RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
Pinned
RyanLab_TCD
@ryanlab.bsky.social
· Nov 20
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by RyanLab_TCD
#WeekendRead! #RememberMe!
@khannakm.bsky.social @payalyokota.bsky.social &co show @nature.com that previous parasite lung infections drive chormatin programs in nerve-associated macrophages fostering type 2 & repair programs, protecting against subsequent lethal influenza infections!
@khannakm.bsky.social @payalyokota.bsky.social &co show @nature.com that previous parasite lung infections drive chormatin programs in nerve-associated macrophages fostering type 2 & repair programs, protecting against subsequent lethal influenza infections!
Type 2 immune history trains lung macrophages for viral disease tolerance - Nature
Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...
www.nature.com
October 3, 2026 at 3:54 PM
#WeekendRead! #RememberMe!
@khannakm.bsky.social @payalyokota.bsky.social &co show @nature.com that previous parasite lung infections drive chormatin programs in nerve-associated macrophages fostering type 2 & repair programs, protecting against subsequent lethal influenza infections!
@khannakm.bsky.social @payalyokota.bsky.social &co show @nature.com that previous parasite lung infections drive chormatin programs in nerve-associated macrophages fostering type 2 & repair programs, protecting against subsequent lethal influenza infections!
📢Last weeks #immunometabolism discoveries mitoworld.org @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting highlight:
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press
biomed.news/bims-imicid/...
Interesting highlight:
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press
September 23, 2026 at 8:46 AM
📢Last weeks #immunometabolism discoveries mitoworld.org @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting highlight:
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press
biomed.news/bims-imicid/...
Interesting highlight:
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press
📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease
biomed.news/bims-imicid/...
Interesting finding:
Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease
September 14, 2026 at 8:14 PM
📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease
biomed.news/bims-imicid/...
Interesting finding:
Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease
🚨 We’re hiring a postdoctoral research associate!
This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunometabolism, or primary mitochondrial disease.
For more information email: [email protected] and include your CV and cover letter
This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunometabolism, or primary mitochondrial disease.
For more information email: [email protected] and include your CV and cover letter
September 7, 2026 at 1:02 PM
🚨 We’re hiring a postdoctoral research associate!
This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunometabolism, or primary mitochondrial disease.
For more information email: [email protected] and include your CV and cover letter
This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunometabolism, or primary mitochondrial disease.
For more information email: [email protected] and include your CV and cover letter
📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4 #mitochondria
biomed.news/bims-imicid/...
Interesting finding:
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4 #mitochondria
September 7, 2026 at 12:39 PM
📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4 #mitochondria
biomed.news/bims-imicid/...
Interesting finding:
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4 #mitochondria
📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate
biomed.news/bims-imicid/...
Interesting finding:
The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate
July 27, 2026 at 1:22 PM
📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate
biomed.news/bims-imicid/...
Interesting finding:
The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate
Reposted by RyanLab_TCD
Susumu Tonegawa, sole recipient of the 1987 Nobel Prize in Medicine for the discovery of VDJ rearrangements.
news.mit.edu/2026/mit-pro...
news.mit.edu/2026/mit-pro...
July 15, 2026 at 9:55 PM
Susumu Tonegawa, sole recipient of the 1987 Nobel Prize in Medicine for the discovery of VDJ rearrangements.
news.mit.edu/2026/mit-pro...
news.mit.edu/2026/mit-pro...
To support My Mito Mission, Stephen Burr and I are taking on an 127 km ultramarathon across the Wicklow mountains on the 24th of July to raise funds and awareness for mitochondrial disease research.
www.justgiving.com/page/dylan-s...
www.justgiving.com/page/dylan-s...
Dylan and Stephen's fundraiser for My Mito Mission
Help Dylan Ryan raise money to support My Mito Mission
www.justgiving.com
June 30, 2026 at 4:47 PM
To support My Mito Mission, Stephen Burr and I are taking on an 127 km ultramarathon across the Wicklow mountains on the 24th of July to raise funds and awareness for mitochondrial disease research.
www.justgiving.com/page/dylan-s...
www.justgiving.com/page/dylan-s...
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
biomed.news/bims-imicid/...
Interesting finding:
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
June 29, 2026 at 11:46 AM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
biomed.news/bims-imicid/...
Interesting finding:
Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Comparative Interactome Profiling of Itaconate and α-KG by the PELSA
II) Plasmacytoid DCs Exhibit High Transferrin Receptor Expression Without Iron Accumulation
biomed.news/bims-imicid/...
Interesting findings:
I) Comparative Interactome Profiling of Itaconate and α-KG by the PELSA
II) Plasmacytoid DCs Exhibit High Transferrin Receptor Expression Without Iron Accumulation
June 25, 2026 at 1:55 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting findings:
I) Comparative Interactome Profiling of Itaconate and α-KG by the PELSA
II) Plasmacytoid DCs Exhibit High Transferrin Receptor Expression Without Iron Accumulation
biomed.news/bims-imicid/...
Interesting findings:
I) Comparative Interactome Profiling of Itaconate and α-KG by the PELSA
II) Plasmacytoid DCs Exhibit High Transferrin Receptor Expression Without Iron Accumulation
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation
biomed.news/bims-imicid/...
Interesting paper:
Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation
June 15, 2026 at 12:29 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation
biomed.news/bims-imicid/...
Interesting paper:
Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation
📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
Mitochondrial OXPHOS restricts SARS-CoV-2 replication
#mitochondria
biomed.news/bims-imicid/...
Interesting finding:
Mitochondrial OXPHOS restricts SARS-CoV-2 replication
#mitochondria
June 9, 2026 at 9:19 AM
📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
Interesting finding:
Mitochondrial OXPHOS restricts SARS-CoV-2 replication
#mitochondria
biomed.news/bims-imicid/...
Interesting finding:
Mitochondrial OXPHOS restricts SARS-CoV-2 replication
#mitochondria
📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT 2026 in sunny Angers Saint-Laud ☀️ @biomednews.bsky.social ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Interesting finding:
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Interesting finding:
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation
June 1, 2026 at 8:54 PM
📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT 2026 in sunny Angers Saint-Laud ☀️ @biomednews.bsky.social ⬇️ ⬇️ ⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Interesting finding:
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Interesting finding:
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation
Reposted by RyanLab_TCD
Does mitochondrial respiration in DCs just “fuel” activation?
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
May 25, 2026 at 9:11 PM
Does mitochondrial respiration in DCs just “fuel” activation?
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
Reposted by RyanLab_TCD
New selection of papers on #Mitochondria in #Health & #Disease! 📚
biomed.news/bims-mitdis/...
Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite
www.nature.com/articles/s41...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social
biomed.news/bims-mitdis/...
Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite
www.nature.com/articles/s41...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
May 24, 2026 at 9:00 AM
New selection of papers on #Mitochondria in #Health & #Disease! 📚
biomed.news/bims-mitdis/...
Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite
www.nature.com/articles/s41...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social
biomed.news/bims-mitdis/...
Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite
www.nature.com/articles/s41...
@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social
Reposted by RyanLab_TCD
Identification of an STING inhibitor targeting the allosteric transmembrane domains
Identification of an STING inhibitor targeting the allosteric transmembrane domains
Chen et al. introduce Y-320, a potent allosteric STING inhibitor that uniquely binds to the transmembrane domain instead of the canonical binding pocket, thereby blocking STING activation and trafficking. Y-320 effectively improves acute kidney injury in mice, highlighting the therapeutic potential of targeting non-canonical STING sites.
dlvr.it
May 21, 2026 at 8:30 PM
Identification of an STING inhibitor targeting the allosteric transmembrane domains
🚨 We’re hiring! 🚨
1/n
I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️
Please share widely and see below for app details ⬇️
1/n
I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️
Please share widely and see below for app details ⬇️
May 18, 2026 at 3:02 PM
🚨 We’re hiring! 🚨
1/n
I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️
Please share widely and see below for app details ⬇️
1/n
I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️
Please share widely and see below for app details ⬇️
📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
biomed.news/bims-imicid/...
Interesting finding:
Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
May 17, 2026 at 2:11 PM
📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
biomed.news/bims-imicid/...
Interesting finding:
Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer
Reposted by RyanLab_TCD
New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/...
New tool
Universal conditional knockout approach to multiple species..
pubmed.ncbi.nlm.nih.gov/42132111/
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
New tool
Universal conditional knockout approach to multiple species..
pubmed.ncbi.nlm.nih.gov/42132111/
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
May 17, 2026 at 11:45 AM
New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/...
New tool
Universal conditional knockout approach to multiple species..
pubmed.ncbi.nlm.nih.gov/42132111/
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
New tool
Universal conditional knockout approach to multiple species..
pubmed.ncbi.nlm.nih.gov/42132111/
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social
#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 16, 2026 at 4:37 PM
#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
biomed.news/bims-imicid/...
Interesting finding:
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
May 12, 2026 at 9:51 AM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
biomed.news/bims-imicid/...
Interesting finding:
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.
May 7, 2026 at 8:34 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.
I’m delighted to share this news and grateful to the
@wellcometrust.bsky.social for supporting our work.
We will soon be recruiting for both a Research Associate and Research Assistant position.
More details will follow shortly, but please feel free to get in touch!
www.tcd.ie/news_events/...
@wellcometrust.bsky.social for supporting our work.
We will soon be recruiting for both a Research Associate and Research Assistant position.
More details will follow shortly, but please feel free to get in touch!
www.tcd.ie/news_events/...
Trinity scientist aims to demystify debilitating inherited conditions and pinpoint new treatment options
Dr Dylan Ryan will pursue the research after securing a highly competitive Wellcome Career Development Award valued at around €2.5 million.
www.tcd.ie
May 5, 2026 at 11:57 AM
I’m delighted to share this news and grateful to the
@wellcometrust.bsky.social for supporting our work.
We will soon be recruiting for both a Research Associate and Research Assistant position.
More details will follow shortly, but please feel free to get in touch!
www.tcd.ie/news_events/...
@wellcometrust.bsky.social for supporting our work.
We will soon be recruiting for both a Research Associate and Research Assistant position.
More details will follow shortly, but please feel free to get in touch!
www.tcd.ie/news_events/...