Daniel Aldea
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daldea.bsky.social
Daniel Aldea
@daldea.bsky.social
82 followers 230 following 7 posts
Passionate about development, skin biology, genome regulation, human evolution (#MarseilleMedicalGenetics) #LatinxInSTEM. Road bike. He/him/él.
Posts Replies Media Videos
Reposted by Daniel Aldea
philippebatut.bsky.social
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social

A few highlights below... 🧵👇
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
www.science.org
September 10, 2026 at 10:05 PM
Reposted by Daniel Aldea
matthewcobb.bsky.social
Summary of two terrific new studies of the Denisovans in China. All this work is so exciting - part of one of the greatest scientific breakthroughs of this century. Only discovered in 2010, we now know so much about our cousins who were also us.
Who were the Denisovans? Rich trove of fossils and tools paints new picture
Objects found in a cave in southwestern China suggest that these enigmatic ancient humans were accomplished hunters.
www.nature.com
September 9, 2026 at 4:46 PM
Reposted by Daniel Aldea
sarahmackattack.bsky.social
Call to action for Philly:

I made a printable 8.5x11 flyer for Tuesday's rally. If anyone has the willingness to print and hang this around town, I think that would be great.

Flyer download: drive.google.com/file/d/1qKdB...

RSVP for the rally here: luma.com/1qwnrqz2
A dinosaur on a white background with the text SAve the academy of Natural sciences museum rally Tuesday Sept 8 10am in front of the academy 1900 ben Franklin Parkway. "Tell Drexel University "Keep the museum open!" with the logos for Philly Science Action, Skype a Scientist, and Green Philly
September 5, 2026 at 12:28 AM
Reposted by Daniel Aldea
newscientist.com
The mummies of two people who lived in Chile more than 400 years ago carry DNA from smallpox, providing the first molecular evidence that the virus was brought to the Americas from Europe.
The mummies of two people who lived in Chile more than 400 years ago carry DNA from smallpox, providing the first molecular evidence that the virus was brought to the Americas from Europe
www.newscientist.com
August 3, 2026 at 6:37 PM
Reposted by Daniel Aldea
newscientist.com
From biochemistry in our cells, which dates back to the first single-celled creatures living in the ancient oceans, to our arms and legs, which evolved when amphibians crawled onto land, our bodies are far older and more animal than we like to think. Alice Roberts explains more.
The Forgotten Origins Of Your Human Body
Physically, Homo sapiens isn't that special in the animal world. Bu...
m.youtube.com
June 10, 2026 at 9:04 PM
Reposted by Daniel Aldea
etche.bsky.social
@daldea.bsky.social
February 12, 2026 at 6:20 PM
Reposted by Daniel Aldea
humanists.uk
Happy Darwin Day, everyone! Here's a beautiful quote by the birthday boy himself.

'Endless forms most beautiful and most wonderful have been, and are being, evolved.' Charles Darwin, 'On the Origin of Species'.

Perhaps some of the most important words ever written! #DarwinDay
Thus, from the war of nature, from famine and death, the most exalted object which we are capable of conceiving, namely, the production of higher animals, directly follows. There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.
February 12, 2026 at 8:00 AM
Reposted by Daniel Aldea
erictopol.bsky.social
This week's @nature.com cover highlights a report of A.I.- mediated distortion
When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...
November 2, 2025 at 6:12 PM
Reposted by Daniel Aldea
science.org
Last year, two teams have independently found the long-awaited mutation and discovered a protein that influences hair color in a way never seen before in any animal.

Learn more on #NationalCatDay: https://scim.ag/3LdWP8b
Gene behind orange fur in cats found at last After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do
October 29, 2025 at 4:30 PM
Reposted by Daniel Aldea
mayorlab.bsky.social
Help us to promote this DevBiol course (in Spanish)
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo
Registro "Biología del Desarrollo Sintética: Diseñando la Vida"
Curso Electivo de Verano, dirigido a estudiantes de pregrado Programa: Link Fechas: 5 al 15 de Enero de 2026 Lugar: Santiago de Chile, clases presenciales (Campus Manuel Montt, U. Mayor) Para estudian...
forms.gle
October 26, 2025 at 2:16 PM
Reposted by Daniel Aldea
socdevbio.bsky.social
The next #SDBPostdocSeminar will be held Friday, October 10 at 3 pm Eastern Time with Austin Seroka @austinseroka1.bsky.social from Fred Hutchinson Cancer Center and Heather Dingwall @dingwallaby.bsky.social‬ from @upenn.edu. Register today and join us. bit.ly/4nIlJed
Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series Friday, October 10, 2025, 3:00pm - 4:00 pm Eastern Time Austin Seroka (Fred Hutchinson Cancer Center) Transcription factor code specifies vagal motor innervation of organ targets during development Heather Dingwall (University of Pennsylvania) Mechanisms underlying the evolution of human sweating and fur loss
October 1, 2025 at 9:23 PM
Reposted by Daniel Aldea
roger-mansuy.bsky.social
La plus célèbre des primatologues, Jane Goodall, vient de s'éteindre à 91 ans.

L'occasion de réécouter son interview par @natachatriou.bsky.social en 2022 pour @sciencecqfd.bsky.social

www.radiofrance.fr/francecultur...
Jane Goodall, un singe peut en cacher un autre
Les travaux de la primatologue Jane Goodall ont bouleversé les sciences de la nature, non seulement en ce qui concerne nos connaissances sur les animaux et notre rapport à eux, mais elles ont aussi pe...
www.radiofrance.fr
October 1, 2025 at 6:37 PM
Reposted by Daniel Aldea
lluismontoliu.bsky.social
Hola, en efecto, está explicado mejor en mis diversas intervenciones en medios de comunicación donde lo aclaré, como por ejemplo con @aberron.bsky.social en @eldiario.es
www.eldiario.es/sociedad/son...
Ni son lobos gigantes ni la especie ha sido “desextinguida”: por qué el anuncio de Colossal es pura propaganda
La compañía biotecnológica presume de haber devuelto el lobo gigante a los ecosistemas gracias a la edición genética, pero esa afirmación dista mucho de la realidad
www.eldiario.es
April 11, 2025 at 8:22 AM
Reposted by Daniel Aldea
adamrutherford.bsky.social
The resurrection circus keeps clowning, but make no mistake, Dire wolves remain very extinct.

An angry, sweary piece by a frustrated geneticist.

arutherford.substack.com/p/dire-wolve...
Dire wolves remain very extinct
Despite what you are being fed, de-extinction is a con, full of gloss, bullshit and ghoulish greed.
arutherford.substack.com
April 9, 2025 at 6:22 AM
Reposted by Daniel Aldea
natrevdiseaseprimers.nature.com
Most advanced-stage primary cutaneous melanomas are detected as a large (>5 mm diameter), heterochromic, asymmetric, evolving lesion, a fast-growing amelanotic bump or a heavily pigmented fast-growing lesion. https://www.nature.c...
Clinical and dermoscopic images of primary cutaneous melanomas in patients with darker skin tones.
April 8, 2025 at 9:05 AM
Reposted by Daniel Aldea
marcotrizzino.bsky.social
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
Reposted by Daniel Aldea
arjunraj.bsky.social
Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning!

Documentation here!
docs.nimbusimage.com
NimbusImage
NimbusImage.com
March 17, 2025 at 2:46 PM
Reposted by Daniel Aldea
ferrisjabr.bsky.social
What I Ordered vs What I Got
Photo of a realistic model of a woolly mammoth at the Royal BC Museum in Canada. True to its name, the mammoth is massive, imposing, and hairy, with giant curving tusks. The mammoth stands in front of a painted backdrop of grey cloudy skies and a mostly flat landscape mottled with green. Credit: Thomas Quine Screenshot of a Guardian article. Headline reads: "Scientists aiming to bring back woolly mammoth create wooly mice." The central image features two adorably woolly mice with luscious apricot blonde fur. Subhed: "Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants."
March 4, 2025 at 5:02 PM
daldea.bsky.social
"Casey Brown Lecture Series"...awesome seminar course to honor Casey's memory and given by some of the world's leading experts on human genetics
www.youtube.com/playlist?lis...
Casey Brown Lecture Series - YouTube
www.youtube.com
January 21, 2025 at 9:17 PM
Reposted by Daniel Aldea
ygilad.bsky.social
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful.

It’s available on Amazon: tinyurl.com/mx2hewen
January 17, 2025 at 2:30 PM
Reposted by Daniel Aldea
itaiyanai.bsky.social
Top 4 things to know about doing science:
1. You need to have someone you can talk to
2. One-on-one discussions are the best
3. Think about discussions as improvisations and use the ‘yes, and’ rule
4. Create a safe space so both of you feel open to saying seemingly silly things
January 13, 2025 at 1:52 AM
Reposted by Daniel Aldea
ygilad.bsky.social
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
January 10, 2025 at 3:40 AM
Reposted by Daniel Aldea
evgenykvon.bsky.social
How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n
January 6, 2025 at 2:55 PM
Reposted by Daniel Aldea
etche.bsky.social
We told the whole story to our fellow scientists in under 1,200 words, deposited the data and preprint as #OpenAccess and one of Daniel's confocal microscope images graces the cover of January's upcoming issue of the Journal of Investigative Dermatology.

10/11
Magnification of image shown upthread, overlaid by journal title "JID Journal of INVESTIGATIVE DERMATOLOGY www.jidonline.org"
December 28, 2024 at 2:24 PM
Reposted by Daniel Aldea
etche.bsky.social
To cap a great year for our research group, Drs. Daniel Aldea ( @daldea.bsky.social ), Nicolas Macagno & Elise Marechal drove the investigation of this ongoing question from our team: 🧪

In a group of people born with a #rare large or giant congenital #nevus (CMN, a pigmented birthmark) ...

1/11
Representative image of a large congenital melanocytic nevus stained with antibodies against SPTBN1 (purple) and SOX10 (white), a known melanocyte marker. Epidermal melanocytes (top left corner) and dermal melanocytes (round cell clusters) co-express SPTNB1 and SOX10. Nuclei are counterstained with DAPI (blue), which stains the genomic DNA.
December 28, 2024 at 1:57 PM