Susan Lea
@smlea.bsky.social
Scientist at St Jude using structural biology to try and understand how things work - views are my own not my institutions
Reposted by Susan Lea
On a personal note, I took a similar position in 2018 and haven’t looked back since! Applicants are welcome to get in touch with me for an informal chat.
August 10, 2026 at 8:33 PM
On a personal note, I took a similar position in 2018 and haven’t looked back since! Applicants are welcome to get in touch with me for an informal chat.
Reposted by Susan Lea
The successful candidate will be a member of the Department of Chemistry, ultimately teaching on the Biochemistry and Chemistry degree programs. It is roughly equivalent to a tenure-track assistant professor position in the US.
August 10, 2026 at 8:33 PM
The successful candidate will be a member of the Department of Chemistry, ultimately teaching on the Biochemistry and Chemistry degree programs. It is roughly equivalent to a tenure-track assistant professor position in the US.
Reposted by Susan Lea
YSBL has a research culture that is both supportive and ambitious, which we are all enormously proud of. It is also an environment where people readily work together to achieve more than they could alone. To me, it’s a special place to work.
August 10, 2026 at 8:33 PM
YSBL has a research culture that is both supportive and ambitious, which we are all enormously proud of. It is also an environment where people readily work together to achieve more than they could alone. To me, it’s a special place to work.
Reposted by Susan Lea
YSBL is also well equipped for crystallography and protein NMR. Beyond YSBL, the Bioscience Technology Facility houses brilliant facilities for light microscopy, mass spec, and biophysics (amongst many other things!).
August 10, 2026 at 8:33 PM
YSBL is also well equipped for crystallography and protein NMR. Beyond YSBL, the Bioscience Technology Facility houses brilliant facilities for light microscopy, mass spec, and biophysics (amongst many other things!).
Reposted by Susan Lea
Our Cryo-EM facility, supported by expert technical staff (Johan Turkenburg and Sam Hart), is housed in the custom-built Dodsons Building and has an energy-filter equipped Glacios and an incoming FIB-mill.
August 10, 2026 at 8:33 PM
Our Cryo-EM facility, supported by expert technical staff (Johan Turkenburg and Sam Hart), is housed in the custom-built Dodsons Building and has an energy-filter equipped Glacios and an incoming FIB-mill.
Reposted by Susan Lea
The successful candidate will be a member of the York Structural Biology Laboratory (YSBL), a research centre build around ~15 structural biology groups from the Departments of Chemistry and Biology.
August 10, 2026 at 8:33 PM
The successful candidate will be a member of the York Structural Biology Laboratory (YSBL), a research centre build around ~15 structural biology groups from the Departments of Chemistry and Biology.
Reposted by Susan Lea
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
Jobs - The University of York
jobs.york.ac.uk
August 10, 2026 at 8:33 PM
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
So everyone should want to work @stjuderesearch.bsky.social! Less than 24 hours after the request we have the football on the big screen!
June 18, 2026 at 5:42 PM
So everyone should want to work @stjuderesearch.bsky.social! Less than 24 hours after the request we have the football on the big screen!
The English, Croatians and honorary Croatians gather @stjuderesearch.bsky.social
June 17, 2026 at 8:26 PM
The English, Croatians and honorary Croatians gather @stjuderesearch.bsky.social
Reposted by Susan Lea
Excited to announce that our research group will be joining the St. Jude Children's Research Hospital Department of Chemical Biology & Therapeutics in September. 🥼 🧬 🧪 @stjuderesearch.bsky.social
June 16, 2026 at 5:38 PM
Excited to announce that our research group will be joining the St. Jude Children's Research Hospital Department of Chemical Biology & Therapeutics in September. 🥼 🧬 🧪 @stjuderesearch.bsky.social
A lot of work, over many years, and we finally see the missing piece at the heart of type 3 export!
Structure of the proton-powered secretion motor at the heart of the bacterial flagellum www.biorxiv.org/content/10.64898/2026.06.13.732081v1 #cryoem
June 16, 2026 at 4:53 PM
A lot of work, over many years, and we finally see the missing piece at the heart of type 3 export!
Reposted by Susan Lea
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work!
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
Structural basis for prostaglandin and drug transport via SLCO2A1
Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...
www.nature.com
March 20, 2026 at 11:15 AM
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work!
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
Reposted by Susan Lea
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
mrc.tal.net
February 16, 2026 at 12:09 PM
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens: Cell www.cell.com/cell/fulltex...
Excited to share our collaborative work with the Wolin group examining RNA folding
Excited to share our collaborative work with the Wolin group examining RNA folding
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Structural and functional analyses elucidate the mechanisms by which two ATP-independent
RNA chaperones, Ro60 and La, recognize and unfold misfolded RNAs. Diverse noncoding
RNAs are associated with th...
www.cell.com
February 6, 2026 at 8:21 PM
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens: Cell www.cell.com/cell/fulltex...
Excited to share our collaborative work with the Wolin group examining RNA folding
Excited to share our collaborative work with the Wolin group examining RNA folding
#StJudeResearch Paul Taylor reminding us that mission is where it all starts
February 6, 2026 at 4:35 PM
#StJudeResearch Paul Taylor reminding us that mission is where it all starts
#StJudeResearch - Jim Downing reminds us of the founding documents for St Jude placing research at the heart of new treatments for catastrophic childhood disease - knowledge generation as our core activity
February 6, 2026 at 4:35 PM
#StJudeResearch - Jim Downing reminds us of the founding documents for St Jude placing research at the heart of new treatments for catastrophic childhood disease - knowledge generation as our core activity
and apparently reanimation as well as Elvis will be in the house later..the full Memphis experience for my first Faculty Retreat #StJudeResearch
February 6, 2026 at 4:33 PM
and apparently reanimation as well as Elvis will be in the house later..the full Memphis experience for my first Faculty Retreat #StJudeResearch
Reposted by Susan Lea
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
doi.org
October 2, 2025 at 6:20 AM
Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Susan Lea
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress - Nature Communications
Actinobacteria grow by inserting new cell wall material at the cell poles. Here, Zhong et al. show that a stomatin-like protein modulates polar growth under hyperosmotic stress by facilitating the for...
www.nature.com
March 18, 2025 at 6:27 PM
Congratulations to Xiaobo @xiaobozhong.bsky.social on his great paper! www.nature.com/articles/s41...
Reposted by Susan Lea
Reposted by Susan Lea
Last few days to apply for this:
There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
March 7, 2025 at 1:33 PM
Last few days to apply for this:
Reposted by Susan Lea
Less than half an hour ago, a peaceful transfer of power has taken place at #BPS2025!
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
February 18, 2025 at 5:44 PM
Less than half an hour ago, a peaceful transfer of power has taken place at #BPS2025!
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Join me in welcoming Madam President of the @biophysicalsoc.bsky.social, Professor Lynnmarie Thompson!
And Madam President Elect, Professor Karen Fleming!
👏👏👏👏👏
Reposted by Susan Lea
A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota https://www.biorxiv.org/content/10.1101/2025.02.17.638638v1
February 18, 2025 at 2:17 AM
A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota https://www.biorxiv.org/content/10.1101/2025.02.17.638638v1
Reposted by Susan Lea
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
January 26, 2025 at 1:30 PM
It really is amazing. Another related point is that Academia wouldn't actually be doing its job if it *didn't* send the bulk of its knowledge and highly trained individuals into other parts of society.
Reposted by Susan Lea
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out
January 26, 2025 at 12:27 PM
Also, it is a pyramidal structure. Not all post docs can progress to become PIs. I would wish that there were some mid-level permanent staff scientist positions for those that would like to continue bench work instead of taking a more administrative role as PI, but as things are now, it is PI or out