Emerging roles of microtubules in directional cardiomyocyte remodeling
Emerging roles of microtubules in directional cardiomyocyte remodeling
Past research has long hinted at a connection between microtubules and the growth of the heart. Here, we highlight a new role for microtubules in directing cardiomyocyte hypertrophy by altering protein translation and intercellular adhesion and discuss how these findings illuminate open questions in cardiac remodeling.
dlvr.it
October 30, 2026 at 12:02 PM
Emerging roles of microtubules in directional cardiomyocyte remodeling
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
chuckyscarnage.tech.blog
November 1, 2026 at 6:57 PM
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
October 30, 2026 at 10:30 PM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling https://www.biorxiv.org/content/10.64898/2026.10.30.762532v1
November 2, 2026 at 6:00 PM
Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling https://www.biorxiv.org/content/10.64898/2026.10.30.762532v1
Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling https://www.biorxiv.org/content/10.64898/2026.10.30.762532v1
November 2, 2026 at 6:00 PM
Long-PDE4D degradation attenuates left ventricular cardiomyocyte hypertrophic remodelling https://www.biorxiv.org/content/10.64898/2026.10.30.762532v1
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy
https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
November 2, 2026 at 9:38 AM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy
https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
Precise gene regulation is essential for proper heart development.
This study reveals how Dlc1 deficiency activates #WntSignaling, disrupting #CardiacProgenitor differentiation and later #cardiomyocyte generation.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This study reveals how Dlc1 deficiency activates #WntSignaling, disrupting #CardiacProgenitor differentiation and later #cardiomyocyte generation.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 31, 2026 at 11:30 AM
Precise gene regulation is essential for proper heart development.
This study reveals how Dlc1 deficiency activates #WntSignaling, disrupting #CardiacProgenitor differentiation and later #cardiomyocyte generation.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This study reveals how Dlc1 deficiency activates #WntSignaling, disrupting #CardiacProgenitor differentiation and later #cardiomyocyte generation.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
October 30, 2026 at 10:30 PM
Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy https://www.biorxiv.org/content/10.64898/2026.10.26.762072v1
ICYMI: New online: EMC chaperone activity is required for cotranslational calcium channel assembly
EMC chaperone activity is required for cotranslational calcium channel assembly
Nature Structural & Molecular Biology, Published online: 30 October 2026; doi:10.1038/s41594-026-01916-2Stanton et al. show that the human endoplasmic reticulum membrane protein complex (EMC) engages nascent calcium channels cotranslationally as a chaperone as part of a large ribosome–multipass translocon–EMC supercomplex. Loss of this function impairs channel biogenesis and disrupts cardiomyocyte contraction.
dlvr.it
October 31, 2026 at 1:45 PM
ICYMI: New online: EMC chaperone activity is required for cotranslational calcium channel assembly
Ankyrin-B regulates cardiomyocyte sarcomere organization and its protein-protein interactions are significantly altered by p.S646F expression https://www.biorxiv.org/content/10.64898/2026.10.29.762332v1
October 30, 2026 at 8:30 PM
Ankyrin-B regulates cardiomyocyte sarcomere organization and its protein-protein interactions are significantly altered by p.S646F expression https://www.biorxiv.org/content/10.64898/2026.10.29.762332v1
Ankyrin-B regulates cardiomyocyte sarcomere organization and its protein-protein interactions are significantly altered by p.S646F expression https://www.biorxiv.org/content/10.64898/2026.10.29.762332v1
October 30, 2026 at 8:30 PM
Ankyrin-B regulates cardiomyocyte sarcomere organization and its protein-protein interactions are significantly altered by p.S646F expression https://www.biorxiv.org/content/10.64898/2026.10.29.762332v1
RRIDs were included in this in Nature Cardiovascular Research paper. We value the author's support of reproducibility. #ReproducibleResearch #reproducibility #STMpublishing
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity - Nature Cardiovascular Research
Minerath et al. show that cardiomyocyte-derived TGFβ orchestrates a developmental signaling network that is essential for heart maturation. By communicating with non-myocytes, TGFβ promotes cardiomyocyte identity, whereas its loss disrupts fibroblast maturation and activates skeletal muscle gene programs in cardiomyocytes.
doi.org
October 30, 2026 at 7:08 AM
RRIDs were included in this in Nature Cardiovascular Research paper. We value the author's support of reproducibility. #ReproducibleResearch #reproducibility #STMpublishing
DGD Volume 68, Issue 9 was released!!
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
November 3, 2026 at 11:45 PM
DGD Volume 68, Issue 9 was released!!
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
https://doi.org/10.1111/dgd.70059
Cover: The relationship between RNA‐binding protein expression and the proliferative capacity of mouse cardiomyocytes. A positive correlation is observed between the KH_1 domain‐containing gene expression and cardiomyocyte prol…
New online: EMC chaperone activity is required for cotranslational calcium channel assembly
EMC chaperone activity is required for cotranslational calcium channel assembly
Nature Structural & Molecular Biology, Published online: 30 October 2026; doi:10.1038/s41594-026-01916-2Stanton et al. show that the human endoplasmic reticulum membrane protein complex (EMC) engages nascent calcium channels cotranslationally as a chaperone as part of a large ribosome–multipass translocon–EMC supercomplex. Loss of this function impairs channel biogenesis and disrupts cardiomyocyte contraction.
dlvr.it
October 30, 2026 at 1:44 PM
New online: EMC chaperone activity is required for cotranslational calcium channel assembly
Murillo et al. find Inhibition of DYRK1A using LCTB-92 induces cardiomyocyte proliferation and improves heart function in a mouse model of myocardial infarction with reperfusion: doi.org/10.1172/jci....
@the-asci.org
@the-asci.org
October 28, 2026 at 4:07 PM
Murillo et al. find Inhibition of DYRK1A using LCTB-92 induces cardiomyocyte proliferation and improves heart function in a mouse model of myocardial infarction with reperfusion: doi.org/10.1172/jci....
@the-asci.org
@the-asci.org
Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury: doi.org/10.1172/jci....
JCI Insight - Network modeling predicts how DYRK1A inhibition promotes cardiomyocyte cycling after ischemia/reperfusion injury
Research ArticleCardiologyCell biology Open Access | 10.1172/jci.insight.200429
doi.org
October 28, 2026 at 4:07 PM
Network Modeling Predicts How DYRK1A Inhibition Promotes Cardiomyocyte Cycling after Ischemic/Reperfusion Injury: doi.org/10.1172/jci....
and further exacerbates insuli
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
October 28, 2026 at 4:40 AM
and further exacerbates insuli
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
🫀 #Cardiomyocyte Injury and Pyroptosis: Accumulation of BCAAs heightens both acute and chronic myocardial injury, deteriorates cardiac function, and activates pyroptosis in cardiomyocytes via NLRP3/ASC/Caspase-1 signaling pathways.
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
October 26, 2026 at 2:47 AM
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
They used human cardiac spheroids made of cardiomyocytes and fibroblasts to characterize the response to cardiac injury in this model (no proliferation, rather fibrotic response).
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
Development of a laser injury model using human cardiac spheroids
Summary: We report the establishment of a human cardiac microtissue injury model using focal laser ablation to investigate cardiomyocyte–fibroblast interactions during reparative and regenerative proc...
journals.biologists.com
October 29, 2026 at 1:34 PM
They used human cardiac spheroids made of cardiomyocytes and fibroblasts to characterize the response to cardiac injury in this model (no proliferation, rather fibrotic response).
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
paper: journals.biologists.com/dmm/article/...
movie: Movie 1 from the paper
Member publication alert:
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity
www.nature.com/articles/s44...
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity
www.nature.com/articles/s44...
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity - Nature Cardiovascular Research
Minerath et al. show that cardiomyocyte-derived TGFβ orchestrates a developmental signaling network that is essential for heart maturation. By communicating with non-myocytes, TGFβ promotes cardiomyoc...
www.nature.com
October 25, 2026 at 3:56 PM
Member publication alert:
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity
www.nature.com/articles/s44...
Cardiomyocyte-expressed TGFβ programs early heart maturation and adult myocyte identity
www.nature.com/articles/s44...
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
October 26, 2026 at 2:47 AM
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
Online now: AI-guided discovery and expansion of the human bile acid landscape
AI-guided discovery and expansion of the human bile acid landscape
Yang et al. develop MetLLM, a transformer-based model that learns bile acid structural modification patterns, and MetSpace, an AI-guided chemical-space resource of 3,900 prioritized candidates. Integrated with LC-HRMS/MS, this framework expands bile acid discovery in human feces and identifies MS2141, which modulates M2-linked Gi/o signaling and cardiomyocyte electrophysiology.
dlvr.it
October 28, 2026 at 12:40 PM
Online now: AI-guided discovery and expansion of the human bile acid landscape
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
October 26, 2026 at 5:00 AM
Cardiomyocyte Identity Crisis Without Regenerative Re-entry: A Multi-Scale Atlas of Incomplete Dedifferentiation and Intercellular Communication Rewiring in the Infarcted Human Heart #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
https://www.biorxiv.org/content/10.64898/2026.10.20.760578v1
Mcu upregulation triggers mitochondrial oxidative stress and cardiomyocyte injury after myocardial infarction yet is suppressed by Fto and Ythdf2 in an m6A-dependent manner
Free radical biology & medicine · Chen et al.
doi.org/10.1016/j.freeradbiomed.2026.10.026
#RNAsky #RNAmods
Free radical biology & medicine · Chen et al.
doi.org/10.1016/j.freeradbiomed.2026.10.026
#RNAsky #RNAmods
Mcu upregulation triggers mitochondrial oxidative stress and cardiomyocyte injury after myocardial infarction yet is suppressed by Fto and Ythdf2 in an m6A-dependent manner
Free radical biology & medicine · Chen R, Wang X, Qin L, Liu Z, Yu C, Li X, Zhang Z, Yang F, Zhang H, Lan H, Luan X, Xu X, Qu C, Li B, Li G, Chu XM.
doi.org
October 22, 2026 at 11:49 PM
Mcu upregulation triggers mitochondrial oxidative stress and cardiomyocyte injury after myocardial infarction yet is suppressed by Fto and Ythdf2 in an m6A-dependent manner
Free radical biology & medicine · Chen et al.
doi.org/10.1016/j.freeradbiomed.2026.10.026
#RNAsky #RNAmods
Free radical biology & medicine · Chen et al.
doi.org/10.1016/j.freeradbiomed.2026.10.026
#RNAsky #RNAmods