonged intracellular PAR2 receptor signaling loop keeps the H1 receptor active to continuously amplify and maintain pain. gut.bmj.com/content/earl...
Reposted by Paz Duran
Amazing work from @tonelloraquel.bsky.social!
📣Excited to share our new preprint!
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models.
www.biorxiv.org/content/10.6...
Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief
Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...
www.biorxiv.org
June 23, 2026 at 1:48 PM
Amazing work from @tonelloraquel.bsky.social!
Reposted by Paz Duran
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
May 28, 2026 at 7:29 PM
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Reposted by Paz Duran
In a new study, researchers describe a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more on #DNADay: https://scim.ag/3OEc2RV
Learn more on #DNADay: https://scim.ag/3OEc2RV
April 25, 2026 at 2:12 PM
In a new study, researchers describe a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more on #DNADay: https://scim.ag/3OEc2RV
Learn more on #DNADay: https://scim.ag/3OEc2RV
Reposted by Paz Duran
Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social
March 27, 2026 at 3:47 PM
Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social
Reposted by Paz Duran
Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social
March 24, 2026 at 12:54 PM
Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social
Reposted by Paz Duran
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
March 24, 2026 at 1:58 AM
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Reposted by Paz Duran
NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social
March 13, 2026 at 1:45 PM
NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social
Reposted by Paz Duran
In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH
December 19, 2025 at 2:00 PM
In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH
Reposted by Paz Duran
Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social
November 19, 2025 at 4:26 PM
Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social
Reposted by Paz Duran
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
buff.ly
June 11, 2025 at 5:25 PM
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
Reposted by Paz Duran
Check out articles like “Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain” by Martin et al. in #PAIN bit.ly/3YxTyUV
May 12, 2025 at 6:00 PM
Check out articles like “Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain” by Martin et al. in #PAIN bit.ly/3YxTyUV
Reposted by Paz Duran
Bavencoffe et al. find that hyperexcitability in nociceptor somata isolated from ganglia innervating painful and nonpainful regions suggests new functions for widespread, ongoing nociceptor activity. Learn more in #PAIN bit.ly/3G4Y5rB
May 13, 2025 at 12:00 PM
Bavencoffe et al. find that hyperexcitability in nociceptor somata isolated from ganglia innervating painful and nonpainful regions suggests new functions for widespread, ongoing nociceptor activity. Learn more in #PAIN bit.ly/3G4Y5rB
Reposted by Paz Duran
Check out articles like “Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats” by O’Brien et al. in #PAIN bit.ly/3S2xpe3
May 19, 2025 at 6:00 PM
Check out articles like “Visual exposure to green light therapy reduces knee joint pain and alters the lipidome in osteoarthritic rats” by O’Brien et al. in #PAIN bit.ly/3S2xpe3
Reposted by Paz Duran
PRC Highlight: Congrats to @pazduran.bsky.social for "Best Poster Presentation Finalist in Basic Science" Titled "Compartmentalized Signaling Of Mas-related G-protein Coupled Receptor X1 (MrGPRX1) And Transient Receptor Potential Vanilloid (TRPV) Channels In Pain And Itch Pathways"👏 #USASP_2025
May 5, 2025 at 7:10 PM
PRC Highlight: Congrats to @pazduran.bsky.social for "Best Poster Presentation Finalist in Basic Science" Titled "Compartmentalized Signaling Of Mas-related G-protein Coupled Receptor X1 (MrGPRX1) And Transient Receptor Potential Vanilloid (TRPV) Channels In Pain And Itch Pathways"👏 #USASP_2025
Reposted by Paz Duran
Amazing talk by @tedpricethepainguy.bsky.social on progress in our understanding of pain mechanisms using human DRG and spinal cord. Really cool data on spinal projection neurons in human spinal cord. This is quite amazing!
May 2, 2025 at 5:43 PM
Amazing talk by @tedpricethepainguy.bsky.social on progress in our understanding of pain mechanisms using human DRG and spinal cord. Really cool data on spinal projection neurons in human spinal cord. This is quite amazing!
Reposted by Paz Duran
Congrats to all the poster award winners at #usasp2025! Very proud of my friend Paz Duran who won an award for her amazing work!
May 2, 2025 at 2:57 PM
Congrats to all the poster award winners at #usasp2025! Very proud of my friend Paz Duran who won an award for her amazing work!
Reposted by Paz Duran
Amazing times with @nyupainresearch.bsky.social at the @usasp.bsky.social meeting. Congratulations to all our post docs including @pazduran.bsky.social @sarahanajjar.bsky.social for their amazing presentations! @nyupainresearch.bsky.social @newyorkuniversity.bsky.social
May 2, 2025 at 1:16 AM
Amazing times with @nyupainresearch.bsky.social at the @usasp.bsky.social meeting. Congratulations to all our post docs including @pazduran.bsky.social @sarahanajjar.bsky.social for their amazing presentations! @nyupainresearch.bsky.social @newyorkuniversity.bsky.social
Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week!
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
April 30, 2025 at 2:44 PM
Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week!
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
#USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels
Reposted by Paz Duran
HOWZAT!! Amazing paper 🤩
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/...
Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/...
Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain
N-type calcium channel (CaV2.2) protein contributes to neuronal excitability and overactivation in sympathetic ganglion (SG) following myocardial infarction (MI), thereby easily triggering cardiac rem...
pubs.acs.org
April 8, 2025 at 7:02 PM
HOWZAT!! Amazing paper 🤩
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/...
Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain | ACS Nano pubs.acs.org/doi/10.1021/...
Thrilled they used our peptide CBD3 (PMID:21642979), from CRMP2, & independently replicated our data 🎉
CaV1.3 channels are vital for dopamine neuron function. We found that mutant LRRK2 (G2019S) enhances their activity via CaVβ3 phosphorylation, a potential key factor in Parkinson's disease. #neuroscience #ionchannels #ParkinsonsDisease #LRRK2 #CaV1.3 www.mdpi.com/1422-0067/26...
www.mdpi.com
March 31, 2025 at 11:25 AM
CaV1.3 channels are vital for dopamine neuron function. We found that mutant LRRK2 (G2019S) enhances their activity via CaVβ3 phosphorylation, a potential key factor in Parkinson's disease. #neuroscience #ionchannels #ParkinsonsDisease #LRRK2 #CaV1.3 www.mdpi.com/1422-0067/26...