Reposting some old pictures for #fluorescencefriday! A pyramidal neuron (violet) & a microglial cell (cyan) labelled with DiI from the prefrontal cortex of a rat brain.
April 11, 2025 at 8:44 AM
Reposting some old pictures for #fluorescencefriday! A pyramidal neuron (violet) & a microglial cell (cyan) labelled with DiI from the prefrontal cortex of a rat brain.
Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
Lipids: Emerging Players of Microglial Biology
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...
onlinelibrary.wiley.com
December 17, 2024 at 2:46 PM
Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
Spatial proteomics of Alzheimer’s disease-specific human microglial states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial proteomics of Alzheimer’s disease-specific human microglial states - Nature Immunology
In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.
www.nature.com
July 26, 2025 at 8:53 PM
Spatial proteomics of Alzheimer’s disease-specific human microglial states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 3, 2025 at 4:18 PM
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.nature.com/articles/s41...
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Zhaoquan Wang et al.
@nature.com 🧪
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Zhaoquan Wang et al.
@nature.com 🧪
Early life high fructose impairs microglial phagocytosis and neurodevelopment - Nature
Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in adolescence.
www.nature.com
June 14, 2025 at 11:28 PM
www.nature.com/articles/s41...
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Zhaoquan Wang et al.
@nature.com 🧪
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Zhaoquan Wang et al.
@nature.com 🧪
Nature research paper: Early life high fructose impairs microglial phagocytosis and neurodevelopment
https://go.nature.com/3HGv4na
https://go.nature.com/3HGv4na
Early life high fructose impairs microglial phagocytosis and neurodevelopment - Nature
Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in adolescence.
go.nature.com
June 13, 2025 at 3:23 PM
Nature research paper: Early life high fructose impairs microglial phagocytosis and neurodevelopment
https://go.nature.com/3HGv4na
https://go.nature.com/3HGv4na
1) Heya! For anyone interested in microglia and neuroimmunology, please feel free to check out my recent publication: rdcu.be/eeEbB. In this study, we explored the cell-cell signaling that regulates microglial specification and homeostasis in the developing brain! (1/21)
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity
Nature Communications - Microglial states are dynamically regulated during development and disease. Here, the authors show that these changes are mediated by cell autonomous TGF-β signaling in...
rdcu.be
June 10, 2025 at 4:46 AM
1) Heya! For anyone interested in microglia and neuroimmunology, please feel free to check out my recent publication: rdcu.be/eeEbB. In this study, we explored the cell-cell signaling that regulates microglial specification and homeostasis in the developing brain! (1/21)
congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function.
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
December 17, 2024 at 2:17 PM
congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function.
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Propagation of #neuronal micronuclei regulates #microglial characteristics.
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may a...
www.nature.com
January 17, 2025 at 4:35 PM
Propagation of #neuronal micronuclei regulates #microglial characteristics.
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
Another great mechanism regulating #neuroimmune interactions!
#neuroskyence #neuroscience
www.nature.com/articles/s41...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 3, 2025 at 5:51 PM
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @roisinmcmanus.bsky.social
Microglial plasticity governed by state-specific enhancer landscapes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglial plasticity governed by state-specific enhancer landscapes
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets ...
www.biorxiv.org
February 3, 2025 at 9:25 PM
Microglial plasticity governed by state-specific enhancer landscapes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Abnormal lipid metabolism in Alzheimer's disease (AD) was first documented by Alois Alzheimer in his
www.biorxiv.org
November 19, 2024 at 12:08 PM
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience
The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...
www.nature.com
May 28, 2025 at 11:39 AM
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuronal micronuclei transfer to #microglia, altering microglial morphology and gene expression during the postnatal period in mice 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Propagation of neuronal micronuclei regulates microglial characteristics - Nature Neuroscience
Neuronal micronuclei are transferred to microglia during the early postnatal period, which leads to altered microglial morphology and transcriptomic signatures, suggesting that these micronuclei may act as mediators that control microglial characteristics.
www.nature.com
January 21, 2025 at 3:07 PM
Neuronal micronuclei transfer to #microglia, altering microglial morphology and gene expression during the postnatal period in mice 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglial plasticity governed by state-specific enhancer landscapes
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets ...
www.biorxiv.org
February 4, 2025 at 2:38 AM
PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
December 18, 2024 at 10:35 PM
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine
Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.
www.nature.com
March 6, 2025 at 11:31 PM
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 4, 2025 at 6:56 AM
Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Therapeutic genetic restoration through allogeneic brain microglia replacement - Nature
Nature - Therapeutic genetic restoration through allogeneic brain microglia replacement
www.nature.com
August 6, 2025 at 3:33 PM
An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...