Hi there
Thanks for noticing.
Here you go:

link.springer.com/article/10.1...

www.jcvaonline.com/article/S105...

Problem is twofold: LoA are around +/- 10%. ScvO2 of 55 then is not helpful. Trends do not point in the same direction. We showed this here: pubmed.ncbi.nlm.nih.gov/36511508/

And other studies:

doi.org/10.1007/s00134…

doi.org/10.1053/j.jvca���

Bottom line: when it counts, it is not helpful.

IAP measurement does not require seadtion or neuromuscular blockade. That is a myth that needs to disappear. Measuring pressure is simple and accurate; a measurement of 18 is what it is. Sedation and paralytics can lower that number, but that is a therapy for IAP rather than enabling a measurement.

My issue with ScvO2 is, that it can be high while true mixed venous (SvO2) is low. It is a bad surrogate for SvO2.
So when in doubt, float a PAC and know for sure.

My question is, does it truly matter? If there’s a strong signal, shouldn’t I be able to detect it using either method (and vice versa)? And if the signal is borderline, shouldn’t I arrive at the same interpretation if my application and understanding of the statistics used are accurate?

@gurujosh.bsky.social presents the results of the MSSA domain of the SNAP 🫰 trial at #ESCMID2025

fluclox caused more acute kidney injury than cefazolin; early mortality favored cefazolin

Absolutely Herculean effort by the entire global trial team and practice changing data #teamcefazolin

I don’t think that offering specific therapies out of the context of goals of care is helpful and may negatively impact the discussion and patient trajectory.

I think we want to define where a patient wants to be in 1/3/6/12 months and with what level of quality of life. We as a team can then offer specific therapies (i.e. Trach/PEG but also other options such as mech. assist devices), if and only if these therapies align with the defined goals of care.

Recently listened to this:

soundphysicians.com/podcast-epis...

Has some good pearls and pitfalls and some resources in the shownotes.

📌

Do you/does anyone know if there are data repositories with patient data, timepoints and vanco levels as well as reference clearence (maybe from observational studies)?
We could then use that to 1) validate and 2) develop new models.

#emimcc
I plan to do a thread on the paper/topic soon. This project has kept me busy over the last two years and it has been a pleasure working alongside an awesome steering committee and Delphi panel. 🙏