Anna Nemudraia
@anemudraia.bsky.social
Doing my best and a bit of science.
UF CoM, https://nemudryi-lab.com
https://scholar.google.com/citations?hl=en&user=bYnnCoEAAAAJ&view_op=list_works&sortby=pubdate
UF CoM, https://nemudryi-lab.com
https://scholar.google.com/citations?hl=en&user=bYnnCoEAAAAJ&view_op=list_works&sortby=pubdate
Reposted by Anna Nemudraia
Happy to share our latest pre-print on the Druantia defense system.
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
www.biorxiv.org
May 14, 2026 at 7:02 AM
Happy to share our latest pre-print on the Druantia defense system.
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
Reposted by Anna Nemudraia
‼️Please share‼️
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
University of Florida - Details - Postdoctoral Associate
explore.jobs.ufl.edu
April 8, 2026 at 9:58 PM
‼️Please share‼️
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
Nemudryi lab is looking for postdocs to join our team and study:
🦠 Bacterial phage defense mechanisms
🧬 RNA repair & CRISPR-based RNA editing
Excited about RNA, host-virus interactions & mechanistic biology?
Let's talk!
Apply: explore.jobs.ufl.edu/en-us/job/53...
Reposted by Anna Nemudraia
Bacterial Schlafen proteins mediate phage defence
(new work from @anemudraia.bsky.social and @artemnemudryi.bsky.social labs)
www.nature.com/articles/s41...
Schlafens are an ancient, mechanistically conserved family of tRNA-targeting immune effectors.
(new work from @anemudraia.bsky.social and @artemnemudryi.bsky.social labs)
www.nature.com/articles/s41...
Schlafens are an ancient, mechanistically conserved family of tRNA-targeting immune effectors.
Bacterial Schlafen proteins mediate phage defence - Nature Microbiology
This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.
www.nature.com
March 11, 2026 at 4:38 AM
Bacterial Schlafen proteins mediate phage defence
(new work from @anemudraia.bsky.social and @artemnemudryi.bsky.social labs)
www.nature.com/articles/s41...
Schlafens are an ancient, mechanistically conserved family of tRNA-targeting immune effectors.
(new work from @anemudraia.bsky.social and @artemnemudryi.bsky.social labs)
www.nature.com/articles/s41...
Schlafens are an ancient, mechanistically conserved family of tRNA-targeting immune effectors.
Reposted by Anna Nemudraia
Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com!
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
March 9, 2026 at 4:13 PM
Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com!
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
Check out the final version here:
rdcu.be/e7Bmz
We are looking for postdocs and students to expand our team! Official postings are coming soon.
Please reach out if you're interested!
#phage #phagesky #microsky
Reposted by Anna Nemudraia
Exciting times ahead!
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
August 18, 2025 at 2:54 PM
Exciting times ahead!
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Reposted by Anna Nemudraia
New preprint from the Wiedenheft lab!
We used #cryoEM to show how a type I-F #CRISPR integrase captures, delivers, and integrates foreign DNA.
www.biorxiv.org/content/10.1...
We used #cryoEM to show how a type I-F #CRISPR integrase captures, delivers, and integrates foreign DNA.
www.biorxiv.org/content/10.1...
June 18, 2025 at 1:21 AM
New preprint from the Wiedenheft lab!
We used #cryoEM to show how a type I-F #CRISPR integrase captures, delivers, and integrates foreign DNA.
www.biorxiv.org/content/10.1...
We used #cryoEM to show how a type I-F #CRISPR integrase captures, delivers, and integrates foreign DNA.
www.biorxiv.org/content/10.1...
Reposted by Anna Nemudraia
First preprint from the Nemudryi Lab! 🍾
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
Bacterial Schlafens mediate anti-phage defense
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
www.biorxiv.org
July 25, 2025 at 2:52 PM
First preprint from the Nemudryi Lab! 🍾
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
Reposted by Anna Nemudraia
@anemudraia.bsky.social and I are grateful to our very first team members, Veronica, Yimo, and Riley, who bravely joined the lab early on and worked hard on this project!
And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!
And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!
July 25, 2025 at 2:52 PM
@anemudraia.bsky.social and I are grateful to our very first team members, Veronica, Yimo, and Riley, who bravely joined the lab early on and worked hard on this project!
And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!
And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!
Reposted by Anna Nemudraia
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...