New study analyzes 470 angiosperm genomes, revealing 132 ancient WGD events clustering during environmental upheaval—showcasing polyploidy as a pivotal evolutionary force. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1
No description available
www.cell.com
November 3, 2026 at 5:00 AM
CANVAS uses AI to analyze 18 million+ cells in H&E histopathology, revealing tumor microenvironment's influence on progression and therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8
No description available
www.cell.com
November 4, 2026 at 2:00 AM
Discovery of Galvanin (TMEM154) reveals its crucial role in electric-field-guided migration of immune/epithelial cells, essential for rapid responses to tissue injury. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7
No description available
www.cell.com
November 4, 2026 at 4:00 AM
Wang et al. unveil RegVelo, integrating gene regulatory networks with RNA velocity analysis, pinpointing candidate regulators that steer cell fate decisions. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600588X
No description available
www.cell.com
November 4, 2026 at 12:00 PM
A new study reveals a LLM-based framework that accelerates CAR T target discovery, identifying GPNMB as a promising target across melanoma, leukemia, and colorectal cancer. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5
No description available
www.cell.com
November 2, 2026 at 9:00 PM
New research shows ~50% of fertilized human eggs arrest in pre-implantation due to error-prone 2nd mitotic divisions. PLK4 inhibition can reduce centriole overduplication! PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
www.cell.com
November 2, 2026 at 10:00 PM
Study reveals hippocampal neurons in bilinguals share "cross-language" responses for similar concepts across English and Spanish, indicating shared semantic maps. PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9
No description available
www.cell.com
November 3, 2026 at 5:00 PM
New D&D-seq method reveals single-cell DNA-protein interactions, capturing transient TF binding insights. Key to understanding gene regulation dynamics! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8
No description available
www.cell.com
November 3, 2026 at 11:00 AM
Exploring SRD: Beyond dopamine! Revealing multiple pathways causing diverse symptoms. Elevate understanding! 🚀🔍 PMID:42418174, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1684 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1001/jamapsychiatry.2026.1684
No description available
doi.org
November 3, 2026 at 3:00 AM
New insights reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cell fate & disease. Fascinating! PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7
No description available
www.cell.com
November 4, 2026 at 8:00 AM
Study of 469 neurons from C9ORF72 ALS, C9ORF72 FTD, and AD reveals increased somatic mutations, linking TOP1-mediated genomic damage across neurodegenerative disorders. PMID:42385702, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2
No description available
www.cell.com
November 2, 2026 at 11:00 PM
A novel single-cell tech, D&D-seq, maps transient DNA-protein interactions, revealing how TFs shape gene expression via chromatin dynamics. Key insights await! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8
No description available
www.cell.com
November 1, 2026 at 11:00 PM
New CRISPR screens in primary human CD4+ T cells reveal 40+ pro- and anti-HIV host factors, uncovering diverse antiviral mechanisms. Exciting insights ahead! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600382X
No description available
www.cell.com
November 4, 2026 at 9:00 AM
Paleoproteomic analysis of dental enamel from 20 Homo naledi individuals shows no male markers, suggesting a homogenous, possibly single-sex sample from Rising Star cave. PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6
No description available
www.cell.com
November 2, 2026 at 6:00 PM
The cGAS-STING pathway detects dsDNA, influencing immunity and tissue homeostasis. Key roles in antiviral defense, tumor immunity, and inflammation described. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1
No description available
www.cell.com
November 1, 2026 at 9:00 PM
Study shows heat stress in mice triggers metabolic dysfunction via skin-derived KLK14, impacting hypothalamic astrocytes. 1 exposure sets stage for 2nd risk! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6
No description available
www.cell.com
November 4, 2026 at 4:00 PM
New CRISPR prime editing targets histone H3, allowing precise changes to Lys sites. PMID:42420522, Nat Genet 2026, @NatureGenet @OTSociety @NAR_Open https://doi.org/10.1038/s41588-026-02675-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing | Nature Genetics
Histone post-translational modifications are fundamental to genome regulation, yet dissecting the functions of individual histone marks in mammals remains challenging due to the presence of multiple histone gene copies. Here we develop a high-throughput clustered regularly interspaced short palindromic repeats (CRISPR) prime editing platform enabling precise, reversible and combinatorial mutagenesis of canonical and noncanonical histone H3 genes within their native genomic context. Using systematic lysine-to-arginine substitutions benchmarked against synonymous controls, we identify key residues, including H3K4, H3K9, H3K14, H3K18 and H3K79, whose mutation compromises fitness in mouse embryonic stem cells. We further show that H3K56, linked to genome stability in yeast and Drosophila, has a conserved role in mammalian cells. Through analysis of selected double mutants, we uncover functional crosstalk across residues, with combinations such as H3K27R + H3K36R impairing stem cell self-re
doi.org
November 4, 2026 at 1:00 AM
A novel viral ORFeome library with ~12,000 vORFs from 513 species reveals hundreds of viral regulators influencing cell growth, MHC I presentation, and interferon signaling. PMID:42392077, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0
No description available
www.cell.com
November 4, 2026 at 2:00 PM
A study found that 3' UTRs of 2,700+ human mRNAs with conserved nucleotides regulate protein activity by co-translationally folding IDRs, enhancing JMJD3 function. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3
No description available
www.cell.com
October 31, 2026 at 4:00 AM
2'3'-cGAMP triggers membrane shearing for broad anti-phage immunity via TM proteins, revealing crucial mechanisms in prokaryotic antiviral strategies. Fascinating insights! PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2
No description available
www.cell.com
November 4, 2026 at 7:00 AM
A groundbreaking study finds TMEM154/Galvanin as a receptor that helps cells sense electric fields, guiding migration toward the cathode. #CellBiology PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0
No description available
www.cell.com
November 1, 2026 at 7:00 AM
A groundbreaking study finds TMEM154/Galvanin as a receptor that helps cells sense electric fields, guiding migration toward the cathode. #CellBiology PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male-specific markers, suggesting a single-sex sample. Fascinating find! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6
No description available
www.cell.com
November 1, 2026 at 4:00 PM
A novel method, VIS-seq, analyzes ~3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell morphology, protein localization, and activity. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6
No description available
www.cell.com
November 1, 2026 at 4:00 AM
A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent against mating and egg-laying in Drosophila, with diallyl disulfide being key! 🧄 PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7
No description available
www.cell.com
October 31, 2026 at 8:00 AM
Two clades of SARS-CoV-2-related coronaviruses co-circulating in Thai horseshoe bats show one binds human ACE2, revealing potential zoonotic risks. Exciting virological insights! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
October 30, 2026 at 8:00 PM
Two clades of SARS-CoV-2-related coronaviruses co-circulating in Thai horseshoe bats show one binds human ACE2, revealing potential zoonotic risks. Exciting virological insights! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪