To determine the expression levels of various m6A modulators in human pancreatic cells, we reanalysed the PANC-DB scRNA-seq dataset29,30, which contains data from over 2 × 105 human pancreatic cells (Extended Data Fig. 1a). Focusing on non-diabetic samples, we plotted expression levels of m6A modulators across different pancreatic cell types (Extended Data Fig. 1b). Interestingly, among the endocrine cells, human α-cells exhibited among the highest expression levels of m6A editors and reader proteins, particularly when compared with insulin-producing β-cells (Extended Data Fig. 1c). To investigate whether m6A modulates transcriptional variability, we analysed transcriptional noise (transcriptional variability) in human α- and β-cells using the PANC-DB scRNA-seq data and categorized genes as m6A-tagged or non-tagged (we defined m6A-tagged genes as having a significant peak that was enriched in IP over input at twofold or more with a false discovery rate (FDR) <0.05) based on our m6A-seq data from non-diabetic human islets21,22. We found that m6A-tagged genes exhibited lower transcriptional noise in both human α- and β-cells compared with non-m6A-tagged genes (Extended Data Fig. 1d). These findings suggest that m6A plays a role in fine-tuning transcription in α-cells and may regulate α-cell biology, a feature shared by β-cells and reported by us previously21...

The Plant cell · Zhang Y, Li P, Hua C, Ma J, Kong KN, Zhang S, Wu X, Loi J, Choi IKY, He C, Jang IC, Shen L.

Pharmacological research · Huang B, Chen J, Jia J, Lin H, Chen X, Guo Y, Chen Z, Su S, Huang C.

Here we show that m6A is a key regulator of α-cell function and plasticity.

Molecular medicine reports · Guo F, He M, Li Y, Zhu K, Hu B.

Here, we develop sequencing- and mass spectrometry-based approaches to quantitatively map RNA PSs at single-nucleotide resolution.

m6A methylation acts as an epitranscriptomic regulator of endocrine cell identity in pancreatic islet alpha cells, with loss of m6A leading to impaired alpha cell identity, α- to β-cell conversion and...

Journal of molecular medicine (Berlin, Germany) · Tan J, Luo J, Li L, Chen D, Wang J, Ge C, Li P.

Here, we explored the regulation and function of circE7.

Applied biochemistry and biotechnology · Zhang H, Yang Y, Liu Z, Zhao F, Liang G.

Here, we performed a time-resolved transcriptomic and RNA editome analysis of neutrophils co-cultured with three hepatocellular carcinoma (HCC) cell lines using 293T cells as control.

Here we utilize molecular dynamics simulations of FTO-RNA cap complexes to identify conserved aromatic residues on the surface of FTO involved in 5' cap recognition.

Environmental pollution (Barking, Essex : 1987) · Khan A, Koher G, Khan T, Grant K, Hudson S, Zheng G, Lee HY, Vidar WS, Morales-Shnaider F, Chen J, Darfour-Oduro KA, Bha

Here, we combined ribosome profiling under conditions of mTOR inhibition and m⁶A mapping to identify distinct subsets of mRNAs that differ in their sensitivity to the suppression of cap-dependent initiation.

BJC reports · Filossi C, Isaac C, Jaafar M, Clézardin P, Moyret-Lalle C, Marcel V, Puppo M.

Chinese medical journal · Chen J, Tan Y, Xie W, Shi L, Quan H, Xiao H, Liu J, Mao X, Chen P, Luo J.

Cardiovascular research · Chen S, Shang X, Xu J, Fan Z, Zhang S, Li R, Liu M, Liu Z, Fan L, Liu J, Jin X, Zhou T.

We demonstrate the efficacy of PLTRF-m6A on different breast cell lines.

Journal of bioenergetics and biomembranes · Liu X, Gu Y, Yuan F.

We identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts their interaction with N6-methyladenosine (m6A)-modified RNAs.

Life sciences · Ji X, Zhang L, Zhu X, He J, Ju Y, Jin C, Ma W, Kong X, Guo H, Yu D, Zhao K.

In this study, we investigated the role of METTL7B and its association with m6A-related regulation of HK3 in pathological cardiac hypertrophy.

Journal of computer-aided molecular design · Xu C, Zhao S, Xu B, Xu J, Wu Y, Zhang D, Wu B, Zhou Q.