Kevin Kelley
kevinkelley.bsky.social
Kevin Kelley
@kevinkelley.bsky.social
Assistant Professor Stanford. Neuroscientist and psychiatrist. Cellular and molecular mechanisms of human brain development and disease.
Reposted by Kevin Kelley
The experimental strategy overcomes hurdles that have long stymied researchers studying neuropsychiatric illness in lab-grown brain tissue

go.nature.com/4ixYQe1
Human brain cells transplanted into mice in ‘most extensive’ integration ever
Lab-grown organoids wire into mice missing a key part of their brain, offering a new way to test drugs for developmental conditions.
go.nature.com
September 16, 2026 at 3:15 PM
Reposted by Kevin Kelley
Replacing the mouse cortex with human-derived brain organoids could offer a new way to study how circuits form and conditions such as autism.

By @briannaabbott.bsky.social

www.thetransmitter.org/spectrum/hum...
Human brain organoids flourish in emptied mouse cortex
The chimeric mice could help untangle the biology of human brain development or conditions such as autism.
www.thetransmitter.org
September 16, 2026 at 3:12 PM
Reposted by Kevin Kelley
Scientists replaced half a mouse’s brain with a few million human neurons. It could become new way to study dementia and other brain disorders. Gift link: nyti.ms/4xqUcCk
Scientists Fuse Human Neurons Into the Brains of Mice (Gift Article)
The studies may help reveal the causes of brain disease in people and point the way to treatments. But researchers already are calling for new ethical guidelines.
nyti.ms
September 16, 2026 at 3:07 PM
1/ I have long dreamed of systems that could causally model human neurobiology across scales, from molecular to behavioral.

In @nature.com, delighted to share our efforts at creating xenocortical mice where human organoids grow to occupy most of mouse cortex.
September 16, 2026 at 5:52 PM
Thrilled to join the NGL program! Grateful for the opportunity to engage with NGL peers and the @alleninstitute.bsky.social scientists behind the incredible datasets that support so much of my work.
December 19, 2024 at 5:20 PM
Great to see our paper online!

Amazing collaboration with Neal over the years, with lots of help from others in the Pasca group.
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
December 6, 2024 at 9:28 PM