Justin Mabin
@mabinjw.bsky.social
Husband, Dad, and PhD.
RNA Biochemist/Bioinformatician in the Hogg lab at the NIH NHLBI, studying the effects of spliceosome dysfunction on the transcriptome.
RNA Biochemist/Bioinformatician in the Hogg lab at the NIH NHLBI, studying the effects of spliceosome dysfunction on the transcriptome.
Reposted by Justin Mabin
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome
By Soles et al. and Yongsheng Shi
➡️ https://ow.ly/bXG150ZachI
UC Irvine UC Irvine School of Medicine
#RNAprocessing #splicing #mRNA #transcription
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome
By Soles et al. and Yongsheng Shi
➡️ https://ow.ly/bXG150ZachI
UC Irvine UC Irvine School of Medicine
#RNAprocessing #splicing #mRNA #transcription
June 25, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome
By Soles et al. and Yongsheng Shi
➡️ https://ow.ly/bXG150ZachI
UC Irvine UC Irvine School of Medicine
#RNAprocessing #splicing #mRNA #transcription
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome
By Soles et al. and Yongsheng Shi
➡️ https://ow.ly/bXG150ZachI
UC Irvine UC Irvine School of Medicine
#RNAprocessing #splicing #mRNA #transcription
Reposted by Justin Mabin
Looking forward to sharing this story in person at #RNASociety on Friday!
I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.
I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.
🚨The lab's first research paper is In Press at JBC!
Congrats Liza and Magda!!
Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization - Journal of Biological Chemistry www.jbc.org/article/S002...
Congrats Liza and Magda!!
Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization - Journal of Biological Chemistry www.jbc.org/article/S002...
Pontocerebellar Hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization
The Target of EGR1 (TOE1) gene encodes the TOE1 deadenylase, which is essential for
the maturation of Pol-II transcribed snRNAs in humans. Over a dozen missense mutations
in the TOE1 gene have been li...
www.jbc.org
May 25, 2026 at 1:48 PM
Looking forward to sharing this story in person at #RNASociety on Friday!
I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.
I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.
Excited to be part of this collaborative work on telomere biology in pluripotent cells. We found that nonsense-mediated mRNA decay (NMD) becomes essential for cell survival in the absence of TRF2, by preventing production of a dominant-negative TRF1 isoform.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells - Nature Cell Biology
Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at ...
www.nature.com
March 27, 2026 at 1:40 PM
Excited to be part of this collaborative work on telomere biology in pluripotent cells. We found that nonsense-mediated mRNA decay (NMD) becomes essential for cell survival in the absence of TRF2, by preventing production of a dominant-negative TRF1 isoform.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Justin Mabin
Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1
March 15, 2025 at 3:16 AM
Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1
Reposted by Justin Mabin
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.