#RNAmods
Multivalent ADAR1 recruitment for precise RNA editing

Nature methods
doi.org/10.1038/s41592-026-03285-6
#RNAsky #RNAmods
Multivalent ADAR1 recruitment for precise RNA editing
Nature methods
doi.org
October 31, 2026 at 5:37 PM
Mxd1-mediated transcriptional repression of FTO induces NLRP3-dependent pyroptosis in retinal microglia

Experimental cell research · Zhang et al.
doi.org/10.1016/j.yexcr.2026.115194
#RNAsky #RNAmods
Mxd1-mediated transcriptional repression of FTO induces NLRP3-dependent pyroptosis in retinal microglia
Experimental cell research · Zhang Y, Yang Y, Xu X.
doi.org
October 30, 2026 at 12:32 AM
RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA

Science advances · Ganem et al.
doi.org/10.1126/sciadv.aed7314
#RNAsky #RNAmods
RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA
We show that ADARs interfere with the efficacy of exogenous RNAi in vivo, likely to prevent trans-silencing, and provide evidence that ADR-2 binding to dsRNA is required for efficient RNAi suppression.
doi.org
October 31, 2026 at 5:38 PM
Aptamer-mediated multivalent endogenous ADAR1 recruitment for highly efficient RNA editing

Nature methods · Zhu et al.
doi.org/10.1038/s41592-026-03284-7
#RNAsky #RNAmods
Aptamer-mediated multivalent endogenous ADAR1 recruitment for highly efficient RNA editing
Here we introduce MARRS (multivalent ADAR1-recruiting RNA editing system)-an efficient and specific RNA editing platform that leverages engineered multivalent RNA aptamers to robustly recruit endogenous ADAR1 enzymes.
doi.org
October 30, 2026 at 12:32 AM
ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation

Acta pharmacologica Sinica · Li et al.
doi.org/10.1038/s41401-026-01951-1
#RNAsky #RNAmods
ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation
Acta pharmacologica Sinica · Li ZH, Li MX, Song YH, Ren RH, Zhang TT, Huang WJ, Harry AM, Shah KA, Wang YY, Liu ZJ, Chen HY, Qian SH, Xu Z, Zhang JR,
doi.org
October 30, 2026 at 6:33 PM
Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers

Nature · Yankova et al.
doi.org/10.1038/s41586-026-11178-z
#RNAsky #RNAmods
Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers
Here we present the development and characterization of STM9005, a highly selective and potent first-in-class tRNA methyltransferase inhibitor of METTL1.
doi.org
October 30, 2026 at 12:31 AM
CircCCNB1 Inhibits Ferroptosis in Glioblastoma Cells via the USP4/IGF2BP1/SLC7A11 Axis

Neurochemical research · Cui et al.
doi.org/10.1007/s11064-026-04943-z
#RNAsky #RNAmods
CircCCNB1 Inhibits Ferroptosis in Glioblastoma Cells via the USP4/IGF2BP1/SLC7A11 Axis
Neurochemical research · Cui S, Zhuang Y, Wei H, Xiong H, He Z.
doi.org
November 2, 2026 at 10:16 PM
Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models

Molecular biology reports · Yıldırım et al.
doi.org/10.1007/s11033-026-13074-1
#RNAsky #RNAmods
Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models
Molecular biology reports · Yıldırım ME, Ayhan B, Çelik H.
doi.org
November 2, 2026 at 12:06 AM
NUDT21 Promotes Myelodysplastic Syndrome Progression by Regulating SRSF2 Expression via Alternative Polyadenylation

Hematological oncology · Guan et al.
doi.org/10.1002/hon.70255
#RNAsky #RNAmods
NUDT21 Promotes Myelodysplastic Syndrome Progression by Regulating SRSF2 Expression via Alternative Polyadenylation
Hematological oncology · Guan D, Xu W, Li S, Li P, Bian J, Wang H, Ren F.
doi.org
November 1, 2026 at 6:22 PM
YTHDF1 promotes radioresistance in nasopharyngeal carcinoma through the SATB1/Wnt/β-catenin pathway

Molecular and cellular probes · Liao et al.
doi.org/10.1016/j.mcp.2026.102092
#RNAsky #RNAmods
YTHDF1 promotes radioresistance in nasopharyngeal carcinoma through the SATB1/Wnt/β-catenin pathway
Molecular and cellular probes · Liao B, Zhang L, Zou Q, Wang M, Liu J, Guo L, Zhou Z, Yi Y.
doi.org
November 2, 2026 at 12:06 AM
WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis

iScience · Li et al.
doi.org/10.1016/j.isci.2026.117958
#RNAsky #RNAmods
WTAP-mediated m6A methylation stabilizes pIgR mRNA and attenuates smoke-induced epithelial inflammation and apoptosis
We show that smoke exposure downregulates the m6A writer-complex component WTAP and reduces global m6A methylation.
doi.org
November 2, 2026 at 12:05 AM
METTL7B-Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression

Cancer medicine · Lin et al.
doi.org/10.1002/cam4.72373
#RNAsky #RNAmods
METTL7B-Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression
Cancer medicine · Lin W, Wu K, Chen J, Yu Z, Zhang H, Chen X.
doi.org
November 1, 2026 at 6:21 PM
Diverse RNA Editing Systems Across Heterolobosea (Discoba)

RNA (New York, N.Y.) · Mirzoyan et al.
doi.org/10.1261/rna.080828.125
#RNAsky #RNAmods
Diverse RNA Editing Systems Across Heterolobosea (Discoba)
RNA (New York, N.Y.) · Mirzoyan S, Corre P, Zadrobilkova E, Panek T.
doi.org
October 29, 2026 at 6:55 PM
METTL3-mediated N6-methyladenosine modification of UHRF1 promotes osteosarcoma malignancy through silencing SFRP1 via DNA methylation

Molecular biology reports · Ye et al.
doi.org/10.1007/s11033-026-12882-9
#RNAsky #RNAmods
METTL3-mediated N6-methyladenosine modification of UHRF1 promotes osteosarcoma malignancy through silencing SFRP1 via DNA methylation
Molecular biology reports · Ye K, Zhou H, Ma Y, Shen W.
doi.org
October 31, 2026 at 11:53 PM
FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · Guimarães-Teixeira et al.
doi.org/10.1016/j.biopha.2026.120009
#RNAsky #RNAmods
FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · Guimarães-Teixeira C, Nunes SP, Bueno-Costa A, Martinez-Verbo L, Duarte IF, Carriço ÍR, Barros-Silva D, Lobo J, Henrique
doi.org
November 2, 2026 at 12:07 AM
Fat mass and obesity-associated protein mediates MKL-1 m6A demethylation to induce resistance to ferroptosis in breast cancer cells

Bulletin du cancer · Peng et al.
doi.org/10.1016/j.bulcan.2026.09.009
#RNAsky #RNAmods
Fat mass and obesity-associated protein mediates MKL-1 m6A demethylation to induce resistance to ferroptosis in breast cancer cells
Bulletin du cancer · Peng ZT, Hu R, Wu Y.
doi.org
October 31, 2026 at 5:38 PM
Melatonin Suppresses Colorectal Cancer Alongside Coordinated Changes in H3K4me3Q5ser and m6A Modifications

Journal of pineal research · Zhang et al.
doi.org/10.1111/jpi.70192
#RNAsky #RNAmods
Melatonin Suppresses Colorectal Cancer Alongside Coordinated Changes in H3K4me3Q5ser and m6A Modifications
Journal of pineal research · Zhang W, Yuan L, Yu D, Qi S, Liu C, Wang D, Wang W, Zhang Y, Zhang S, Lu L, Wu M, Huang Y.
doi.org
November 1, 2026 at 6:21 PM
FTO deficiency mediates ferroptosis to exacerbate cobalt-induced neurotoxicity

Environmental research · Tang et al.
doi.org/10.1016/j.envres.2026.126027
#RNAsky #RNAmods
FTO deficiency mediates ferroptosis to exacerbate cobalt-induced neurotoxicity
Environmental research · Tang J, Ren Y, Zhou J, Liang B, Chen S, Li J, Huang H, Xu L, Li H.
doi.org
October 30, 2026 at 12:32 AM
In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling

Nature chemical biology · Chen et al.
doi.org/10.1038/s41589-026-02356-1
#RNAsky #RNAmods
In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling
Here we introduce H2O2-independent APEX2 (Hi-APEX), which uses a clickable tetrazine-phenol (TP) probe, requiring no enzyme engineering.
doi.org
October 30, 2026 at 6:32 PM
Catalytic efficiency of predicted deleterious missense variants of human DNA dioxygenase ABH2

DNA repair · Sagalakova et al.
doi.org/10.1016/j.dnarep.2026.103977
#RNAsky #RNAmods
Catalytic efficiency of predicted deleterious missense variants of human DNA dioxygenase ABH2
In this study, we functionally characterized eight ABH2 variants featuring SNVs-associated substitutions G103R, S125L, S188F, F195S, M226T, R248Q, R248W, or T252I, that had been previously (Davletgildeeva et al.
doi.org
October 31, 2026 at 5:37 PM
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2

Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2
Molecular and cellular biochemistry · Yan WZ, Wang JY, Chen YY, Zhang M, Liu GY, He LY.
doi.org
November 2, 2026 at 10:16 PM
FTO Dependent Trim14 m6A Modification Regulates Neuroinflammation in MPTP-Induced Parkinson's Disease Models via the RhoA/ROCK Pathway

Molecular neurobiology · Liu et al.
doi.org/10.1007/s12035-026-06299-5
#RNAsky #RNAmods
FTO Dependent Trim14 m6A Modification Regulates Neuroinflammation in MPTP-Induced Parkinson's Disease Models via the RhoA/ROCK Pathway
Here, we explored whether m6A modification is associated with microglia-mediated inflammation using MPTP-treated mice and MPP+-exposed BV2 cells.
doi.org
October 31, 2026 at 5:38 PM
A Biomimetic Multistage RNAi Platform Restores Mitochondrial Function in Diabetic Wounds via the ALKBH5-m6A-C2orf69 Axis

Advanced healthcare materials · Yan et al.
doi.org/10.1002/adhm.71922
#RNAsky #RNAmods
A Biomimetic Multistage RNAi Platform Restores Mitochondrial Function in Diabetic Wounds via the ALKBH5-m6A-C2orf69 Axis
Here, we identified a previously unrecognized N6-methyladenosine (m6A)-dependent mechanism underlying endothelial injury in diabetic wounds.
doi.org
October 30, 2026 at 6:32 PM
m⁶A presence and dosage are associated with IGF2BP2 binding, RNA abundance, and translation in mouse heart and liver

RNA (New York, N.Y.) · Liu et al.
doi.org/10.1261/rna.081163.126
#RNAsky #RNAmods
m⁶A presence and dosage are associated with IGF2BP2 binding, RNA abundance, and translation in mouse heart and liver
We identify a genome-wide presence-dosage pattern of m⁶A-associated gene regulation.
doi.org
October 30, 2026 at 6:32 PM
SLC3A2 Drives an Immunosuppressive Metabolic Axis that Limits Oncolytic Virotherapy Efficacy

Cancer research · Dai et al.
doi.org/10.1158/0008-5472.can-26-1659
#RNAsky #RNAmods
SLC3A2 Drives an Immunosuppressive Metabolic Axis that Limits Oncolytic Virotherapy Efficacy
Cancer research · Dai W, Hai R, Bian S, Dong Y, Yin B, Chen Y, Chen X, Fan Z, Cai Y, Shu M.
doi.org
October 29, 2026 at 6:56 PM