What happens when MED14 fails to properly coordinate gene expression during #embryogenesis?
This study links a #MED14 mutation to VACTERL-like defects by impairing gene expression and multi-organ development. #RNApolymeraseII
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study links a #MED14 mutation to VACTERL-like defects by impairing gene expression and multi-organ development. #RNApolymeraseII
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 30, 2026 at 10:30 PM
What happens when MED14 fails to properly coordinate gene expression during #embryogenesis?
This study links a #MED14 mutation to VACTERL-like defects by impairing gene expression and multi-organ development. #RNApolymeraseII
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study links a #MED14 mutation to VACTERL-like defects by impairing gene expression and multi-organ development. #RNApolymeraseII
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
At #SEDB2026 we're excited to welcome Francisca Martínez Real @cabd-upo-csic.bsky.social Her research explores how gene regulatory networks and chromatin architecture shape early animal development, revealing how non-coding genomic elements coordinate gene expression during embryogenesis. #DevBio
October 27, 2026 at 9:50 AM
At #SEDB2026 we're excited to welcome Francisca Martínez Real @cabd-upo-csic.bsky.social Her research explores how gene regulatory networks and chromatin architecture shape early animal development, revealing how non-coding genomic elements coordinate gene expression during embryogenesis. #DevBio
CURE set up in General Botany #ECSU. Undergrads cut sterile corn 🌽 leaves and placed on two different plant tissue culture media 🍬🧫 for somatic embryo formation. Also did an expt. on shoot regeneration using sterile petunia leaves🍃. #ECSUVikingsScience #undergradsinthelab
October 28, 2026 at 6:48 PM
CURE set up in General Botany #ECSU. Undergrads cut sterile corn 🌽 leaves and placed on two different plant tissue culture media 🍬🧫 for somatic embryo formation. Also did an expt. on shoot regeneration using sterile petunia leaves🍃. #ECSUVikingsScience #undergradsinthelab
The authors included RRIDs in their in eLife paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #accelerateopenscience
TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis
Read the full paper: TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis
doi.org
October 30, 2026 at 7:02 AM
The authors included RRIDs in their in eLife paper! We value the author's support of reproducibility. #reproducibility #OpenResearch #accelerateopenscience
Our next guest speaker webinar is happening on Friday, 6th November, 15:30-16:30pm GMT. Jacob (Yaqub) Hanna
"Synthetic Ex Utero Embryogenesis: from Naive Pluripotent Cells to bona fide Embryo Models" Please follow this link to join: www.qmul.ac.uk/epigenetics/...
"Synthetic Ex Utero Embryogenesis: from Naive Pluripotent Cells to bona fide Embryo Models" Please follow this link to join: www.qmul.ac.uk/epigenetics/...
October 28, 2026 at 11:05 AM
Our next guest speaker webinar is happening on Friday, 6th November, 15:30-16:30pm GMT. Jacob (Yaqub) Hanna
"Synthetic Ex Utero Embryogenesis: from Naive Pluripotent Cells to bona fide Embryo Models" Please follow this link to join: www.qmul.ac.uk/epigenetics/...
"Synthetic Ex Utero Embryogenesis: from Naive Pluripotent Cells to bona fide Embryo Models" Please follow this link to join: www.qmul.ac.uk/epigenetics/...
Primate organogenetic embryoids derived from cynomolgus totipotent blastomere-like stem cells (cTBLCs) successfully model early embryogenesis stages, revealing key totipotent features akin to zygote/2-4 cell… PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9
https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9
No description available
www.cell.com
November 1, 2026 at 1:00 PM
Primate organogenetic embryoids derived from cynomolgus totipotent blastomere-like stem cells (cTBLCs) successfully model early embryogenesis stages, revealing key totipotent features akin to zygote/2-4 cell… PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9
DNA 'flight recorder' traces embryonic development cell by cell
Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis🧪
www.cell.com/cell/fulltex...
This offers one of the most detailed views yet of how a mammal is built, cell by cell.
Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis🧪
www.cell.com/cell/fulltex...
This offers one of the most detailed views yet of how a mammal is built, cell by cell.
October 26, 2026 at 4:30 PM
DNA 'flight recorder' traces embryonic development cell by cell
Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis🧪
www.cell.com/cell/fulltex...
This offers one of the most detailed views yet of how a mammal is built, cell by cell.
Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis🧪
www.cell.com/cell/fulltex...
This offers one of the most detailed views yet of how a mammal is built, cell by cell.
- "On how Polycomb domains are established during early embryogenesis".
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
Epigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic...
buff.ly
October 24, 2026 at 8:03 AM
- "On how Polycomb domains are established during early embryogenesis".
Primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) effectively model embryogenesis, revealing key totipotent traits akin to zygotes and early blastomeres. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9
No description available
www.cell.com
October 25, 2026 at 6:00 PM
Primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) effectively model embryogenesis, revealing key totipotent traits akin to zygotes and early blastomeres. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky 🧪
(archive: 2024) Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound Due to Irregular Mechano-Transduction: Abstract: The microcirculation of mammals is an autoregulated and complex synchronised system according to the current demand… #windenergy
(archive: 2024) Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound Due to Irregular Mechano-Transduction
Abstract: The microcirculation of mammals is an autoregulated and complex synchronised system according to the current demand for nutrients and oxygen. The undisturbed course of vital functions such as of growth, blood pressure regulation, inflammatory sequence and embryogenesis is bound to endothelial integrity. The sensible vasomotion is particularly dependent on it. Mechano-transduction signalling networks play a critical role in vital cellular processes and are the decisive physiological mechanism for an adequate nitric oxide release, the main pathway responsible for the . . .
www.wind-watch.org
October 30, 2026 at 11:44 AM
(archive: 2024) Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound Due to Irregular Mechano-Transduction: Abstract: The microcirculation of mammals is an autoregulated and complex synchronised system according to the current demand… #windenergy
Nature research paper: Modelling mouse embryogenesis from chemically induced totipotent stem cells
go.nature.com/4hOKaqh
go.nature.com/4hOKaqh
Modelling mouse embryogenesis from chemically induced totipotent stem cells - Nature
A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation, haematopoiesis and early organogenesis.
go.nature.com
October 21, 2026 at 8:51 AM
Nature research paper: Modelling mouse embryogenesis from chemically induced totipotent stem cells
go.nature.com/4hOKaqh
go.nature.com/4hOKaqh
Evolutionary transition in accessible chromatin landscapes during vertebrate embryogenesis https://www.biorxiv.org/cgi/content/short/481309v1 #EvoDevo
October 21, 2026 at 1:00 PM
Evolutionary transition in accessible chromatin landscapes during vertebrate embryogenesis https://www.biorxiv.org/cgi/content/short/481309v1 #EvoDevo
Our new @CellStemCell paper explores the missing half: "Subtractive Tissue Engineering" is what we named it. 🧵#development #celldeath #syntheticbiology #systemsbiology #embryogenesis #organoids #NAMs #human #stemcell
October 22, 2026 at 9:24 PM
Our new @CellStemCell paper explores the missing half: "Subtractive Tissue Engineering" is what we named it. 🧵#development #celldeath #syntheticbiology #systemsbiology #embryogenesis #organoids #NAMs #human #stemcell
Attending #ASHG #ASHG26 🧬?
From my lab, tomorrow at 11am, a stellar 🌟 PhD student Kyra will be talking about the mysteries of gene regulation in the earliest human embryogenesis👶 up to 4 wks when no available fetal data existed, and how it's related to common and rare developmental diseases!
From my lab, tomorrow at 11am, a stellar 🌟 PhD student Kyra will be talking about the mysteries of gene regulation in the earliest human embryogenesis👶 up to 4 wks when no available fetal data existed, and how it's related to common and rare developmental diseases!
October 21, 2026 at 3:02 PM
new paper: "Neural peer pressure: intercellular dynamics and emergent phenotypes in the mosaic Rett syndrome brain" https://doi.org/10.1186/s12964-026-02987-w
"During female embryogenesis, each cell randomly inactivates either the maternal or paternal X […]
[Original post on social.edu.nl]
"During female embryogenesis, each cell randomly inactivates either the maternal or paternal X […]
[Original post on social.edu.nl]
October 25, 2026 at 7:20 AM
new paper: "Neural peer pressure: intercellular dynamics and emergent phenotypes in the mosaic Rett syndrome brain" https://doi.org/10.1186/s12964-026-02987-w
"During female embryogenesis, each cell randomly inactivates either the maternal or paternal X […]
[Original post on social.edu.nl]
"During female embryogenesis, each cell randomly inactivates either the maternal or paternal X […]
[Original post on social.edu.nl]
• B cells co-opt imprinted genes involved in embryogenesis: The “primitive” lymphoid progenitors engage an evolutionarily conserved developmental program enriched for imprinted genes associated with organogenesis (H19, DLK1, MEG3, KCNQ1OT1, and CDKN1C, as well as early-life regulators IGF2BP1/3).
October 21, 2026 at 4:11 PM
• B cells co-opt imprinted genes involved in embryogenesis: The “primitive” lymphoid progenitors engage an evolutionarily conserved developmental program enriched for imprinted genes associated with organogenesis (H19, DLK1, MEG3, KCNQ1OT1, and CDKN1C, as well as early-life regulators IGF2BP1/3).
⭐ 📖 Paper of the Month: Nov
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function ➡️ doi.org/10.2337/db26-0227
Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function ➡️ doi.org/10.2337/db26-0227
Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
October 21, 2026 at 7:15 PM
⭐ 📖 Paper of the Month: Nov
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function ➡️ doi.org/10.2337/db26-0227
Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function ➡️ doi.org/10.2337/db26-0227
Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
Having terrific grad students when you start the lab can really power your success. It's fun to see these two papers from my first two grad students continuing to garner citations 30 years later, going back and forth in which is most cited. My new postbacs picked these for journal club last week
October 19, 2026 at 2:11 PM
Having terrific grad students when you start the lab can really power your success. It's fun to see these two papers from my first two grad students continuing to garner citations 30 years later, going back and forth in which is most cited. My new postbacs picked these for journal club last week
化学的に誘導した全能性様幹細胞から、胚と胚体外組織を含むマウス胚モデルを構築。胚モデルは原腸形成、体軸形成、造血、初期器官形成まで進み、培養を延長すると機能的な心臓組織も形成された。哺乳類の初期発生を研究する新たな実験系となる。ただし、発生が進むにつれてモデルの発生効率が低下し、自然胚とは異なる構造が出るらしく、限界はありそう。
Modelling mouse embryogenesis from chemically induced totipotent stem cells
www.nature.com/articles/s41...
Modelling mouse embryogenesis from chemically induced totipotent stem cells
www.nature.com/articles/s41...
Modelling mouse embryogenesis from chemically induced totipotent stem cells - Nature
A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation, haematopoiesis and ea...
www.nature.com
October 19, 2026 at 11:59 AM
化学的に誘導した全能性様幹細胞から、胚と胚体外組織を含むマウス胚モデルを構築。胚モデルは原腸形成、体軸形成、造血、初期器官形成まで進み、培養を延長すると機能的な心臓組織も形成された。哺乳類の初期発生を研究する新たな実験系となる。ただし、発生が進むにつれてモデルの発生効率が低下し、自然胚とは異なる構造が出るらしく、限界はありそう。
Modelling mouse embryogenesis from chemically induced totipotent stem cells
www.nature.com/articles/s41...
Modelling mouse embryogenesis from chemically induced totipotent stem cells
www.nature.com/articles/s41...
Plant embryogenesis from zygotic genome activation to seed maturation: Comparative mechanisms and engineering opportunities https://pubmed.ncbi.nlm.nih.gov/42880594/ #EvoDevo
October 16, 2026 at 1:00 PM
Plant embryogenesis from zygotic genome activation to seed maturation: Comparative mechanisms and engineering opportunities https://pubmed.ncbi.nlm.nih.gov/42880594/ #EvoDevo
Our latest paper is now out in @dev-journal.bsky.social. We investigated how Notch signalling, implicated in Hirschsprung disease (HSCR) regulates human enteric nervous system (ENS) development (1/n): journals.biologists.com/dev/article/...
Notch signalling governs human enteric nervous system progenitor dynamics
The enteric nervous system (ENS) is the main branch of the peripheral nervous system that innervates the gastrointestinal tract controlling vital functions. It arises during embryogenesis via migratio...
journals.biologists.com
October 16, 2026 at 9:21 AM
Our latest paper is now out in @dev-journal.bsky.social. We investigated how Notch signalling, implicated in Hirschsprung disease (HSCR) regulates human enteric nervous system (ENS) development (1/n): journals.biologists.com/dev/article/...
Peptide phytosulfokine-α improves the efficiency of somatic embryogenesis in hybrid sweetgum leaves | Journal of Forestry Research | Springer Nature Link link.springer.com/article/10.1...
@forestryjfr.bsky.social
@forestryjfr.bsky.social
Peptide phytosulfokine-α improves the efficiency of somatic embryogenesis in hybrid sweetgum leaves - Journal of Forestry Research
Somatic embryogenesis (SE) from vegetative organs remains a major bottleneck for the clonal propagation of forest trees, and conventional plant-hormone treatments are insufficient for establishing eff...
link.springer.com
October 15, 2026 at 1:35 PM
Peptide phytosulfokine-α improves the efficiency of somatic embryogenesis in hybrid sweetgum leaves | Journal of Forestry Research | Springer Nature Link link.springer.com/article/10.1...
@forestryjfr.bsky.social
@forestryjfr.bsky.social
Successful generation of primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveals key totipotent features, advancing insights into early embryogenesis. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9
No description available
www.cell.com
October 16, 2026 at 2:00 AM
Successful generation of primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveals key totipotent features, advancing insights into early embryogenesis. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky 🧪
