Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
go.nature.com/496nEob
Erythropoietin receptor on cDC1s dictates immune tolerance - Nature
The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.
go.nature.com
December 17, 2025 at 9:11 AM
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
go.nature.com/496nEob
Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 10, 2025 at 8:45 PM
Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
November 14, 2025 at 3:39 AM
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
Spotlight @cp-immunity.bsky.social on report in @nature.com
Erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer
www.cell.com/immunity/ful...
www.nature.com/articles/s41...
Erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer
www.cell.com/immunity/ful...
www.nature.com/articles/s41...
Doping cDC1s for tolerance
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have
been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce
immune tolerance remains ...
www.cell.com
February 13, 2026 at 7:15 PM
Spotlight @cp-immunity.bsky.social on report in @nature.com
Erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer
www.cell.com/immunity/ful...
www.nature.com/articles/s41...
Erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer
www.cell.com/immunity/ful...
www.nature.com/articles/s41...
Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
November 28, 2024 at 12:04 PM
Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
🤔Do you think that OXPHOS in DCs = tolerance?
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky
April 18, 2026 at 7:38 AM
🤔Do you think that OXPHOS in DCs = tolerance?
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky
Does mitochondrial respiration in DCs just “fuel” activation?
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
May 25, 2026 at 9:11 PM
Does mitochondrial respiration in DCs just “fuel” activation?
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s
www.science.org/doi/10.1126/...
At: CNIC_CARDIO
@inmunosky
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
www.nature.com
January 2, 2026 at 7:19 PM
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
#immunosky #epw2025 Fantastic presentation by Steffi Wculek @irbbarcelona.org showing on how #macrophages use OXPHOS for lipid processing (enclosed publication). New data on cDC1s regulating their immunogenicity through metabolite regulation by OXPHOS balance. www.sciencedirect.com/science/arti...
March 26, 2025 at 2:29 PM
#immunosky #epw2025 Fantastic presentation by Steffi Wculek @irbbarcelona.org showing on how #macrophages use OXPHOS for lipid processing (enclosed publication). New data on cDC1s regulating their immunogenicity through metabolite regulation by OXPHOS balance. www.sciencedirect.com/science/arti...
#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
doi.org
January 3, 2026 at 4:13 PM
#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!
Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪
Delighted that our paper describing cDC1 states and their distribution in mouse tumours is out today in @eurjimmunol.bsky.social. Many congratulations to Cécile Piot who led this work and brought it to conclusion! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
August 4, 2025 at 8:25 AM
Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪
🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
June 22, 2025 at 5:42 PM
🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why…
Check out the new study from @victor-bosteels.bsky.social, published in @natcomms.nature.com
in press @https://rdcu.be/fur4Q
Check out the new study from @victor-bosteels.bsky.social, published in @natcomms.nature.com
in press @https://rdcu.be/fur4Q
July 19, 2026 at 10:26 AM
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why…
Check out the new study from @victor-bosteels.bsky.social, published in @natcomms.nature.com
in press @https://rdcu.be/fur4Q
Check out the new study from @victor-bosteels.bsky.social, published in @natcomms.nature.com
in press @https://rdcu.be/fur4Q
WeekendRead! @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social &co show @science.org that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...
www.science.org
December 21, 2024 at 3:52 PM
WeekendRead! @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social &co show @science.org that cDC1s & Rorgt APCs drive peripheral Tregs to dietary antigens, & that helminth infections increase the ratio of inflammatory cDC2 preventing tolerance induction!
🧪Your immune system is dependent on healthy mitochondria potential.
T-cells, which fight infections+tumours, need to have proper electron flow. When we age this becomes compromised, increases likelihood of illness. Mitochondria antioxidants can support electron flow.
www.cell.com/cell-metabol...
T-cells, which fight infections+tumours, need to have proper electron flow. When we age this becomes compromised, increases likelihood of illness. Mitochondria antioxidants can support electron flow.
www.cell.com/cell-metabol...
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells
How metabolism shapes dendritic cell (DC) immunogenicity is debated—while glycolysis
activates, OXPHOS implies tolerance. Heras-Murillo et al. find that ETC electron flow
primes cDC1s via redox/metabo...
www.cell.com
May 2, 2026 at 8:07 PM
🧪Your immune system is dependent on healthy mitochondria potential.
T-cells, which fight infections+tumours, need to have proper electron flow. When we age this becomes compromised, increases likelihood of illness. Mitochondria antioxidants can support electron flow.
www.cell.com/cell-metabol...
T-cells, which fight infections+tumours, need to have proper electron flow. When we age this becomes compromised, increases likelihood of illness. Mitochondria antioxidants can support electron flow.
www.cell.com/cell-metabol...
Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación.
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
July 25, 2025 at 9:32 AM
Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación.
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
NEW #preprint summary from @preprintclub.bsky.social - Jonathan Monteiro @mironlab.bsky.social reviews @biorxiv-immuno.bsky.social preprint from Hu et al. showing that cDC1s enable CD8 T cell responses that exacerbate neurodegeneration in a mouse model of primary tauopathy
rdcu.be/fp89w
rdcu.be/fp89w
cDC1s license CD8+ T cell-mediated neurodegeneration
Nature Reviews Immunology - A preprint by Hu et al. shows, in a mouse model of primary tauopathy, that conventional type 1 dendritic cells outside of the central nervous system prime CD8+ T cells...
rdcu.be
June 24, 2026 at 8:26 AM
NEW #preprint summary from @preprintclub.bsky.social - Jonathan Monteiro @mironlab.bsky.social reviews @biorxiv-immuno.bsky.social preprint from Hu et al. showing that cDC1s enable CD8 T cell responses that exacerbate neurodegeneration in a mouse model of primary tauopathy
rdcu.be/fp89w
rdcu.be/fp89w
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:43 PM
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
Check out our latest review👏! We dive deep into how cDC1s orchestrate anti-tumor immunity through cross-presentation, immune networking, and spatial organization.
Ward, Kar, Balan, and Bhardwaj @bhardwajlab.bsky.social review how conventional type 1 #DendriticCells (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. rupress.org/jem/article/...
#CancerFocus #Immunotherapy
#CancerFocus #Immunotherapy
June 10, 2026 at 4:55 PM
Check out our latest review👏! We dive deep into how cDC1s orchestrate anti-tumor immunity through cross-presentation, immune networking, and spatial organization.
Stanford researchers found that dendritic cells need the erythropoietin receptor to promote immune tolerance.
Without it, these cells fail to induce regulatory T cells, suggesting a key role in controlling autoimmune disease.
www.nature.com/articles/s41...
Without it, these cells fail to induce regulatory T cells, suggesting a key role in controlling autoimmune disease.
www.nature.com/articles/s41...
Erythropoietin receptor on cDC1s dictates immune tolerance - Nature
The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing r...
www.nature.com
December 10, 2025 at 4:17 PM
Stanford researchers found that dendritic cells need the erythropoietin receptor to promote immune tolerance.
Without it, these cells fail to induce regulatory T cells, suggesting a key role in controlling autoimmune disease.
www.nature.com/articles/s41...
Without it, these cells fail to induce regulatory T cells, suggesting a key role in controlling autoimmune disease.
www.nature.com/articles/s41...
cDC1s license CD8+ T cell-mediated neurodegeneration
cDC1s license CD8+ T cell-mediated neurodegeneration
Nature Reviews Immunology, Published online: 22 June 2026; doi:10.1038/s41577-026-01329-8A preprint by Hu et al. shows, in a mouse model of primary tauopathy, that conventional type 1 dendritic cells outside of the central nervous system prime CD8+ T cells against brain-derived antigens, which exacerbate neurodegeneration.
dlvr.it
June 22, 2026 at 5:16 PM
cDC1s license CD8+ T cell-mediated neurodegeneration
ICYMI: cDC1s license CD8+ T cell-mediated neurodegeneration
cDC1s license CD8+ T cell-mediated neurodegeneration
Nature Reviews Immunology, Published online: 22 June 2026; doi:10.1038/s41577-026-01329-8A preprint by Hu et al. shows, in a mouse model of primary tauopathy, that conventional type 1 dendritic cells outside of the central nervous system prime CD8+ T cells against brain-derived antigens, which exacerbate neurodegeneration.
dlvr.it
June 23, 2026 at 5:17 PM
ICYMI: cDC1s license CD8+ T cell-mediated neurodegeneration
👏 We're thrilled to congratulate Dr. Claudia Mickael on her compelling abstract presentation:
“CD301b⁺ cDC2s, but not Batf3⁺ cDC1s, Mediate Hypoxia-Induced Pulmonary Hypertension via Subset-Specific Activation Programs”.
@ats-pc.bsky.social
“CD301b⁺ cDC2s, but not Batf3⁺ cDC1s, Mediate Hypoxia-Induced Pulmonary Hypertension via Subset-Specific Activation Programs”.
@ats-pc.bsky.social
September 6, 2025 at 2:18 PM
👏 We're thrilled to congratulate Dr. Claudia Mickael on her compelling abstract presentation:
“CD301b⁺ cDC2s, but not Batf3⁺ cDC1s, Mediate Hypoxia-Induced Pulmonary Hypertension via Subset-Specific Activation Programs”.
@ats-pc.bsky.social
“CD301b⁺ cDC2s, but not Batf3⁺ cDC1s, Mediate Hypoxia-Induced Pulmonary Hypertension via Subset-Specific Activation Programs”.
@ats-pc.bsky.social