Purpose of the review Neurocysticercosis (NCC) has been well recognized as a leading cause of epilepsy. More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocercia...

In the mature brain, the extracellular matrix (ECM) molecules derived from neurons and glia accumulate in spatially distinct extracellular compartments, incl...

【Exp Neurol】<AbstractText>Temporal lobe epilepsy (TLE) is linked to progressive alterations in brain network dynamics, leading ...

The contribution of non-synaptic mechanisms to the seizure susceptibility of rat CA1 hippocampal pyramidal cells was examined in vitro by testing the effects of osmolality on synchronous neuronal activity, using solutions which blocked chemical synaptic transmission both pre- and post-synaptically. …

BACKGROUND AND PURPOSE: Tuberous sclerosis complex (TSC) is a multisystemic genetic disorder whose main neuropathologic features include cortical and subcortical tubers, believed to be the source of epileptogenesis. The main purpose of this study was to disclose the performance of 7T and conventional MRI in classifying and counting tubers, in 30 subjects with clinically confirmed TSC and TSC1 and TSC2 molecular analysis. MATERIALS AND METHODS: In subjects with TSC, performance of 7T and conventional brain MRI in counting and recognizing tuber types were analyzed and compared. Additionally, epilepsy status and molecular analysis data were evaluated and their relationship with tuber burden analyzed. RESULTS: On average, 7T MRI detected 28 more tubers than 3T MRI and 32 more tubers than 1.5T MRI. 7T MRI detected significantly more type C tubers than 3T MRI ( P < .001) and 1.5T MRI ( P = .01). On 7T MRI, the group with active epilepsy had statistically significant higher total tuber counting than the groups with controlled epilepsy ( P = .03) or without epilepsy ( P = .03). There was no statistical difference among the 3 groups on conventional MRI. On 7T MRI, TSC2 subjects had significantly higher total tuber counts than those with TSC1 ( P = .004), and the same was observed on conventional MRI ( P = .001). On 7T MRI, subjects with TSC1 also had significantly higher tuber counts than those with no identified mutation ( P < .001), which was not observed on conventional MRI ( P = .07). CONCLUSIONS: The capability of 7T MRI in detecting more tubers than conventional MRI may contribute to the understanding of the complexity of brain involvement in TSC, may help to delineate more precisely possible epileptogenic tubers, and to recognize lesions like tuber C, with a known link to epilepsy severity. Higher tubers count in the active epilepsy group and a significant correlation with TSC2 variants demonstrates the role of tuber load in epileptogenicity. ASM : antiseizure medication NMI : no mutation identified QSM : quantitative susceptibility mapping TSC : tuberous sclerosis complex

Abstract. Epilepsy is a neural disorder characterized by recurrent seizures. Bang-sensitive Drosophila represent an important model for studying epilepsy a

The mechanism of epileptogenesis in Alzheimer’s disease (AD) remains poorly understood, though growing evidence indicates shared molecular mechanisms between epilepsy (EP) and AD. This study aims to r...

Whether and how gamma entrainment using sensory stimuli (GENUS) has a role in antiepileptogenesis is not fully understood. Here authors show that GENUS reduces seizure susceptibility in male mice. The...

Purpose of Review This review examines the role of different viral infections in epileptogenesis, with a focus on Herpesviruses such as Human Herpesvirus 6 (HHV-6) and Epstein Barr Virus (EBV), Flaviv...

Purpose of Review This review examines the role of different viral infections in epileptogenesis, with a focus on Herpesviruses such as Human Herpesvirus 6 (HHV-6) and Epstein Barr Virus (EBV), Flaviv...

Purpose of Review This review examines the role of different viral infections in epileptogenesis, with a focus on Herpesviruses such as Human Herpesvirus 6 (HHV-6) and Epstein Barr Virus (EBV), Flaviv...

Phagocytes maintain homeostasis in a healthy brain. Upon injury, they are essential for repairing damaged tissue, recruiting other immune cells, and releasin...

Purpose of Review This review examines the role of different viral infections in epileptogenesis, with a focus on Herpesviruses such as Human Herpesvirus 6 (HHV-6) and Epstein Barr Virus (EBV), Flaviv...