New study analyzes 470 angiosperm genomes, revealing 132 ancient WGD events clustering during environmental upheaval—showcasing polyploidy as a pivotal evolutionary force. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1
No description available
www.cell.com
November 3, 2026 at 5:00 AM
CANVAS uses AI to analyze 18 million+ cells in H&E histopathology, revealing tumor microenvironment's influence on progression and therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8
No description available
www.cell.com
November 4, 2026 at 2:00 AM
Study reveals that somatic mutations in cancer driver genes are enriched in Alzheimer’s brains, particularly in microglia-like cells, indicating links to neuroinflammation (n=311). PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7
No description available
www.cell.com
November 4, 2026 at 1:00 PM
Study reveals that somatic mutations in cancer driver genes are enriched in Alzheimer’s brains, particularly in microglia-like cells, indicating links to neuroinflammation (n=311). PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪
Wang et al. unveil RegVelo, integrating gene regulatory networks with RNA velocity analysis, pinpointing candidate regulators that steer cell fate decisions. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600588X
No description available
www.cell.com
November 4, 2026 at 12:00 PM
Discovery of Galvanin (TMEM154) reveals its crucial role in electric-field-guided migration of immune/epithelial cells, essential for rapid responses to tissue injury. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7
No description available
www.cell.com
November 4, 2026 at 4:00 AM
A new study reveals a LLM-based framework that accelerates CAR T target discovery, identifying GPNMB as a promising target across melanoma, leukemia, and colorectal cancer. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5
No description available
www.cell.com
November 2, 2026 at 9:00 PM
A study reveals shared neural geometries in the hippocampus of bilinguals, with "cross-language neurons" showing correlated responses to equivalent words in English and Spanish. PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9
No description available
www.cell.com
November 2, 2026 at 4:00 AM
Study reveals hippocampal neurons in bilinguals share "cross-language" responses for similar concepts across English and Spanish, indicating shared semantic maps. PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9
No description available
www.cell.com
November 3, 2026 at 5:00 PM
New research shows ~50% of fertilized human eggs arrest in pre-implantation due to error-prone 2nd mitotic divisions. PLK4 inhibition can reduce centriole overduplication! PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
November 2, 2026 at 10:00 PM
It's this one
bsky.app/profile/ashg...
bsky.app/profile/ashg...
The difference between sub Jayce and sub Viktor in my mind is that sub Jayce's kinks boil down to "what if I was stupid but you loved me anyway" and sub Viktor's kinks boil down to "what if someone I loved had control over my body"
October 28, 2026 at 7:53 PM
It's this one
bsky.app/profile/ashg...
bsky.app/profile/ashg...
New D&D-seq method reveals single-cell DNA-protein interactions, capturing transient TF binding insights. Key to understanding gene regulation dynamics! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8
No description available
www.cell.com
November 3, 2026 at 11:00 AM
🌟Breaking: Expert consensus on imaging for cutaneous squamous cell carcinoma (CSCC)! New staging & surveillance guidelines to standardize practice across settings. #DermOncology PMID:42418212, JAMA Dermatol 2026 @Stanford https://doi.org/10.1001/jamadermatol.2026.2163 #Medsky #Pharmsky #RNA #ASHG 🧪
https://doi.org/10.1001/jamadermatol.2026.2163
No description available
doi.org
November 3, 2026 at 2:00 AM
🌟Breaking: Expert consensus on imaging for cutaneous squamous cell carcinoma (CSCC)! New staging & surveillance guidelines to standardize practice across settings. #DermOncology PMID:42418212, JAMA Dermatol 2026 @Stanford https://doi.org/10.1001/jamadermatol.2026.2163 #Medsky #Pharmsky #RNA #ASHG 🧪
Endogenous ADARs can be harnessed with engineered arRNAs for safe RNA editing. LEAPER 3.0 utilizes AlphaFold 3 for improved design, boosting efficiency and precision in RNA edits. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3
No description available
www.cell.com
November 4, 2026 at 5:00 PM
New insights reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cell fate & disease. Fascinating! PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7
No description available
www.cell.com
November 4, 2026 at 8:00 AM
Exploring SRD: Beyond dopamine! Revealing multiple pathways causing diverse symptoms. Elevate understanding! 🚀🔍 PMID:42418174, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1684 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1001/jamapsychiatry.2026.1684
No description available
doi.org
November 3, 2026 at 3:00 AM
AI-driven discovery of GPNMB CAR T cells shows promise as a multi-cancer therapy, optimizing targets through single-cell RNA sequencing analysis, enhancing therapeutic efficacy. PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3
No description available
www.cell.com
November 2, 2026 at 2:00 AM
New CRISPR screens in primary human CD4+ T cells reveal 40+ pro- and anti-HIV host factors, uncovering diverse antiviral mechanisms. Exciting insights ahead! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600382X
No description available
www.cell.com
November 4, 2026 at 9:00 AM
A novel single-cell tech, D&D-seq, maps transient DNA-protein interactions, revealing how TFs shape gene expression via chromatin dynamics. Key insights await! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8
No description available
www.cell.com
November 1, 2026 at 11:00 PM
Study of 469 neurons from C9ORF72 ALS, C9ORF72 FTD, and AD reveals increased somatic mutations, linking TOP1-mediated genomic damage across neurodegenerative disorders. PMID:42385702, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2
No description available
www.cell.com
November 2, 2026 at 11:00 PM
New SC2r-CoVs clades found in Thai horseshoe bats reveal intriguing virological traits, including human ACE2 receptor binding. This highlights ongoing risk of zoonotic spillover! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
November 4, 2026 at 9:00 PM
New SC2r-CoVs clades found in Thai horseshoe bats reveal intriguing virological traits, including human ACE2 receptor binding. This highlights ongoing risk of zoonotic spillover! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Paleoproteomic analysis of dental enamel from 20 Homo naledi individuals shows no male markers, suggesting a homogenous, possibly single-sex sample from Rising Star cave. PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6
No description available
www.cell.com
November 2, 2026 at 6:00 PM
Study shows heat stress in mice triggers metabolic dysfunction via skin-derived KLK14, impacting hypothalamic astrocytes. 1 exposure sets stage for 2nd risk! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6
No description available
www.cell.com
November 4, 2026 at 4:00 PM
New CRISPR prime editing targets histone H3, allowing precise changes to Lys sites. PMID:42420522, Nat Genet 2026, @NatureGenet @OTSociety @NAR_Open https://doi.org/10.1038/s41588-026-02675-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing | Nature Genetics
Histone post-translational modifications are fundamental to genome regulation, yet dissecting the functions of individual histone marks in mammals remains challenging due to the presence of multiple histone gene copies. Here we develop a high-throughput clustered regularly interspaced short palindromic repeats (CRISPR) prime editing platform enabling precise, reversible and combinatorial mutagenesis of canonical and noncanonical histone H3 genes within their native genomic context. Using systematic lysine-to-arginine substitutions benchmarked against synonymous controls, we identify key residues, including H3K4, H3K9, H3K14, H3K18 and H3K79, whose mutation compromises fitness in mouse embryonic stem cells. We further show that H3K56, linked to genome stability in yeast and Drosophila, has a conserved role in mammalian cells. Through analysis of selected double mutants, we uncover functional crosstalk across residues, with combinations such as H3K27R + H3K36R impairing stem cell self-re
doi.org
November 4, 2026 at 1:00 AM
The cGAS-STING pathway detects dsDNA, influencing immunity and tissue homeostasis. Key roles in antiviral defense, tumor immunity, and inflammation described. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1
No description available
www.cell.com
November 1, 2026 at 9:00 PM