New Article: "The SCHENGEN pathway regulates lignin barrier formation via the receptor-like cytoplasmic kinase BIK1 in plant immunity" rdcu.be/GkvmE7ArjPfa
The SCHENGEN pathway, known for forming a diffusion barrier in roots, also functions in plant immunity. #PlantScience
The SCHENGEN pathway, known for forming a diffusion barrier in roots, also functions in plant immunity. #PlantScience
November 2, 2026 at 8:24 PM
New Article: "The SCHENGEN pathway regulates lignin barrier formation via the receptor-like cytoplasmic kinase BIK1 in plant immunity" rdcu.be/GkvmE7ArjPfa
The SCHENGEN pathway, known for forming a diffusion barrier in roots, also functions in plant immunity. #PlantScience
The SCHENGEN pathway, known for forming a diffusion barrier in roots, also functions in plant immunity. #PlantScience
For readers interested in strategies in the design of kinase modulators, here's a comprehensive recent review www.nature.com/articles/s41...
rdcu.be/7nDDFUkn4W9a
rdcu.be/7nDDFUkn4W9a
Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies - Nature Reviews Drug Discovery
Kinases represent one of the largest superfamilies of drug targets, but many members have remained notoriously challenging to drug by traditional small-molecule approaches. This Review assesses approa...
www.nature.com
November 4, 2026 at 3:19 PM
For readers interested in strategies in the design of kinase modulators, here's a comprehensive recent review www.nature.com/articles/s41...
rdcu.be/7nDDFUkn4W9a
rdcu.be/7nDDFUkn4W9a
Surprising non-transcriptional function for mediator kinase CDK8 in human DNA replication:
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
CDC7 and CDK8 kinases cooperate to support DNA replication origin firing in human cells - The EMBO Journal
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin-dependent kinases (CDKs), together with CDC7 kinase, are essential f...
link.springer.com
November 2, 2026 at 8:24 PM
Surprising non-transcriptional function for mediator kinase CDK8 in human DNA replication:
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
Corrado Santocanale & coworkers find it to cooperate with CDC7 in MCM helicase phosphorylation & activation–with implications for antiproliferative actions of CDC7 inhibitors
link.springer.com/article/10.1...
Long-range allosteric restraint by the Spiral-Pincer scaffold gates oxidative activation of the ATM kinase https://www.biorxiv.org/content/10.64898/2026.11.02.763569v1
November 3, 2026 at 4:17 PM
Long-range allosteric restraint by the Spiral-Pincer scaffold gates oxidative activation of the ATM kinase https://www.biorxiv.org/content/10.64898/2026.11.02.763569v1
A creatine kinase test is a blood test that measures levels of the enzyme creatine kinase. High levels can indicate several injuries and conditions.
What Is a Creatine Kinase Test and When Do You Need One?
A creatine kinase test is a blood test that measures levels of the enzyme creatine kinase. High levels can indicate several injuries and conditions.
bit.ly
November 2, 2026 at 9:00 PM
A creatine kinase test is a blood test that measures levels of the enzyme creatine kinase. High levels can indicate several injuries and conditions.
Seminar at the Seoul National University. "Receptor Kinase Signaling and Immunity-Stomatal Development Intersection". Thank you very much for the generous invitation!
October 31, 2026 at 12:06 AM
Seminar at the Seoul National University. "Receptor Kinase Signaling and Immunity-Stomatal Development Intersection". Thank you very much for the generous invitation!
Slender lobes is a spindle matrix protein regulated by spindle envelope kinase Greatwall in #oocytes. New study from Rayane Kaade, Hiroyuki Ohkura and colleagues @edinburgh-uni.bsky.social:
rupress.org/jcb/article/...
#Genetics #CellDivision #Development #Cytoskeleton #Meiosis #Drosophila
rupress.org/jcb/article/...
#Genetics #CellDivision #Development #Cytoskeleton #Meiosis #Drosophila
November 2, 2026 at 2:45 PM
Slender lobes is a spindle matrix protein regulated by spindle envelope kinase Greatwall in #oocytes. New study from Rayane Kaade, Hiroyuki Ohkura and colleagues @edinburgh-uni.bsky.social:
rupress.org/jcb/article/...
#Genetics #CellDivision #Development #Cytoskeleton #Meiosis #Drosophila
rupress.org/jcb/article/...
#Genetics #CellDivision #Development #Cytoskeleton #Meiosis #Drosophila
Just out: Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase ROCK
Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase ROCK
Communications Chemistry, Published online: 04 November 2026; doi:10.1038/s42004-026-02258-2Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase ROCK
dlvr.it
November 4, 2026 at 4:44 PM
Just out: Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase ROCK
Our latest research highlight covers a paper in Nature on the systematic design of bitopic kinase inhibitors www.nature.com/articles/d41...
Linking kinase inhibitors for greater selectivity
Discover the world’s best science and medicine | Nature.com
www.nature.com
November 4, 2026 at 3:16 PM
Our latest research highlight covers a paper in Nature on the systematic design of bitopic kinase inhibitors www.nature.com/articles/d41...
KINASE WINDMILLED
October 31, 2026 at 11:19 PM
KINASE WINDMILLED
The tomato cytoplasmic receptor-like kinase TPK09 mediates resistance to Botrytis cinerea and tolerance to light-induced stress (Sara Hailemariam , Chao-Jan Liao , Athanas Guzha , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
The tomato cytoplasmic receptor-like kinase TPK09 mediates resistance to Botrytis cinerea and tolerance to light-induced stress
Abstract. Plant responses to pathogens often rely on receptor-like cytoplasmic kinases (RLCKs) that mediate signaling through interactions with receptor ki
doi.org
October 30, 2026 at 4:03 PM
The tomato cytoplasmic receptor-like kinase TPK09 mediates resistance to Botrytis cinerea and tolerance to light-induced stress (Sara Hailemariam , Chao-Jan Liao , Athanas Guzha , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
Using mechanistic & structural insights by NMR, researchers report terazosin activates or inhibits human phosphoglycerate kinase 1 (PGK1) in a dose-dependent manner
pubs.acs.org/jaaucr/artic...
pubs.acs.org/jaaucr/artic...
October 31, 2026 at 1:52 PM
Using mechanistic & structural insights by NMR, researchers report terazosin activates or inhibits human phosphoglycerate kinase 1 (PGK1) in a dose-dependent manner
pubs.acs.org/jaaucr/artic...
pubs.acs.org/jaaucr/artic...
Single Molecule Diffusion Studies Reveal Rapid Translations Across Target Membrane Surfaces for both p40Phox PX domain and Class III PI3K VPS34 Complex 1, the Autophagy Lipid Kinase https://www.biorxiv.org/content/10.64898/2026.10.30.763023v1
November 2, 2026 at 3:48 PM
Single Molecule Diffusion Studies Reveal Rapid Translations Across Target Membrane Surfaces for both p40Phox PX domain and Class III PI3K VPS34 Complex 1, the Autophagy Lipid Kinase https://www.biorxiv.org/content/10.64898/2026.10.30.763023v1
somehow all of my lab work is normal again (except for my creatine kinase, but my brain won’t let me eat like an adult human, so). hmu for vitamin recs, i guess, because mine must be good.
October 30, 2026 at 10:01 PM
somehow all of my lab work is normal again (except for my creatine kinase, but my brain won’t let me eat like an adult human, so). hmu for vitamin recs, i guess, because mine must be good.
The scary thing here is that a committee of academic "scientists" had to collectively agree that burying "kinase kinase kinase kinase" behind the notation "4K" was a good idea that would help move the field forward.
October 31, 2026 at 12:08 PM
The scary thing here is that a committee of academic "scientists" had to collectively agree that burying "kinase kinase kinase kinase" behind the notation "4K" was a good idea that would help move the field forward.
Tour de force work from Brenda Shulman's lab shows how it pays to read papers published many decades ago.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
How metabolic enzyme levels are regulated is poorly understood. Studying the tryptophan
(Trp)-metabolizing enzyme TDO2, Thielen et al. discover a CK2 kinase-β-TrCP E3 ligase
pathway that regulates sta...
www.cell.com
October 28, 2026 at 11:24 PM
Tour de force work from Brenda Shulman's lab shows how it pays to read papers published many decades ago.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
📅New #PlantSciEvents Event Added: Receptor Kinase Signaling: Fueling Plant Resilience and Development
👉 buff.ly/FheN9RS
#PlantScience
👉 buff.ly/FheN9RS
#PlantScience
Receptor Kinase Signaling: Fueling Plant Resilience and Development
Plants require rapid and precise responses to constantly adapt to dynamic environmental and developmental cues. Receptor kinases (RKs), a vastly expanded protei
buff.ly
November 3, 2026 at 5:15 PM
📅New #PlantSciEvents Event Added: Receptor Kinase Signaling: Fueling Plant Resilience and Development
👉 buff.ly/FheN9RS
#PlantScience
👉 buff.ly/FheN9RS
#PlantScience
Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase https://www.biorxiv.org/content/10.64898/2026.10.27.762170v1
November 1, 2026 at 9:16 PM
Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase https://www.biorxiv.org/content/10.64898/2026.10.27.762170v1
Explore the molecular mechanisms driving tyrosine kinase inhibitor resistance in #LungCancer (#NSCLC).
This research reveals that MUC1-C maintains refractory phenotypes and represents a viable target for antibody-drug conjugates. @harvardmed.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This research reveals that MUC1-C maintains refractory phenotypes and represents a viable target for antibody-drug conjugates. @harvardmed.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
November 4, 2026 at 6:00 AM
Explore the molecular mechanisms driving tyrosine kinase inhibitor resistance in #LungCancer (#NSCLC).
This research reveals that MUC1-C maintains refractory phenotypes and represents a viable target for antibody-drug conjugates. @harvardmed.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This research reveals that MUC1-C maintains refractory phenotypes and represents a viable target for antibody-drug conjugates. @harvardmed.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Long-range allosteric restraint by the Spiral-Pincer scaffold gates oxidative activation of the ATM kinase https://www.biorxiv.org/content/10.64898/2026.11.02.763569v1
November 3, 2026 at 4:17 PM
Long-range allosteric restraint by the Spiral-Pincer scaffold gates oxidative activation of the ATM kinase https://www.biorxiv.org/content/10.64898/2026.11.02.763569v1
Cell Division Control protein 42 homolog Binding Protein kinase Alpha has a familiar architecture: an nward rigid kinase domain, a central dynamic pS decorated "interdomain" & a cward β-propellerish citron domain. In addition, it has a C-terminal dynamic […]
[Original post on mastodon.social]
[Original post on mastodon.social]
November 2, 2026 at 12:23 PM
Cell Division Control protein 42 homolog Binding Protein kinase Alpha has a familiar architecture: an nward rigid kinase domain, a central dynamic pS decorated "interdomain" & a cward β-propellerish citron domain. In addition, it has a C-terminal dynamic […]
[Original post on mastodon.social]
[Original post on mastodon.social]
Computational Repurposing of FDA Approved Drugs Against Cyclin Dependent Kinase (CDK2) https://www.biorxiv.org/content/10.64898/2026.10.27.762194v1
November 2, 2026 at 2:46 AM
Computational Repurposing of FDA Approved Drugs Against Cyclin Dependent Kinase (CDK2) https://www.biorxiv.org/content/10.64898/2026.10.27.762194v1
A ROP–effector–AGC kinase feedback loop regulates xylem pit patterning
En Li (李恩), et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
En Li (李恩), et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
October 30, 2026 at 9:56 PM
A ROP–effector–AGC kinase feedback loop regulates xylem pit patterning
En Li (李恩), et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
En Li (李恩), et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Computational Repurposing of FDA Approved Drugs Against Cyclin Dependent Kinase (CDK2) https://www.biorxiv.org/content/10.64898/2026.10.27.762194v1
November 2, 2026 at 2:46 AM
Computational Repurposing of FDA Approved Drugs Against Cyclin Dependent Kinase (CDK2) https://www.biorxiv.org/content/10.64898/2026.10.27.762194v1
NOP2/Sun domain 4-mediated m5C methylation of Janus kinase 1 promotes hepatocellular carcinoma progression
Cell adhesion & migration · Ke et al.
doi.org/10.1080/19336918.2026.2757921
#RNAsky #RNAmods
Cell adhesion & migration · Ke et al.
doi.org/10.1080/19336918.2026.2757921
#RNAsky #RNAmods
NOP2/Sun domain 4-mediated m5C methylation of Janus kinase 1 promotes hepatocellular carcinoma progression
Cell adhesion & migration · Ke J, Xu Y, Ding F, Chen Y, Li Z, Chen J.
doi.org
November 5, 2026 at 1:14 AM
NOP2/Sun domain 4-mediated m5C methylation of Janus kinase 1 promotes hepatocellular carcinoma progression
Cell adhesion & migration · Ke et al.
doi.org/10.1080/19336918.2026.2757921
#RNAsky #RNAmods
Cell adhesion & migration · Ke et al.
doi.org/10.1080/19336918.2026.2757921
#RNAsky #RNAmods