#GenesAndDiseases
Could STEAP4⁺ neutrophils signal #LungMetastasis?
Their circulating levels distinguished #BreastCancer patients with lung metastases from those with localized tumors, suggesting #biomarker potential. @pku1898.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 12:00 PM
Suppressing #neutrophils risks weakening antimicrobial defence.
Zebrafish screening identified epothilone B as a potential #IBD therapy, promoting neutrophil #apoptosis to reduce inflammation and support intestinal repair.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 4, 2026 at 11:01 PM
Why are fatty liver grafts more vulnerable to #transplant-related injury?
Extracellular vesicles deliver #ACSL4, triggering ferroptosis and mitochondrial damage, revealing a potential target to protect #LiverGrafts.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 4, 2026 at 3:30 PM
Overcoming #ChemotherapyResistance remains a major challenge.
This study identifies #m6A-modified circLPAR3 as a driver of docetaxel resistance in #ProstateCancer, highlighting a potential target for restoring treatment response.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 2:01 PM
Can excess salt worsen #AtopicDermatitis?
#HighSalt activates SGK-1–mTOR signaling, weakening the #SkinBarrier and promoting inflammation; combined SGK-1 and JAK inhibition eased symptoms in preclinical models.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 10:30 PM
How do #NeuralStemCells shape #microglial behavior?

This study reveals that CCN1 regulates microglial distribution and activation through region-specific CSF1 and IL2 signaling during #BrainDevelopment. #SpatialTranscriptomics

#GenesAndDiseases: doi.org/10.1016/j.ge...
November 2, 2026 at 6:29 AM
Can STING activation help eliminate #TCellMalignancies?
This study reveals how neoliensinine triggers lysosome-dependent cell death in T-cell malignancies by disrupting #CholesterolHomeostasis through the STING–TUBA1B pathway.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
November 1, 2026 at 9:01 AM
Can routine blood tests predict preeclampsia?
This study shows that routine #FirstTrimester markers combined with #AI improve #preeclampsia prediction, enabling earlier risk identification and management. @fudan-university.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 4, 2026 at 2:02 PM
Precise gene regulation is essential for proper heart development.
This study reveals how Dlc1 deficiency activates #WntSignaling, disrupting #CardiacProgenitor differentiation and later #cardiomyocyte generation.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 31, 2026 at 11:30 AM
Does #aging increase drug-induced #kidney injury?

A 3D silk-fiber model revealed greater #tenofovir-induced mitochondrial dysfunction and oxidative stress in elderly donor-derived renal stem cells. @wakeforest.bsky.social

#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
November 2, 2026 at 3:31 PM
Cancer’s hidden regulators are often overlooked.
This study identifies psiTPTE22-HERV as a #TumourSuppressor in #GastricCancer, showing that its epigenetic silencing promotes disease, while low expression predicts poorer survival.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 3:54 PM
What happens when MED14 fails to properly coordinate gene expression during #embryogenesis?
This study links a #MED14 mutation to VACTERL-like defects by impairing gene expression and multi-organ development. #RNApolymeraseII
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 30, 2026 at 10:30 PM
A stem cell weakness emerges.
This study identifies γH2AX as a key driver of #glioblastoma stemness and #tumour growth, highlighting the SET-PP2A axis as a promising target for limiting recurrence and invasion. #H2AX
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 30, 2026 at 3:19 PM
Lung repair depends on coordinated communication between epithelial cells and immune cells.
This study reveals how TAZ promotes IL-6 expression and #M2macrophage polarization, helping protect against #hypoxia-induced #LungInjury.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 1, 2026 at 3:06 PM
#RespiratoryPathogens exploit gaps in airway defense.
This review explores how #MucosalVaccines & inhalable antibodies could strengthen local immunity, improve protection, and advance prevention against #RespiratoryInfections.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 29, 2026 at 12:00 AM
Drug resistance may be spreading between cancer cells.
This study identifies CCT2 as a driver of #HNSCC progression and #CisplatinResistance, revealing it as a target & showing resistant cells can transfer CCT2 to promote #chemoresistance.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 1, 2026 at 12:30 AM
Not all cancer drivers encode proteins.

This study identifies the lncRNA SERHL as a suppressor of #GastricCancer progression, revealing its potential as a #biomarker and therapeutic target through inhibition of KLF16 signalling.

#GenesAndDiseases: doi.org/10.1016/j.ge...
November 2, 2026 at 12:01 PM
Aggressive #CervicalCancer evades immune defenses.
This study identifies DLL3 as a driver of #tumor progression and T-cell exhaustion in neuroendocrine cervical carcinoma, revealing a promising therapeutic target. @fudanuni_official
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 31, 2026 at 2:02 PM
Resistance remains breast cancer’s toughest obstacle.
This review highlights how #miRNAs regulate apoptosis & treatment response in #BreastCancer, revealing their potential as #radiosensitisers that could help overcome therapy resistance.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 30, 2026 at 1:03 PM
Lipid imbalance can drive diseases from #diabetes to neurodegeneration.
This review explores how lipophagy reduces oxidative stress and offers new therapeutic strategies for metabolic, cardiovascular, and neurological disorders.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 30, 2026 at 8:30 AM
Why does EGFR targeting often fail in #TNBC?
This review explores #EGFR expression patterns, co-targeting strategies, and #nanocarrier-based delivery systems to improve treatment efficacy and enable personalized care.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 28, 2026 at 1:31 PM
Could #epilepsy begin beyond the brain?
This review links #AirPollution, lung dysbiosis, and the #LungBrainAxis to #epileptogenesis, offering new perspectives for understanding and treating epilepsy. @monashuniversity.bsky.social
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 29, 2026 at 2:54 PM
How do cells sense forces during orthodontic treatment?
This review explores how #PiezoChannels regulate tooth movement, #dentofacial deformities, and pain, revealing potential targets for improved #orthodontic care.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 27, 2026 at 3:54 PM
Could #PrecisionNutrition improve cancer care?
This review explores how diet, gut microbes, and systemic metabolism shape tumor growth and treatment response, highlighting #AI and multi-omics for personalized #oncology.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 26, 2026 at 1:06 PM
Could targeting mitochondrial dysfunction help fight aggressive breast cancer?
This review explores how disrupted #MitochondrialDynamics drives #TNBC growth and chemoresistance, revealing new therapeutic opportunities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 26, 2026 at 11:30 PM