Seychelle Vos
@voslab.org
⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
September 8, 2026 at 5:25 PM
⚡Preprint alert⚡ So proud of @amohamed98.bsky.social! Abdallah determined the cryo-EM structure of BRD4 bound to the kinase P-TEFb, defining the molecular basis of this key transcription interaction — and revealing that BRD4 and AFF4 binding are mutually exclusive to P-TEFb. Lots more inside 👇
Reposted by Seychelle Vos
🧵 We’re excited to share our new bioRxiv preprint on how INO80 reads promoter-proximal DNA sequence features to position +1 nucleosomes 🧬
Amazing work by Mariia, Annika, and others! 🤩
🔗 www.biorxiv.org/content/10.6...
#ChromatinBiology #StructuralBiology #Nucleosome #INO80
Amazing work by Mariia, Annika, and others! 🤩
🔗 www.biorxiv.org/content/10.6...
#ChromatinBiology #StructuralBiology #Nucleosome #INO80
September 2, 2026 at 5:44 AM
🧵 We’re excited to share our new bioRxiv preprint on how INO80 reads promoter-proximal DNA sequence features to position +1 nucleosomes 🧬
Amazing work by Mariia, Annika, and others! 🤩
🔗 www.biorxiv.org/content/10.6...
#ChromatinBiology #StructuralBiology #Nucleosome #INO80
Amazing work by Mariia, Annika, and others! 🤩
🔗 www.biorxiv.org/content/10.6...
#ChromatinBiology #StructuralBiology #Nucleosome #INO80
Reposted by Seychelle Vos
Registration for this mechanisms of RNA Polymerase regulation meeting is Aug 2: u.osu.edu/mltermmeeting/
Mountain Lake Termination Meeting
u.osu.edu
July 21, 2026 at 5:38 PM
Registration for this mechanisms of RNA Polymerase regulation meeting is Aug 2: u.osu.edu/mltermmeeting/
Your cryo-EM work deserves to be seen 🔬 Submit your poster or talk abstract for the annual New England cryo-EM symposium by July 15th. The meeting will be held September 8th at MIT. This is the place to be if you are doing structural biology in the Northeast! Register: cryoem.mit.edu/2026-ne-cryo...
July 1, 2026 at 9:18 PM
Your cryo-EM work deserves to be seen 🔬 Submit your poster or talk abstract for the annual New England cryo-EM symposium by July 15th. The meeting will be held September 8th at MIT. This is the place to be if you are doing structural biology in the Northeast! Register: cryoem.mit.edu/2026-ne-cryo...
Reposted by Seychelle Vos
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
June 22, 2026 at 3:32 PM
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.
🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time.
tinyurl.com/ELOF1
tinyurl.com/ELOF1
May 29, 2026 at 5:36 PM
⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.
Reposted by Seychelle Vos
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 18, 2026 at 4:16 PM
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Seychelle Vos
Preprint alert 🚨Happy to share my first Posdoc manuscript from the Vos lab @voslab.org. We introduce GATO-seq, a high-throughput, fully in vitro technique that maps RNA polymerases at base pair resolution over time. Using it, we found a new pause state of Pol II: sidetracking tinyurl.com/superpause
February 19, 2026 at 2:55 PM
Preprint alert 🚨Happy to share my first Posdoc manuscript from the Vos lab @voslab.org. We introduce GATO-seq, a high-throughput, fully in vitro technique that maps RNA polymerases at base pair resolution over time. Using it, we found a new pause state of Pol II: sidetracking tinyurl.com/superpause
🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause
February 19, 2026 at 2:23 PM
🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
February 12, 2026 at 2:03 PM
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 12:54 PM
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
Reposted by Seychelle Vos
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 18, 2025 at 2:44 PM
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
I wrote an opinion piece for my hometown South Carolina newspaper that was published today. Support science funding for our future! Standing up for science today and always! tinyurl.com/mr3vuphr
Page A04
View the The Journal for Friday, March 7, 2025
tinyurl.com
March 7, 2025 at 12:31 PM
I wrote an opinion piece for my hometown South Carolina newspaper that was published today. Support science funding for our future! Standing up for science today and always! tinyurl.com/mr3vuphr
Reposted by Seychelle Vos
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 29, 2025 at 4:29 PM
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
The short talk abstract and scholarship deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation is tomorrow (23 January)! Get your abstracts in to be part of a great meeting in Banff this spring. @keystonesymposia.bsky.social keysym.us/KSChromatin25
January 22, 2025 at 7:21 PM
The short talk abstract and scholarship deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation is tomorrow (23 January)! Get your abstracts in to be part of a great meeting in Banff this spring. @keystonesymposia.bsky.social keysym.us/KSChromatin25
Reposted by Seychelle Vos
Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!
The ⏰ is ticking to submit your abstract or scholarship application for a chance to present a short talk at our Epigenetics meeting. Make sure to send them in by 11:59 PM MST on January 9th!
keysym.us/KSEpigenetic...
#KSEpigenetics25 #epigenetics #humandevelopment #developmentalbiology
keysym.us/KSEpigenetic...
#KSEpigenetics25 #epigenetics #humandevelopment #developmentalbiology
January 7, 2025 at 6:52 AM
Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!
Start off the New Year on a high note and submit your abstract for @KeystoneSymp Interplay of #Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away on January 9th! tinyurl.com/txn-keystone #KSChromatin25
KSQA: Dr. Seychelle M. Vos (Interplay of Chromatin Architecture)
YouTube video by KeystoneSymposia
www.youtube.com
January 2, 2025 at 8:07 PM
Start off the New Year on a high note and submit your abstract for @KeystoneSymp Interplay of #Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away on January 9th! tinyurl.com/txn-keystone #KSChromatin25
Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
The structural basis for RNA slicing by human Argonaute2
Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.
tinyurl.com
January 1, 2025 at 5:03 PM
Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
December 31, 2024 at 3:23 PM
Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting. Join us in Banff for some awesome science. #KSChromatin25
November 21, 2024 at 5:06 PM
The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting. Join us in Banff for some awesome science. #KSChromatin25