Tommy Vierbuchen
@tvierbuchen.bsky.social
VP Research at Cellular Intelligence. Formerly Assistant Professor Dev Bio Program + Center for Stem Cell Biology at Sloan Kettering.
cellularintelligence.com
cellularintelligence.com
Pinned
Tommy Vierbuchen
@tvierbuchen.bsky.social
· Aug 27
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Reposted by Tommy Vierbuchen
NEW PREPRINT!
An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
September 21, 2026 at 4:15 PM
NEW PREPRINT!
An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
Reposted by Tommy Vierbuchen
Hypothalamic Cell Type Evolution across Vertebrates https://www.biorxiv.org/content/10.64898/2026.08.23.746350v1
August 27, 2026 at 1:30 AM
Hypothalamic Cell Type Evolution across Vertebrates https://www.biorxiv.org/content/10.64898/2026.08.23.746350v1
Reposted by Tommy Vierbuchen
New preprints! 1/3
Spider venom glands are modified salivary glands which have recruited appendage and myogenic programs from other the developmental programs of other organs. Led by Giulia Zancolli, with @yehumoran.bsky.social
doi.org/10.64898/202...
Spider venom glands are modified salivary glands which have recruited appendage and myogenic programs from other the developmental programs of other organs. Led by Giulia Zancolli, with @yehumoran.bsky.social
doi.org/10.64898/202...
July 29, 2026 at 2:49 PM
New preprints! 1/3
Spider venom glands are modified salivary glands which have recruited appendage and myogenic programs from other the developmental programs of other organs. Led by Giulia Zancolli, with @yehumoran.bsky.social
doi.org/10.64898/202...
Spider venom glands are modified salivary glands which have recruited appendage and myogenic programs from other the developmental programs of other organs. Led by Giulia Zancolli, with @yehumoran.bsky.social
doi.org/10.64898/202...
I am excited to announce that I have joined Cellular Intelligence as VP Research. Looking forward to working with their world-class team to develop new approaches for understanding and manipulating stem cell fate decisions.
www.cellularintelligence.com
www.cellularintelligence.com
Cellular Intelligence
We are building a future where biology is no longer destiny, but design.
www.cellularintelligence.com
July 7, 2026 at 8:06 PM
I am excited to announce that I have joined Cellular Intelligence as VP Research. Looking forward to working with their world-class team to develop new approaches for understanding and manipulating stem cell fate decisions.
www.cellularintelligence.com
www.cellularintelligence.com
Reposted by Tommy Vierbuchen
Think I might have chosen the experts at one of the worlds most admired zoos *that has been doing this for 50 years*.
June 25, 2026 at 3:15 PM
Think I might have chosen the experts at one of the worlds most admired zoos *that has been doing this for 50 years*.
Nice write up by Ian Demsky about our work as part of the NIH MORPHIC Consortium together with @studerl.bsky.social, @danweihuangfu.bsky.social, and Ting Zhou labs.
www.mskcc.org/news/morphic...
www.mskcc.org/news/morphic...
MorPhiC: Inside the Ambitious Project To Understand the Function of Every Human Gene | Memorial Sloan Kettering Cancer Center
MSK scientists are part of an international consortium working to determine the biological functions of the roughly 20,000 protein-coding genes in the human genome.
www.mskcc.org
June 23, 2026 at 1:07 AM
Nice write up by Ian Demsky about our work as part of the NIH MORPHIC Consortium together with @studerl.bsky.social, @danweihuangfu.bsky.social, and Ting Zhou labs.
www.mskcc.org/news/morphic...
www.mskcc.org/news/morphic...
Reposted by Tommy Vierbuchen
IMPORTANT study from @hocinerekaik.bsky.social @denisduboule.bsky.social and a significant validation of SCBEMs, #gastruloids in particular, as a discovery tool www.biorxiv.org/content/10.6...
🧵
🧵
June 21, 2026 at 12:38 PM
IMPORTANT study from @hocinerekaik.bsky.social @denisduboule.bsky.social and a significant validation of SCBEMs, #gastruloids in particular, as a discovery tool www.biorxiv.org/content/10.6...
🧵
🧵
Reposted by Tommy Vierbuchen
This perspective piece reviews new omics, developmental genetic, and cell lineage studies to critically review current models of developing forebrain organization. Spoiler: there are _serious_ problems with the prosomere model.
Well done to @elsieplace.bsky.social, Marysia Placzek and @sethblackshaw.bsky.social for this beautifully clear overview of a very complex history of brain developmental models
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reassessing forebrain organization: recent evidence challenges the prosomere model
For over three decades, the prosomere model has influenced our understanding of vertebrate brain development by proposing that the forebrain consists …
www.sciencedirect.com
June 11, 2026 at 7:31 PM
This perspective piece reviews new omics, developmental genetic, and cell lineage studies to critically review current models of developing forebrain organization. Spoiler: there are _serious_ problems with the prosomere model.
Reposted by Tommy Vierbuchen
(1/15)
Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
www.biorxiv.org
May 5, 2026 at 11:41 AM
(1/15)
Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
Reposted by Tommy Vierbuchen
New Preprint alert!🚨
Super excited to share my postdoc work now on BioRxiv.
How does PRC2 loss lead to developmental failures?
We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬.
Preprint: doi.org/10.64898/2026.04.18.719361
Super excited to share my postdoc work now on BioRxiv.
How does PRC2 loss lead to developmental failures?
We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬.
Preprint: doi.org/10.64898/2026.04.18.719361
April 24, 2026 at 8:58 AM
New Preprint alert!🚨
Super excited to share my postdoc work now on BioRxiv.
How does PRC2 loss lead to developmental failures?
We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬.
Preprint: doi.org/10.64898/2026.04.18.719361
Super excited to share my postdoc work now on BioRxiv.
How does PRC2 loss lead to developmental failures?
We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬.
Preprint: doi.org/10.64898/2026.04.18.719361
Reposted by Tommy Vierbuchen
I am excited to announce that I have received a Travel & Merit Award for the #ISSCR2026 Annual Meeting about my work modeling mouse cranial and cardiac neural crest development in vitro. Many thanks to my mentor @tvierbuchen.bsky.social for his guidance and support throughout this project @ISSCR.org
I'm attending the ISSCR 2026 Annual Meeting, join me
Register now
invt.io
April 22, 2026 at 3:21 PM
I am excited to announce that I have received a Travel & Merit Award for the #ISSCR2026 Annual Meeting about my work modeling mouse cranial and cardiac neural crest development in vitro. Many thanks to my mentor @tvierbuchen.bsky.social for his guidance and support throughout this project @ISSCR.org
Congrats to @annbaako.bsky.social for her successful thesis defense!! @justinperryphd.bsky.social and I are so proud of you!
Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon.
www.biorxiv.org/content/10.1...
Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon.
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 22, 2026 at 6:51 PM
Congrats to @annbaako.bsky.social for her successful thesis defense!! @justinperryphd.bsky.social and I are so proud of you!
Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon.
www.biorxiv.org/content/10.1...
Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon.
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 15, 2026 at 8:27 PM
AP-1 is both night science and day science
How does a cell learn? In our new perspective in @nature.com we propose a model where the properties of the AP-1 family of transcription factors – stress-induced feedback, regulatory combinatorics and cellular memory – encode a mechanism for cellular learning. www.nature.com/articles/s41...
April 15, 2026 at 8:22 PM
AP-1 is both night science and day science
Reposted by Tommy Vierbuchen
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org
April 13, 2026 at 4:51 AM
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
Reposted by Tommy Vierbuchen
For decades, molecular biology and human genetics have been built around measurements of average gene expression. That was partly conceptual, but also technological: for a long time, the mean was the quantity we could measure most reliably. Our new preprint argues that this framework is incomplete.
April 4, 2026 at 4:02 PM
For decades, molecular biology and human genetics have been built around measurements of average gene expression. That was partly conceptual, but also technological: for a long time, the mean was the quantity we could measure most reliably. Our new preprint argues that this framework is incomplete.
Reposted by Tommy Vierbuchen
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 1, 2026 at 8:05 PM
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
Example #314:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....
www.science.org
March 26, 2026 at 9:19 PM
Example #314:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Tommy Vierbuchen
👀 Absolute banger paper. Leveraging cattle/pig GWAS/eQTL to help explain the missing regulatory gap in humans. Consistent with previous works, selection makes identifying relevant eQTLs in humans challenging.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 25, 2026 at 4:32 PM
👀 Absolute banger paper. Leveraging cattle/pig GWAS/eQTL to help explain the missing regulatory gap in humans. Consistent with previous works, selection makes identifying relevant eQTLs in humans challenging.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
AP-1 transcription factors do everything, example #312.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
www.nature.com
March 25, 2026 at 5:19 PM
AP-1 transcription factors do everything, example #312.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Tommy Vierbuchen
Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey.
bsdb.org/2026/03/24/2...
bsdb.org/2026/03/24/2...
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
bsdb.org
March 25, 2026 at 7:27 AM
Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey.
bsdb.org/2026/03/24/2...
bsdb.org/2026/03/24/2...
Reposted by Tommy Vierbuchen
Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology.
bsdb.org/2026/03/24/2...
bsdb.org/2026/03/24/2...
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
bsdb.org
March 24, 2026 at 7:47 PM
Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology.
bsdb.org/2026/03/24/2...
bsdb.org/2026/03/24/2...
Reposted by Tommy Vierbuchen
Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance.
www.cell.com/current-biol...
www.cell.com/current-biol...
Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans
Frejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in
the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms
and environmental variable...
www.cell.com
March 24, 2026 at 3:48 PM
Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance.
www.cell.com/current-biol...
www.cell.com/current-biol...