Translating inputs from tactile sensors into pulses that organoids could sense helped the cells recognize Braille letters, which could advance biohybrid computing.

Epithelial surfaces are the primary sites of lytic herpes simplex virus 1 (HSV-1) infection following initial exposure or reactivation from latency. To model this complex environment, we used human ha...

Translating inputs from tactile sensors into pulses that organoids could sense helped the cells recognize Braille letters, which could advance biohybrid computing.

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and is one of the most aggressive and deadly forms of cancer.

In recent years, demand for human-based in vitro models has grown substantially. In this regard, human secondary lymphoid organ (SLO)-derived ex vivo immune organoids are gaining recognition, as they...

Scientists discovered that human brain organoids, which are small neural clusters derived from stem cells, could identify the Braille alphabet with a high degree of accuracy.

Human tissue models are rewriting preclinical science. Tavakol et al. examine how converging cell biology and bioengineering can close translational gaps, overcome reproducibility and regulatory hurdles, and, with synthetic biology, multi-omics, and AI, turn organoids and organs-on-a-chip into foundational platforms for personalized medicine, drug discovery, and regenerative therapies.

hPSC-derived distal bud tip organoids that resemble fetal alveolar progenitors are developed and used to show that air-liquid interface culture and cyclic stretch enhance alveolar epithelial maturatio...

Researchers at the Max Delbrück Center and University Medical Center Hamburg-Eppendorf have traced in skin organoids, how herpes simplex virus 1 infection progresses among neighboring skin cells, deepening our understanding. The work was published in Science Advances. Most people think of herpes simplex virus 1 (HSV-1) as a mere cosmetic problem: The virus can cause outbreaks of cold sores on the lips or face, which usually heal on their own within two weeks. But HSV-1 infection can be more sinister. The virus infects sensory nerve cells in the face, where it usually remains dormant. In rare cases, it travels to the central nervous system and causes life-threatening brain inflammation. HSV-1 is also being investigated for potentially playing a role in Alzheimer's disease - its lifelong persistence in our nervous system may eventually damage nerve cells. Dr. Emanuel Wyler, a scientist in the RNA Biology and Posttranscriptional Regulation lab at the Max Delbrück Center, has had a longstanding interest in understanding how the virus causes disease. Now he and collaborators at University Medical Center Hamburg-Eppendorf (UKE) have traced step by step how HSV-1 infects the multiple layers of skin cells. Using human hair-bearing skin organoids as a model, the researchers mapped...