Panelists: Michael Treadway (Chair), Nadja Ging-Jehli, @rssmith.bsky.social, @cognemo.bsky.social, Carly Lasagna.
#ComputationalPsychiatry #Transdiagnostic @acnporg.bsky.social

Across talks, the emphasis is on mechanism-based phenotyping: parsing heterogeneity within tasks, across task batteries, and over time, rather than relying on static group comparisons.

Highlights include:
• Mechanistic dissociation of maladaptive avoidance and well-being
• Reliable task-based markers linked to HiTOP traits and suicide capability
• Joint brain–behavior modeling of evidence accumulation in psychosis
• Gamified platforms capturing adaptive control and rigidity

We showcase computational approaches—reinforcement learning, diffusion decision models, active inference, and neural modeling—to dissect avoidance, rigidity, learning, and control across anxiety, psychosis, ADHD, depression, and suicide risk.

At #ACNP2026, our panel tackles a core challenge in psychiatry: symptom heterogeneity.
How do we move beyond diagnostic averages to mechanisms that explain why symptoms differ across individuals?

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Sorry: Poster 1.12 by Povilas Karvelis

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