Arya Krishna
@aryakrishna.bsky.social
Studying single-molecule dynamics through nanopore technology
Membrane proteins, Biological nanopore
@MahendransGroup
@RGCB_Trivandrum
Membrane proteins, Biological nanopore
@MahendransGroup
@RGCB_Trivandrum
Reposted by Arya Krishna
New paper:
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism - Nature Nanotechnology
An engineered bionanopore enables single-molecule tracking of catecholamine biosynthesis from phenylalanine to adrenaline, revealing time-resolved pathway dynamics and showing how impaired dehalogenas...
www.nature.com
September 1, 2026 at 9:52 AM
New paper:
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Reposted by Arya Krishna
New paper:
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
"Tunable α-helical octameric #nanopores can be assembled from an engineered #peptide, enabling programmable biomolecular #sensing."
www.nature.com/articles/s41...
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
"Tunable α-helical octameric #nanopores can be assembled from an engineered #peptide, enabling programmable biomolecular #sensing."
www.nature.com/articles/s41...
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling - Nature Nanotechnology
An engineered peptide self-assembles into α-helical octameric flexible nanopores with tunable diameters and conductances, enabling conformationally programmable biomolecular sensing.
www.nature.com
August 28, 2026 at 9:25 AM
New paper:
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
"Tunable α-helical octameric #nanopores can be assembled from an engineered #peptide, enabling programmable biomolecular #sensing."
www.nature.com/articles/s41...
A self-assembled peptide forms α-helical nanopores for ultrasensitive biomarker profiling.
"Tunable α-helical octameric #nanopores can be assembled from an engineered #peptide, enabling programmable biomolecular #sensing."
www.nature.com/articles/s41...
Reposted by Arya Krishna
New Huang lab publication at Nature. Our newly developed technique: transient Pore Analyte Looping (tPAL) now achieves “chop and measure” nanopore sequencing of peptide, in an amino acid by amino acid manner. De novo nanopore peptide sequencing, we are finally here!! www.nature.com/articles/s41...
Sequential reading of a stepwise-shortened peptide immobilized on nanopore - Nature
A nanopore-based ‘chop and measure’ method sequences peptides at single-amino-acid resolution by using enzymatic digestion to progressively shorten the N terminus one residue at a time,...
www.nature.com
July 30, 2026 at 1:42 AM
New Huang lab publication at Nature. Our newly developed technique: transient Pore Analyte Looping (tPAL) now achieves “chop and measure” nanopore sequencing of peptide, in an amino acid by amino acid manner. De novo nanopore peptide sequencing, we are finally here!! www.nature.com/articles/s41...
Reposted by Arya Krishna
I can finally get this video posted on bluesky. This cartoon illustration should be more clear describing the newly developped transient Pore Analyte Looping (tPAL) platform and the "chop and measure" mode for nanopore protein sequencing. @nature.com www.nature.com/articles/s41...
August 2, 2026 at 2:12 AM
I can finally get this video posted on bluesky. This cartoon illustration should be more clear describing the newly developped transient Pore Analyte Looping (tPAL) platform and the "chop and measure" mode for nanopore protein sequencing. @nature.com www.nature.com/articles/s41...