Jeroen Pasterkamp
@jeroenpasterkamp.bsky.social
Head Department of Translational Neuroscience, Chair UMC Utrecht Brain Center, neuroscientist, brain circuit development & disease, 🏊♂️, beach🏐 and 🚴♂️ www.jeroenpasterkamplab.com
MEETING ALERT! October 6-8 2027 we are organizing the next edition of the AXON meeting, AXON2027! Location ssRotterdam 🛥️! All you want to know about axons, synapses, circuitry, development, plasticity, regeneration in different species, and much more! Registration opens early 2027!
September 14, 2026 at 4:46 PM
MEETING ALERT! October 6-8 2027 we are organizing the next edition of the AXON meeting, AXON2027! Location ssRotterdam 🛥️! All you want to know about axons, synapses, circuitry, development, plasticity, regeneration in different species, and much more! Registration opens early 2027!
September 6, 2026 the next edition of the Amsterdam City Swim will be held to raise awareness and research funding for ALS. I will join and swim 700 m and 2.2 km swims in the canals of Amsterdam with Daan and Ella Pasterkamp. If you want to support me: www.amsterdamcityswim.nl/fundraisers/...
August 21, 2026 at 6:23 PM
September 6, 2026 the next edition of the Amsterdam City Swim will be held to raise awareness and research funding for ALS. I will join and swim 700 m and 2.2 km swims in the canals of Amsterdam with Daan and Ella Pasterkamp. If you want to support me: www.amsterdamcityswim.nl/fundraisers/...
Looking forward to the iMND meeting at the ssRotterdam 🛳️ September 30 2026! Everything you want to know about stem cell modelling for neuromuscular disease! If you want to join send us a DM.
August 8, 2026 at 8:02 AM
Looking forward to the iMND meeting at the ssRotterdam 🛳️ September 30 2026! Everything you want to know about stem cell modelling for neuromuscular disease! If you want to join send us a DM.
In a new study in @cp-neuron.bksy.social we demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental and adult morphologies, as well as responses to axon degeneration. www.cell.com/neuron/fullt...
Single-neuron resolution mapping of dopaminergic connectivity across development, adulthood, and degeneration
Using a novel intersectional genetic strategy for sparse neuronal labeling, Grossouw,
Heijmink, et al. reconstruct individual midbrain dopamine neurons throughout development,
adulthood, and degenerat...
www.cell.com
August 8, 2026 at 7:44 AM
In a new study in @cp-neuron.bksy.social we demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental and adult morphologies, as well as responses to axon degeneration. www.cell.com/neuron/fullt...
Reposted by Jeroen Pasterkamp
Researchers (led by @jeroenpasterkamp.bsky.social) demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental & adult morphologies, as well as responses to axon degeneration
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
August 1, 2026 at 12:11 PM
Researchers (led by @jeroenpasterkamp.bsky.social) demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental & adult morphologies, as well as responses to axon degeneration
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Jeroen Pasterkamp
A catch-up on recent group publications!
First, a perspective on the state of the field on study of microglial dysfunction in C9orf72 #ALS and #FTD in iPSCs from @bvahsen.bsky.social together with @jeroenpasterkamp.bsky.social.
journals.lww.com/nrronline/ci...
First, a perspective on the state of the field on study of microglial dysfunction in C9orf72 #ALS and #FTD in iPSCs from @bvahsen.bsky.social together with @jeroenpasterkamp.bsky.social.
journals.lww.com/nrronline/ci...
journals.lww.com
April 28, 2026 at 11:13 AM
A catch-up on recent group publications!
First, a perspective on the state of the field on study of microglial dysfunction in C9orf72 #ALS and #FTD in iPSCs from @bvahsen.bsky.social together with @jeroenpasterkamp.bsky.social.
journals.lww.com/nrronline/ci...
First, a perspective on the state of the field on study of microglial dysfunction in C9orf72 #ALS and #FTD in iPSCs from @bvahsen.bsky.social together with @jeroenpasterkamp.bsky.social.
journals.lww.com/nrronline/ci...
Reposted by Jeroen Pasterkamp
📃Presentation of EP briefing by neuroscientists @ellyhol.bsky.social & @jeroenpasterkamp.bsky.social
Strengthening Brain Health: Policy Recommendations to Tackle the Rising Burden of Neurological Diseases
www.europarl.europa.eu/cmsdata/3028...
Strengthening Brain Health: Policy Recommendations to Tackle the Rising Burden of Neurological Diseases
www.europarl.europa.eu/cmsdata/3028...
February 24, 2026 at 2:11 PM
📃Presentation of EP briefing by neuroscientists @ellyhol.bsky.social & @jeroenpasterkamp.bsky.social
Strengthening Brain Health: Policy Recommendations to Tackle the Rising Burden of Neurological Diseases
www.europarl.europa.eu/cmsdata/3028...
Strengthening Brain Health: Policy Recommendations to Tackle the Rising Burden of Neurological Diseases
www.europarl.europa.eu/cmsdata/3028...
Exciting opportunity to learn about #humanbrainmodels and #singlecelltechnology! July 13-17 2026 we for the first time will offer the Utrecht Summer School titled "Advanced human brain models in the single-cell era" for master and PhD students. Apply now: utrechtsummerschool.nl/courses/life...
LinkedIn
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lnkd.in
December 13, 2025 at 9:37 AM
Exciting opportunity to learn about #humanbrainmodels and #singlecelltechnology! July 13-17 2026 we for the first time will offer the Utrecht Summer School titled "Advanced human brain models in the single-cell era" for master and PhD students. Apply now: utrechtsummerschool.nl/courses/life...
Great thesis defense by Astrid van der Geest today on unveiling early pathologies in #ALS using #organoids. @umcutrecht.bsky.social
November 5, 2025 at 7:32 AM
Great thesis defense by Astrid van der Geest today on unveiling early pathologies in #ALS using #organoids. @umcutrecht.bsky.social
#NHDN25 was a great meeting with many excellent talks and posters!
Professor @jeroenpasterkamp.bsky.social just presented his work at #NHND25 on modelling neurodegenerative diseases in a dish, showing new avenues in using organoids models in C9-ALS 🧫
October 11, 2025 at 3:56 PM
#NHDN25 was a great meeting with many excellent talks and posters!
Presentations at the annual meeting of our NWO Gravitation Consortium BRAINSCAPES with Nik Heijmink presenting our recent genetic sparse labeling approach in the dopamine midbrain and Pavol ZELINA sharing insights into HT screening for neurodegenerative disease using human in vitro models.
October 1, 2025 at 10:29 AM
Presentations at the annual meeting of our NWO Gravitation Consortium BRAINSCAPES with Nik Heijmink presenting our recent genetic sparse labeling approach in the dopamine midbrain and Pavol ZELINA sharing insights into HT screening for neurodegenerative disease using human in vitro models.
In our new study in BRAIN, we use a brain organoid model in which microglia innately develop to further dissect the mechanisms that cause changes in microglia in C9ORF72-ALS and show that PU.1 can help to reverse these pathogenic phenotypes. #GoALS
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids
Accumulating evidence implicates non-neuronal cells in ALS pathogenesis. Using patient-derived cerebral organoids, Ljubikj et al. reveal reduced microglial
academic.oup.com
September 13, 2025 at 9:24 PM
In our new study in BRAIN, we use a brain organoid model in which microglia innately develop to further dissect the mechanisms that cause changes in microglia in C9ORF72-ALS and show that PU.1 can help to reverse these pathogenic phenotypes. #GoALS
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
The Amsterdam City Swim was again a very special event that raised 1.7 million Euro for research into ALS last Sunday. I had the privilege to join with both both my son and daughter, which made it even more special. Thanks to everyone for sponsoring us. Looking forward to ACS 2026!
September 10, 2025 at 10:21 PM
The Amsterdam City Swim was again a very special event that raised 1.7 million Euro for research into ALS last Sunday. I had the privilege to join with both both my son and daughter, which made it even more special. Thanks to everyone for sponsoring us. Looking forward to ACS 2026!
Thanks to the @neurochemistry.org (ISN) for allowing me to organize a symposium on ‘Molecular mechanisms of motor neuron disease’ at the 2025 ISN-ASN meeting in NYC. Great talks by Christine Vande Velde, Stefania Corti and Sami Barmada.
August 20, 2025 at 1:50 PM
Thanks to the @neurochemistry.org (ISN) for allowing me to organize a symposium on ‘Molecular mechanisms of motor neuron disease’ at the 2025 ISN-ASN meeting in NYC. Great talks by Christine Vande Velde, Stefania Corti and Sami Barmada.
Check out this paper by Werner Dykstra in which we study the effects of GFAP mutations on brain organoid development. doi.org/10.1002/glia...
Mutations in GFAP Alter Early Lineage Commitment of Organoids
Mutations in GFAP alter lineage commitment of organoids. The severity of this commitment defect is dependent on the method of embryoid body formation. GFAP is expressed in iPSCs and during early st...
doi.org
July 30, 2025 at 2:00 PM
Check out this paper by Werner Dykstra in which we study the effects of GFAP mutations on brain organoid development. doi.org/10.1002/glia...
OUT NOW!! We developed a brain organoid slice protocol to study and manipulate human microglia in a 3D brain-like environment. Great work by Marta Cañizares Luna, Mayte Mars and Channa Jakobs. www.sciencedirect.com/science/arti...
Protocol for generating and using human iPSC-derived microglia-containing air-liquid-interface cortical organoid cultures
Here, we present a protocol for generating long-term microglia-containing air-liquid-interface cortical organoid (MG-ALI-CO) cultures. This approach m…
www.sciencedirect.com
July 4, 2025 at 12:18 PM
OUT NOW!! We developed a brain organoid slice protocol to study and manipulate human microglia in a 3D brain-like environment. Great work by Marta Cañizares Luna, Mayte Mars and Channa Jakobs. www.sciencedirect.com/science/arti...
Extremely proud of Özge Düdükcü, who defended her thesis on GABAergic neuron diversity and development on May 1st in Utrecht!
June 1, 2025 at 9:32 AM
Extremely proud of Özge Düdükcü, who defended her thesis on GABAergic neuron diversity and development on May 1st in Utrecht!
This week we organized the 2nd edition of the DDSSCC (Development of the dopaminergic system - from stem cells to circuits) meeting in Crete! Great science and a fantastic atmosphere. Excellent talk by Eljo van Battum from the lab and a poster prize for Oxana Garritsen! See you all for DDSSCC 2028!
May 28, 2025 at 5:20 PM
This week we organized the 2nd edition of the DDSSCC (Development of the dopaminergic system - from stem cells to circuits) meeting in Crete! Great science and a fantastic atmosphere. Excellent talk by Eljo van Battum from the lab and a poster prize for Oxana Garritsen! See you all for DDSSCC 2028!
Out now: Our meeting report of the 2024 European Society of Toxicologic Pathology (ESTP) meeting session 'Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery'. doi.org/10.1177/0192...
Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery - Laura Fusaro, Dinesh S. Bangari, R. Jeroen Pasterkamp, Javier Fernández-Ruiz, Sameh A. Youssef, Alok ...
The fourth session of the 2024 European Society of Toxicologic Pathology (ESTP) Congress brought together lectures focused on the use of in vitro and in vivo mo...
doi.org
May 16, 2025 at 10:17 AM
Out now: Our meeting report of the 2024 European Society of Toxicologic Pathology (ESTP) meeting session 'Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery'. doi.org/10.1177/0192...
Check out our review on the role of guidance proteins in neuron migration by Eljo van Battum and Marleen van den Munkhof. www.sciencedirect.com/science/arti...
Novel insights into the regulation of neuron migration by axon guidance proteins
Neural circuit development requires precisely coordinated guidance of migrating neurons to their targets within the nervous system. A diverse array of…
www.sciencedirect.com
April 4, 2025 at 4:27 PM
Check out our review on the role of guidance proteins in neuron migration by Eljo van Battum and Marleen van den Munkhof. www.sciencedirect.com/science/arti...
Talking at the 1st edition of New Horizons in Neurodegeneration, a two-day conference in Leuven, Belgium: www.vibconferences.be/events/new-h.... This event will bring together leading experts to explore the complexities of Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
New Horizons in Neurodegeneration
9-10 October 2025, Leuven, Belgium Organized in partnership with Cell Press
www.vibconferences.be
April 2, 2025 at 7:46 AM
Talking at the 1st edition of New Horizons in Neurodegeneration, a two-day conference in Leuven, Belgium: www.vibconferences.be/events/new-h.... This event will bring together leading experts to explore the complexities of Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
Had the pleasure of visiting the Institute of Psychiatry, Psychology & Neuroscience at King’s College London yesterday! Big thanks to Jemeen Sreedharan.
April 2, 2025 at 7:41 AM
Had the pleasure of visiting the Institute of Psychiatry, Psychology & Neuroscience at King’s College London yesterday! Big thanks to Jemeen Sreedharan.
Reposted by Jeroen Pasterkamp
Op 25-4 presenteren we dit boek. In het Flevoparkbad in Amsterdam. Met Femke Heemskerk; @jeroenpasterkamp.bsky.social de zwemmende burgemeester van Heiloo @spinvis.bsky.social en anderen. Wees welkom!
March 18, 2025 at 6:31 PM
Op 25-4 presenteren we dit boek. In het Flevoparkbad in Amsterdam. Met Femke Heemskerk; @jeroenpasterkamp.bsky.social de zwemmende burgemeester van Heiloo @spinvis.bsky.social en anderen. Wees welkom!
Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social
March 13, 2025 at 3:51 PM
Registration for the 10th edition of our Summerschool on 'Neural circuit development and plasticity' is open! July 7-11 in Utrecht for MSc and PhD students, and others who are interested. Spread the news! @umcutrecht.bsky.social @utrechtuniversity.bsky.social
Reposted by Jeroen Pasterkamp
Echt heel cool!
Bij de limited edition van mijn nieuwe boek 📘: De mooiste 50 meter buitenbaden van Nederland 🇳🇱 sealen in oplage van 2️⃣0️⃣0️⃣ de Spinvis-singel Ik wil alleen maar zwemmen op vinyl bij.
Alle info via buitenbaden.com kan je eventueel een exemplaar reserveren.
@dolfjansen.bsky.social
March 6, 2025 at 11:02 AM
Echt heel cool!
Bij de limited edition van mijn nieuwe boek 📘: De mooiste 50 meter buitenbaden van Nederland 🇳🇱 sealen in oplage van 2️⃣0️⃣0️⃣ de Spinvis-singel Ik wil alleen maar zwemmen op vinyl bij.
Alle info via buitenbaden.com kan je eventueel een exemplaar reserveren.
@dolfjansen.bsky.social