Aaron Klausnitzer
@aklausnitzer.bsky.social
PhD student @ Glaubitz lab / membrane transport proteins / lipopolysaccharide transport / solid-state NMR #sfb1507
Pinned
Conformational Plasticity of LptC Regulates Lipopolysaccharide Transport by the LptB2FGC Complex
The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport be...
doi.org
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
How do ABC transporter domains communicate with each other?
In our new study we adressed this question using the type VI ABC transporter of the lipopolysaccharide transport system and 19F ultrafast MAS NMR.
Thanks to everyone involved in this project!
Here is the preprint:
In our new study we adressed this question using the type VI ABC transporter of the lipopolysaccharide transport system and 19F ultrafast MAS NMR.
Thanks to everyone involved in this project!
Here is the preprint:
Conformational selection drives substrate-ATP coupling in the type VI ABC transporter
The mechanism of substrate-ATP coupling is central to the function of ABC transporters. Substrates bind to the specialized transmembrane domains (TMDs), whereas ATP binding and hydrolysis occur in the...
www.biorxiv.org
August 17, 2026 at 9:52 AM
How do ABC transporter domains communicate with each other?
In our new study we adressed this question using the type VI ABC transporter of the lipopolysaccharide transport system and 19F ultrafast MAS NMR.
Thanks to everyone involved in this project!
Here is the preprint:
In our new study we adressed this question using the type VI ABC transporter of the lipopolysaccharide transport system and 19F ultrafast MAS NMR.
Thanks to everyone involved in this project!
Here is the preprint:
Reposted by Aaron Klausnitzer
📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
A dynamic displacement mechanism drives protein import into mitochondria
Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...
www.biorxiv.org
January 14, 2026 at 7:16 PM
📢 New preprint alert!
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code.
www.biorxiv.org/content/10.6...
#StructuralBiology #Mitochondria
🧵 1/8
Reposted by Aaron Klausnitzer
22nd of December and I already got my first Christmas present 🎁
My first paper has been published in NAR as a Breakthrough article and I’m beyond excited ✨
A big thanks to everyone involved in this project, especially Jens Wöhnert and Hermann Schindelin @en-hxnu-enment.bsky.social !
My first paper has been published in NAR as a Breakthrough article and I’m beyond excited ✨
A big thanks to everyone involved in this project, especially Jens Wöhnert and Hermann Schindelin @en-hxnu-enment.bsky.social !
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
December 22, 2025 at 5:39 PM
22nd of December and I already got my first Christmas present 🎁
My first paper has been published in NAR as a Breakthrough article and I’m beyond excited ✨
A big thanks to everyone involved in this project, especially Jens Wöhnert and Hermann Schindelin @en-hxnu-enment.bsky.social !
My first paper has been published in NAR as a Breakthrough article and I’m beyond excited ✨
A big thanks to everyone involved in this project, especially Jens Wöhnert and Hermann Schindelin @en-hxnu-enment.bsky.social !
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
Conformational Plasticity of LptC Regulates Lipopolysaccharide Transport by the LptB2FGC Complex
The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport be...
doi.org
September 23, 2025 at 5:30 PM
Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:
doi.org/10.1021/jacs...
doi.org/10.1021/jacs...
Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲
Conformational plasticity of LptC regulates lipopolysaccharide transportby the LptB2FGC complex https://www.biorxiv.org/content/10.1101/2025.07.09.663713v1
July 12, 2025 at 4:58 PM
Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲
Reposted by Aaron Klausnitzer
Proud to share this great story is out now! A huge Thank You to the whole team but especially to my co-first author Janina Stautz. The results were often surprising but we managed to unpuzzle how a short IDR and its membrane interaction are involved in channel opening.
This took us a while and I am all the happier it is finally out! I thought that simply adding ATP to purified potassium channel KtrAB should be sufficient to stabilize its active state. I was so wrong...
Read the full story on how an IDR facilitates channel opening upon membrane interaction.
Read the full story on how an IDR facilitates channel opening upon membrane interaction.
A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB
Nature Communications - KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus...
www.nature.com
May 13, 2025 at 7:04 AM
Proud to share this great story is out now! A huge Thank You to the whole team but especially to my co-first author Janina Stautz. The results were often surprising but we managed to unpuzzle how a short IDR and its membrane interaction are involved in channel opening.
Reposted by Aaron Klausnitzer
So proud that our very own Victor won a poster award for his amazing work on bidirectional coupling in an ABC transporter at #ABC2025!
😍🥳🥳🥳🥳
read more here:
www.biorxiv.org/content/10.1...
😍🥳🥳🥳🥳
read more here:
www.biorxiv.org/content/10.1...
March 3, 2025 at 6:25 PM
So proud that our very own Victor won a poster award for his amazing work on bidirectional coupling in an ABC transporter at #ABC2025!
😍🥳🥳🥳🥳
read more here:
www.biorxiv.org/content/10.1...
😍🥳🥳🥳🥳
read more here:
www.biorxiv.org/content/10.1...
I‘m happy that i could share my project on this years #ABC2025😊
After a great talk from Agatha Tymczak from Voula Kanelis lab using solution NMR on SUR1, @aklausnitzer.bsky.social presenting now on the power of solid-state NMR to study ABC transporters! #ABC2025
And chair Maki Tsujita keeping everyone on time 😅
And chair Maki Tsujita keeping everyone on time 😅
February 28, 2025 at 6:34 PM
I‘m happy that i could share my project on this years #ABC2025😊
Reposted by Aaron Klausnitzer
Hello Bluesky, excited to be here🌟 For my first post, I wanted to share our recent collaboration, which I was very happy to contribute to. Our findings indicate that Camalexin could serve as a promising scaffold for developing potent inhibitors against AcrB. Have a read here: doi.org/10.1016/j.bi...
Redirecting
doi.org
January 29, 2025 at 10:31 AM
Hello Bluesky, excited to be here🌟 For my first post, I wanted to share our recent collaboration, which I was very happy to contribute to. Our findings indicate that Camalexin could serve as a promising scaffold for developing potent inhibitors against AcrB. Have a read here: doi.org/10.1016/j.bi...