Daniel Gerlich
@danielgerlich.bsky.social
Reposted by Daniel Gerlich
New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇
🔗 doi.org/10.64898/2026.05.02.722390 1/6
🔗 doi.org/10.64898/2026.05.02.722390 1/6
doi.org
May 6, 2026 at 7:23 AM
New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇
🔗 doi.org/10.64898/2026.05.02.722390 1/6
🔗 doi.org/10.64898/2026.05.02.722390 1/6
Reposted by Daniel Gerlich
Our Spring PhD call is OPEN! 30+ fully funded positions in diverse life science disciplines. Explore projects in Biochemistry, Biophysics, Structure: www.vbcphd.at
Apply by 9 April
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
Apply by 9 April
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
April 6, 2026 at 11:31 AM
Our Spring PhD call is OPEN! 30+ fully funded positions in diverse life science disciplines. Explore projects in Biochemistry, Biophysics, Structure: www.vbcphd.at
Apply by 9 April
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
Apply by 9 April
Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
Reposted by Daniel Gerlich
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 25, 2026 at 9:45 AM
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Reposted by Daniel Gerlich
Apply to the scientific programmer/bioinformatician position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/scientific-programmer-bioinformatician-gerlich-lab
#research #jobs #europe #biology
#research #jobs #europe #biology
Job Opening: Scientific Programmer / Bioinformatician
www.oeaw.ac.at
January 19, 2026 at 1:50 PM
Apply to the scientific programmer/bioinformatician position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/scientific-programmer-bioinformatician-gerlich-lab
#research #jobs #europe #biology
#research #jobs #europe #biology
Reposted by Daniel Gerlich
We are hiring! Join the Gerlich lab as a scientific programmer/bioinformatician and join an interdisciplinary team studying fundamental mechanisms of chromosome organization, DNA repair, and cell division.
January 19, 2026 at 1:50 PM
We are hiring! Join the Gerlich lab as a scientific programmer/bioinformatician and join an interdisciplinary team studying fundamental mechanisms of chromosome organization, DNA repair, and cell division.
Reposted by Daniel Gerlich
New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Nature Reviews Molecular Cell Biology, Published online: 02 January 2026; doi:10.1038/s41580-025-00933-1Cohesin complexes regulate genome architecture through DNA loop extrusion and sister chromatid cohesion. The Review discusses how these two cohesin activities mediate the organization of replicated chromosomes and their segregation in mitosis and meiosis, DNA break repair, and age-related aneuploidy in oocytes.
bit.ly
January 2, 2026 at 3:13 AM
New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion
Reposted by Daniel Gerlich
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Reposted by Daniel Gerlich
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
An electrostatic repulsion model of centromere organisation
During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...
doi.org
September 3, 2025 at 8:12 AM
1/ New preprint alert!
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis.
🔗 doi.org/10.1101/2025...
Reposted by Daniel Gerlich
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Daniel Gerlich
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
March 28, 2025 at 11:15 AM
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
Reposted by Daniel Gerlich
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
doi.org
February 12, 2025 at 4:00 PM
New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Daniel Gerlich
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop b...
www.biorxiv.org
February 13, 2025 at 1:16 AM
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Reposted by Daniel Gerlich
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
February 12, 2025 at 5:15 PM
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
Reposted by Daniel Gerlich
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...