Genes & Development
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genesdev.bsky.social
Genes & Development
@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
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🚨 NEW ISSUE ALERT!!! 🚨

New Research articles online now at Genes & Development!

Also in this issue, a Perspective on the state of pediatric sarcoma research, a Review on RNAs in hybrid compatibility, and more...

Click here to learn more:
➡️ https://genesdev.cshlp.org/content/40/17-18.toc
We are saddened by the loss of G&D's long-time Editor, Terri Grodzicker.
When Terri stepped down as Editor in 2022, friends and colleagues wrote about her contributions to the research community. We are re-visiting these pieces, and thinking of her.
➡️ https://genesdev.cshlp.org/content/37/1-2.toc
September 18, 2026 at 2:01 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture
By Mendoza-Figueroa et al. and Kathy Fange Liu
➡️ https://ow.ly/ty5R50ZOM7h

@kathyliulab.bsky.social University of Pennsylvania Penn Medicine
#RNA #nucleus #genome
September 17, 2026 at 3:20 PM
RESEARCH PAPER: A conserved Notch–Meis1–Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells
By Sur, Segal et al., and Jeffrey Farrell
➡️ https://genesdev.cshlp.org/content/40/17-18/1553.abstract

Jeff Farrell Abhinav Sur
#intestine #pHsensing #Notch
September 16, 2026 at 6:00 PM
RESEARCH PAPER: Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity
By Dutta et al., Gilberto Garcia and Ryo Higuchi-Sanabria
➡️ https://genesdev.cshlp.org/content/40/17-18/1523.full

@usc.edu @uscleonarddavis.bsky.social
September 15, 2026 at 6:00 PM
OUTLOOK: An antisense antidote to oncogenic poison exons
By René Arvola and Guramrit Singh
➡️ https://genesdev.cshlp.org/content/40/17-18/1367.full

Also read:
➡️ https://genesdev.cshlp.org/content/40/17-18/1508.full

Guramrit Singh
#RNA #splicing #cancer
September 15, 2026 at 3:00 PM
RESEARCH PAPER: Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction
By Islam et al. and Mohammad Alinoor Rahman
➡️ https://genesdev.cshlp.org/content/40/17-18/1508.full

#RNA #splicing #cancer
September 14, 2026 at 6:01 PM
ON THE COVER: Using CRASP-seq to uncover key regulators of UPR.
Artwork by Kate Zvorykina (Ella Maru Studio)

Learn more in this study by Kim et al., and Thomas Gonatopoulos-Pournatzis:
➡️ https://genesdev.cshlp.org/content/40/17-18/1448.full
September 14, 2026 at 3:04 PM
PERSPECTIVE: Pediatric sarcomas: challenges and opportunities
By Gao et al., and Lillian Guenther
➡️ https://genesdev.cshlp.org/content/40/17-18/1370.full

#pediatriccancer #pediatricsarcoma #cancertherapeutics
September 11, 2026 at 6:00 PM
Read the G&D Perspective:
➡️ genesdev.cshlp.org/content/40/1...
Hosted at CSHL's Banbury Center, a group of scientists, clinicians, patient advocates, and philanthropists discussed an action plan for battling pediatric sarcomas. Their hard work was published in Genes & Development. Read more: https://www.cshl.edu/child-cancer-groups-call-for-concerted-action/.
September 11, 2026 at 12:50 PM
RESEARCH PAPER: Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance
By Chen et al., and Carolyn Phillips
➡️ https://genesdev.cshlp.org/content/40/17-18/1484.abstract

Carolyn Phillips Shihui Chen The University of Southern California
September 10, 2026 at 6:00 PM
RESEARCH PAPER: MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice
By Lukaszewicz et al., Scott Keeney, and Maria Jasin
➡️ https://genesdev.cshlp.org/content/40/17-18/1466.full

Memorial Sloan Kettering Cancer Center University of Michigan
#DNArepair #mutagenesis #genome
September 9, 2026 at 6:00 PM
RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1
By Kim et al., and Thomas Gonatopoulos-Pournatzis
➡️ https://genesdev.cshlp.org/content/40/17-18/1448.full

#RNA #splicing #stress #UPR
September 8, 2026 at 6:00 PM
RESEARCH PAPER: Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes
By Gomez-Gil et al., and Snezhana Oliferenko
➡️ https://genesdev.cshlp.org/content/40/17-18/1429.full

Snezhka Oliferenko
The Francis Crick Institute King's Faculty of Life Sciences & Medicine
September 7, 2026 at 6:00 PM
REVIEW: Maternal small RNAs as gatekeepers of hybrid compatibility in plants and animals
By Katarzyna Dziasek and Claudia Köhler
➡️ https://genesdev.cshlp.org/content/40/17-18/1382.full

Claudia Köhler
Max Planck Institute of Molecular Plant Physiology 🌱🧪
September 4, 2026 at 6:00 PM
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://genesdev.cshlp.org/content/40/17-18/1408.abstract

Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
September 3, 2026 at 6:00 PM
RESEARCH PAPER: Machine learning analysis of the human initiator region reveals key features of different types of core promoters
By Rhyne-Carrigg et al., and James T. Kadonaga
➡️ https://genesdev.cshlp.org/content/40/17-18/1397.full

UC San Diego
#transcription #machinelearning
September 2, 2026 at 6:00 PM
🚨 NEW ISSUE ALERT!!! 🚨

New Research articles online now at Genes & Development!

Also in this issue, a Perspective on the state of pediatric sarcoma research, a Review on RNAs in hybrid compatibility, and more...

Click here to learn more:
➡️ https://genesdev.cshlp.org/content/40/17-18.toc
September 1, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: A conserved Notch–Meis1–Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells
By Sur, Segal et al., and Jeffrey Farrell
➡️ https://ow.ly/mMhL50ZFnYi

Jeff Farrell Abhinav Sur
#intestine #pHsensing #Notch #cellspecification
August 31, 2026 at 3:00 PM
🌟 G&D SPOTLIGHT 🌟

G&D is pleased to present a collection of recent articles that offer new insights into the processes shaping gene expression and cell function.

Learn more about chromatin regulation, RNA processing, and more here:
➡️ https://genesdev.cshlp.org/site/misc/molregulation.xhtml
August 28, 2026 at 6:01 PM
🆕 ADVANCE ONLINE 🆕

REVIEW: Maternal small RNAs as gatekeepers of hybrid compatibility in plants and animals
By Katarzyna Dziasek and Claudia Köhler
➡️ https://ow.ly/Gtmx50ZFm9m

Claudia Köhler Max Planck Institute of Molecular Plant Physiology 🌱🧪
#smallRNA #inheritance #hybridization #evolution
August 28, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity
By Dutta et al., Gilberto Garcia and Ryo Higuchi-Sanabria
➡️ https://ow.ly/vqZF50ZFlAO

@usc.edu @uscleonarddavis.bsky.social
August 27, 2026 at 6:00 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes
By Gomez-Gil et al., and Snezhana Oliferenko
➡️ https://ow.ly/VfIS50ZFkK4

Snezhka Oliferenko The Francis Crick Institute King's Faculty of Life Sciences & Medicine
August 27, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1
By Kim et al., and Thomas Gonatopoulos-Pournatzis
➡️ https://ow.ly/B7BF50ZFl79

#RNA #splicing #stress #UPR
August 26, 2026 at 6:01 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://ow.ly/ljPI50ZFk2g

Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
August 26, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction
By Islam et al. and Mohammad Alinoor Rahman
➡️ https://ow.ly/ukZ650ZFjFr

#RNA #splicing #cancer
August 25, 2026 at 4:48 PM