Ivana Jerkovic
@ivana-jerkovic.bsky.social
Bio-logist, interested in gene regulation, development, 3D chromatin and general life living with a dash of research at College de France.
Pinned
https://biorxiv.org/content/10.110…
Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.110… 1/17
Reposted by Ivana Jerkovic
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Abstract. Polycomb repressive complex 1 (PRC1) forms nuclear condensates that organize target chromatin domains. SUMOylation modulates PRC1 clustering, but
doi.org
September 23, 2026 at 4:41 PM
Thrilled to share my PhD paper showing how SUMO regulates PRC1 clustering and 3D genome organisation independently of H3K27me3! Grateful to @djost-physbiol.bsky.social group and the Fabian Erdel group for this great collaboration. doi.org/10.1093/nar/...
Reposted by Ivana Jerkovic
Happy to be part of this work led by Thierry Cheutin. doi.org/10.1038/s414...
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis - Cell Discovery
Cell Discovery - PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis
doi.org
September 23, 2026 at 4:51 PM
Happy to be part of this work led by Thierry Cheutin. doi.org/10.1038/s414...
If you are in Paris next Friday, 11th of April, come join us for the one-day event on enhancers at Collège de France @collegedefrance.bsky.social. Check out the event poster below showcasing the fantastic speaker list.
April 3, 2025 at 2:04 PM
If you are in Paris next Friday, 11th of April, come join us for the one-day event on enhancers at Collège de France @collegedefrance.bsky.social. Check out the event poster below showcasing the fantastic speaker list.
We seek a bioinformatician to join our group at the College de France, Paris. If you like genomics, 3D genome organization, gene regulation, and development check out the offer and get in touch!
January 31, 2025 at 11:09 AM
We seek a bioinformatician to join our group at the College de France, Paris. If you like genomics, 3D genome organization, gene regulation, and development check out the offer and get in touch!
Reposted by Ivana Jerkovic
Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids
Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-...
www.biorxiv.org
December 24, 2024 at 3:47 PM
Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
What an amazing lab outing it was yesterday! Visiting both the public and non-public collections of National Museum of Natural History all rounded with the best guide.
December 12, 2024 at 5:21 PM
What an amazing lab outing it was yesterday! Visiting both the public and non-public collections of National Museum of Natural History all rounded with the best guide.
Reposted by Ivana Jerkovic
Excited to share my new paper implicating the 3D genome in epigenetic inheritance. We show that chromatin contacts are able to trigger epimutation in Drosophila. I'm very thankful for the support of Giacomo Cavalli, @psarkies.bsky.social and to all others involved!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila
In some cases, non-genetic information can be inherited across generations. Fitz-James et al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They show that physical contact between regions of DNA within the cell is able to trigger the histone modification H3K27me3 to become heritable.
www.cell.com
December 11, 2024 at 4:16 PM
Excited to share my new paper implicating the 3D genome in epigenetic inheritance. We show that chromatin contacts are able to trigger epimutation in Drosophila. I'm very thankful for the support of Giacomo Cavalli, @psarkies.bsky.social and to all others involved!
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
This is what I experienced since I started doing science. I always felt I'm better at developing ideas/discussing novelties/troubleshooting when I have a friend/colleague (ideally in the same person) to bounce ideas off. I think we'd all benefit if academia starts encouraging the concept of co-PIs.
The good idea comes when one person feels comfortable enough to say something that might make them look stupid and their friend is open enough to recognize its potential.
December 8, 2024 at 1:15 PM
This is what I experienced since I started doing science. I always felt I'm better at developing ideas/discussing novelties/troubleshooting when I have a friend/colleague (ideally in the same person) to bounce ideas off. I think we'd all benefit if academia starts encouraging the concept of co-PIs.
Reposted by Ivana Jerkovic
Join us in Banff for the Keystone Interplay of Chromatin Architecture and Transcriptional Regulation meeting next spring (joint with Epigenetics in Development and Disease): www.keystonesymposia.org/conferences/... Short talk abstract coming up - Jan 9
December 6, 2024 at 9:11 AM
Join us in Banff for the Keystone Interplay of Chromatin Architecture and Transcriptional Regulation meeting next spring (joint with Epigenetics in Development and Disease): www.keystonesymposia.org/conferences/... Short talk abstract coming up - Jan 9
Reposted by Ivana Jerkovic
We are advertising for a project looking at epigenetic inheritance in Drosophila at the Department of Biology, University of Oxford @oxfordbiology.bsky.social Please get in touch if you are interested! Only 1 month left to be considered for funding.
www.findaphd.com/phds/project...
How is epigenetic information inherited across generations in insects? at University of Oxford on FindAPhD.com
PhD Project - How is epigenetic information inherited across generations in insects? at University of Oxford, listed on FindAPhD.com
www.findaphd.com
December 2, 2024 at 1:10 PM
We are advertising for a project looking at epigenetic inheritance in Drosophila at the Department of Biology, University of Oxford @oxfordbiology.bsky.social Please get in touch if you are interested! Only 1 month left to be considered for funding.
www.findaphd.com/phds/project...
Reposted by Ivana Jerkovic
Ever wondered how bats develop wings from their hands? 🦇✨
Check out our new preprint and the thread below! 🤓
👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂
www.biorxiv.org/content/10.1...
Check out our new preprint and the thread below! 🤓
👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂
www.biorxiv.org/content/10.1...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene program in bat wing development
Bats are the only mammals capable of self-powered flight, an evolutionary innovation based on the transformation of forelimbs into wings. The bat wing is characterized by an extreme elongation of the ...
www.biorxiv.org
December 1, 2024 at 10:11 AM
Ever wondered how bats develop wings from their hands? 🦇✨
Check out our new preprint and the thread below! 🤓
👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂
www.biorxiv.org/content/10.1...
Check out our new preprint and the thread below! 🤓
👏Big applause to our amazing first authors Magdalena Schindler and Christian Feregrino and thanks to all our co-authors for their help! 🥂
www.biorxiv.org/content/10.1...
Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.110… 1/17
https://biorxiv.org/content/10.110…
December 1, 2024 at 2:55 PM
Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.110… 1/17
Reposted by Ivana Jerkovic
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology
Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...
www.nature.com
November 28, 2024 at 12:48 PM
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...