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RNA modification papers
@rnamod.bsky.social
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🦾🤖 posting/reposting RNA modification papers/preprints (automated)
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RNA modification papers @rnamod.bsky.social · 16d
#RNAsky #RNAmods
davidmcquarrie.bsky.social David McQuarrie @davidmcquarrie.bsky.social · Nov 21
Hi #RNAsky, I've made a much needed #RNA modifications starter pack!
Let me know if you’d like to be added or know someone who should be.
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Reposted by RNA modification papers
biorxiv-molbio.bsky.social
LARP1-DM15/Sgt is a reader for cap-adjacent 2`-O-ribose methylation in TOP ribosomal protein mRNAs required for localization to synapses https://www.biorxiv.org/content/10.64898/2026.09.17.752351v1
September 18, 2026 at 3:17 PM
Reposted by RNA modification papers
dariofdejesus.bsky.social
New paper out in @NatureMetabolism!

We show that loss of m⁶A disrupts pancreatic α-cell identity and promotes their transition toward immature β-cells.

My first as co-corresponding with lots of work from my new lab at @UChicago

www.nature.com/articles/s42...
m6A mRNA methylation regulates pancreatic α-cell plasticity - Nature Metabolism
m6A methylation acts as an epitranscriptomic regulator of endocrine cell identity in pancreatic islet alpha cells, with loss of m6A leading to impaired alpha cell identity, α- to β-cell conversion and...
www.nature.com
September 18, 2026 at 5:09 PM
rnamod.bsky.social
METTL3 mitigates age-related hearing loss by inhibiting NF-κB-mediated inflammatory responses through the m6A modification of NFKBIA

Journal of molecular medicine (Berlin, Germany) · Tan et al.
doi.org/10.1007/s00109-026-02714-5
#RNAsky #RNAmods
METTL3 mitigates age-related hearing loss by inhibiting NF-κB-mediated inflammatory responses through the m6A modification of NFKBIA
Journal of molecular medicine (Berlin, Germany) · Tan J, Luo J, Li L, Chen D, Wang J, Ge C, Li P.
doi.org
September 18, 2026 at 9:06 PM
rnamod.bsky.social
Regulation and function of the HPV16 CircE7 RNA

Journal of virology · Lee et al.
doi.org/10.1128/jvi.01284-26
#RNAsky #RNAmods
Regulation and function of the HPV16 CircE7 RNA
Here, we explored the regulation and function of circE7.
doi.org
September 18, 2026 at 9:06 PM
rnamod.bsky.social
RBM15 Contributes to Bladder Carcinoma Progression via m6A-dependent Stabilization of IFI6 mRNA

Applied biochemistry and biotechnology · Zhang et al.
doi.org/10.1007/s12010-026-05924-2
#RNAsky #RNAmods
RBM15 Contributes to Bladder Carcinoma Progression via m6A-dependent Stabilization of IFI6 mRNA
Applied biochemistry and biotechnology · Zhang H, Yang Y, Liu Z, Zhao F, Liang G.
doi.org
September 18, 2026 at 9:05 PM
rnamod.bsky.social
Dynamic reprogramming and A-to-I RNA editing in neutrophils in response to tumor induction

The Journal of biological chemistry · Cao et al.
doi.org/10.1016/j.jbc.2026.113569
#RNAsky #RNAmods
Dynamic reprogramming and A-to-I RNA editing in neutrophils in response to tumor induction
Here, we performed a time-resolved transcriptomic and RNA editome analysis of neutrophils co-cultured with three hepatocellular carcinoma (HCC) cell lines using 293T cells as control.
doi.org
September 18, 2026 at 9:05 PM
Reposted by RNA modification papers
medrxivpreprint.bsky.social
Altered m6A methylation across eight reward- and motor-related brain regions in alcohol use disorder https://www.medrxiv.org/content/10.64898/2026.09.16.26363234v1
September 18, 2026 at 4:55 AM
rnamod.bsky.social
RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation

The Journal of biological chemistry · Shimanski et al.
doi.org/10.1016/j.jbc.2026.113573
#RNAsky #RNAmods
RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation
Here we utilize molecular dynamics simulations of FTO-RNA cap complexes to identify conserved aromatic residues on the surface of FTO involved in 5' cap recognition.
doi.org
September 18, 2026 at 1:18 PM
rnamod.bsky.social
Polystyrene microplastic uptake drives Inflammatory, Epitranscriptomic, and Metabolic Reprogramming in Human Aortic Endothelial cells

Environmental pollution (Barking, Essex : 1987) · Khan et al.
doi.org/10.1016/j.envpol.2026.129187
#RNAsky #RNAmods
Polystyrene microplastic uptake drives Inflammatory, Epitranscriptomic, and Metabolic Reprogramming in Human Aortic Endothelial cells
Environmental pollution (Barking, Essex : 1987) · Khan A, Koher G, Khan T, Grant K, Hudson S, Zheng G, Lee HY, Vidar WS, Morales-Shnaider F, Chen J, Darfour-Oduro KA, Bha
doi.org
September 18, 2026 at 1:17 PM
rnamod.bsky.social
Transcript-wide m6A methylation defines the efficiency of cap-independent translation initiation

RNA (New York, N.Y.) · Smolin et al.
doi.org/10.1261/rna.081017.126
#RNAsky #RNAmods
Transcript-wide m6A methylation defines the efficiency of cap-independent translation initiation
Here, we combined ribosome profiling under conditions of mTOR inhibition and m⁶A mapping to identify distinct subsets of mRNAs that differ in their sensitivity to the suppression of cap-dependent initiation.
doi.org
September 18, 2026 at 1:17 PM
rnamod.bsky.social
MiR-662 impairs C/D box snoRNA expression and rRNA 2'-O-ribose methylation marks

BJC reports · Filossi et al.
doi.org/10.1038/s44276-026-00247-5
#RNAsky #RNAmods
MiR-662 impairs C/D box snoRNA expression and rRNA 2'-O-ribose methylation marks
BJC reports · Filossi C, Isaac C, Jaafar M, Clézardin P, Moyret-Lalle C, Marcel V, Puppo M.
doi.org
September 18, 2026 at 1:17 PM
rnamod.bsky.social
Sublethal heat stress-induced HSF4 upregulation via GRSF1 in an m6A-dependent manner in hepatocellular carcinoma

Chinese medical journal · Chen et al.
doi.org/10.1097/cm9.0000000000004188
#RNAsky #RNAmods
Sublethal heat stress-induced HSF4 upregulation via GRSF1 in an m6A-dependent manner in hepatocellular carcinoma
Chinese medical journal · Chen J, Tan Y, Xie W, Shi L, Quan H, Xiao H, Liu J, Mao X, Chen P, Luo J.
doi.org
September 18, 2026 at 1:16 PM
Reposted by RNA modification papers
genesndiseases.bsky.social
Decoding thyroid cancer progression requires understanding #m6A‑regulated drivers.
IGF2BP2 is upregulated in #PapillaryThyroidCarcinoma, promoting malignancy via SPRY1 and MAPK/MEK/ERK signaling, enhanced by TGF‑β/SMAD4.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 17, 2026 at 4:20 PM
rnamod.bsky.social
Oscillatory shear stress-induced endothelial extracellular vesicles exacerbate aortic valve calcification

Cardiovascular research · Chen et al.
doi.org/10.1093/cvr/cvag205
#RNAsky #RNAmods
Oscillatory shear stress-induced endothelial extracellular vesicles exacerbate aortic valve calcification
Cardiovascular research · Chen S, Shang X, Xu J, Fan Z, Zhang S, Li R, Liu M, Liu Z, Fan L, Liu J, Jin X, Zhou T.
doi.org
September 17, 2026 at 9:07 PM
rnamod.bsky.social
Accurate imaging of m6A on specific mRNA with proximity ligation-triggered RCA-FISH (PLTRF-m6A)

Chemical communications (Cambridge, England) · Cao et al.
doi.org/10.1039/d6cc04660f
#RNAsky #RNAmods
Accurate imaging of m6A on specific mRNA with proximity ligation-triggered RCA-FISH (PLTRF-m6A)
We demonstrate the efficacy of PLTRF-m6A on different breast cell lines.
doi.org
September 17, 2026 at 9:06 PM
rnamod.bsky.social
FTO-mediated GPX4 m6A modification in ferroptosis-induced DNA damage and inflammatory response during acute lung injury

Journal of bioenergetics and biomembranes · Liu et al.
doi.org/10.1007/s10863-026-10133-x
#RNAsky #RNAmods
FTO-mediated GPX4 m6A modification in ferroptosis-induced DNA damage and inflammatory response during acute lung injury
Journal of bioenergetics and biomembranes · Liu X, Gu Y, Yuan F.
doi.org
September 17, 2026 at 9:06 PM
rnamod.bsky.social
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway

Cell reports. Medicine · Zhou et al.
doi.org/10.1016/j.xcrm.2026.103045
#RNAsky #RNAmods
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway
We identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts their interaction with N6-methyladenosine (m6A)-modified RNAs.
doi.org
September 17, 2026 at 9:06 PM
rnamod.bsky.social
Targeting IGF2BP3-driven CSF1/CSF1R signaling disrupts the positive feedback loop between tumor cells and macrophages and inhibits HCC progression

Life sciences · Ji et al.
doi.org/10.1016/j.lfs.2026.124681
#RNAsky #RNAmods
Targeting IGF2BP3-driven CSF1/CSF1R signaling disrupts the positive feedback loop between tumor cells and macrophages and inhibits HCC progression
Life sciences · Ji X, Zhang L, Zhu X, He J, Ju Y, Jin C, Ma W, Kong X, Guo H, Yu D, Zhao K.
doi.org
September 17, 2026 at 1:20 PM
rnamod.bsky.social
METTL7B attenuates pathological cardiac hypertrophy via m6A-associated regulation of HK3

Molecular and cellular biochemistry · Bao et al.
doi.org/10.1007/s11010-026-05737-1
#RNAsky #RNAmods
METTL7B attenuates pathological cardiac hypertrophy via m6A-associated regulation of HK3
In this study, we investigated the role of METTL7B and its association with m6A-related regulation of HK3 in pathological cardiac hypertrophy.
doi.org
September 17, 2026 at 1:20 PM
rnamod.bsky.social
Structure-guided identification and experimental validation of NAT10-targeting small molecules in colorectal cancer cells

Journal of computer-aided molecular design · Xu et al.
doi.org/10.1007/s10822-026-00890-7
#RNAsky #RNAmods
Structure-guided identification and experimental validation of NAT10-targeting small molecules in colorectal cancer cells
Journal of computer-aided molecular design · Xu C, Zhao S, Xu B, Xu J, Wu Y, Zhang D, Wu B, Zhou Q.
doi.org
September 17, 2026 at 1:20 PM
rnamod.bsky.social
Potent halt of SARS-CoV-2 replication using clitocine-induced emergent-viral-RNA editing and disruption

RSC advances · Rabie et al.
doi.org/10.1039/d6ra00276e
#RNAsky #RNAmods
Potent halt of SARS-CoV-2 replication using clitocine-induced emergent-viral-RNA editing and disruption
RSC advances · Rabie AM, El Idrissi IG.
doi.org
September 17, 2026 at 1:19 PM
rnamod.bsky.social
Human m6A demethylase FTO modulates the flowering time of tomato plants under low-temperature stress

Plant physiology and biochemistry : PPB · Amara et al.
doi.org/10.1016/j.plaphy.2026.111754
#RNAsky #RNAmods
Human m6A demethylase FTO modulates the flowering time of tomato plants under low-temperature stress
Here, we investigated whether ectopic expression of FTO, a well-characterized human m6A demethylase, influences flowering and post-transcriptional behaviour in tomato (Solanum lycopersicum) under LT conditions.
doi.org
September 17, 2026 at 1:19 PM
rnamod.bsky.social
Detection and sequencing of Ap2N-capped RNAs in human cells

Proceedings of the National Academy of Sciences of the United States of America · Vopalensky et al.
doi.org/10.1073/pnas.2608168123
#RNAsky #RNAmods
Detection and sequencing of Ap2N-capped RNAs in human cells
We report here on the detection and quantification of a new type of RNA cap-diadenosine diphosphate (Ap2A) and adenosine guanosine diphosphate (Ap2G)-on mammalian RNA.
doi.org
September 16, 2026 at 9:08 PM
rnamod.bsky.social
Ten-year outcomes of PET-directed salvage nodal radiotherapy and temporary ADT for N1 and M1a hormone-sensitive prostate cancer

Practical radiation oncology · Salazar et al.
doi.org/10.1016/j.prro.2026.09.003
#RNAsky #RNAmods
Ten-year outcomes of PET-directed salvage nodal radiotherapy and temporary ADT for N1 and M1a hormone-sensitive prostate cancer
Practical radiation oncology · Salazar V CJ, Wilhite TJ, Stish BJ, Phillips RM, Harmsen WS, Waddle MR, Park SS, Jethwa KR, Orme JJ, Childs DS, Mynderse
doi.org
September 16, 2026 at 9:07 PM
rnamod.bsky.social
Arsenic-induced SAM depletion and m6A dysregulation contribute to impaired insulin secretion in MIN6 cells

Toxicology · Yang et al.
doi.org/10.1016/j.tox.2026.154587
#RNAsky #RNAmods
Arsenic-induced SAM depletion and m6A dysregulation contribute to impaired insulin secretion in MIN6 cells
Toxicology · Yang H, Yuan H, Tai Y, Chen X, Yang X, Chen C, Liu L, Zhang Q, Tang N.
doi.org
September 16, 2026 at 9:07 PM