#ACSL4
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genesndiseases.bsky.social
Why are fatty liver grafts more vulnerable to #transplant-related injury?
Extracellular vesicles deliver #ACSL4, triggering ferroptosis and mitochondrial damage, revealing a potential target to protect #LiverGrafts.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
November 4, 2026 at 3:30 PM
rnamod.bsky.social
Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models

Molecular biology reports · Yıldırım et al.
doi.org/10.1007/s11033-026-13074-1
#RNAsky #RNAmods
Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models
Molecular biology reports · Yıldırım ME, Ayhan B, Çelik H.
doi.org
November 2, 2026 at 12:06 AM
rnamod.bsky.social
Preconditioning induces ischemic tolerance by attenuating ferroptosis: involvement of the m6A-dependent FTO-IGF2BP1/3-ACSL4 regulatory Axis

Neuropharmacology · Zhang et al.
doi.org/10.1016/j.neuropharm.2026.111229
#RNAsky #RNAmods
Preconditioning induces ischemic tolerance by attenuating ferroptosis: involvement of the m6A-dependent FTO-IGF2BP1/3-ACSL4 regulatory Axis
Neuropharmacology · Zhang YP, Zhang LY, Liu XY, Li SC, Wang XY, Li S, Ren XP, Zhou XY, Zhao CS, Zhao CG, Xian XH, Li SQ, Hu YY, Zhang JG, Zh
doi.org
October 24, 2026 at 10:48 PM
rridrobot.bsky.social
RRIDs were included in this in Free Radical Biology and Medicine paper. RRIDs improve reproducibility in scientific research. #reproducibility #STMpublishing #accelerateopenscience
Lycorine ameliorates MASH by targeting ACSL4 to regulate lipid metabolism and inhibit ferroptosis
Read the full paper: Lycorine ameliorates MASH by targeting ACSL4 to regulate lipid metabolism and inhibit ferroptosis
doi.org
October 24, 2026 at 7:00 AM
osteoporosis-nl.bsky.social
Ferro-aging: a potential driver of degenerative bone and joint diseases S Liang et al. Cell Commun Signal 4 Sep 2026 shorturl.at/1zIOX … review ACSL4-associated ferro-aging contributes to the pathogenesis of OP, OA, and IVDD by disrupting local microenvironmental homeostasis
October 23, 2026 at 7:40 AM
ophthalmology.bsky.social
Ophthopedia Update: tRF-Glu-CTC-005 Promotes Pathological Retinal Neovascularization via ACSL4 in Microvascular Endothelial Cells: Publication date: Available online 9 October 2026

Source: Experimental Eye Research

Author(s): Bingyan Li, Junyu Chen, Junye Zhu, Qiuxiang Zhang, Hui Deng, Haipeng…
tRF-Glu-CTC-005 Promotes Pathological Retinal Neovascularization via ACSL4 in Microvascular Endothelial Cells
Publication date: Available online 9 October 2026 Source: Experimental Eye Research Author(s): Bingyan Li, Junyu Chen, Junye Zhu, Qiuxiang Zhang, Hui Deng, Haipeng Wen, Zhixin Wang, Baoye Sun, Jiale Li, Fan Xu, Fen Tang, Shigeo Yoshida, Yedi Zhou
dlvr.it
October 10, 2026 at 12:32 PM
genesndiseases.bsky.social
Could altered fat metabolism be driving #vasculitis?
This study links enhanced fatty acid–acetyl-CoA flux and #ACSL4 activity in monocytes from pediatric #AAV patients to TGF-β and CD48 signaling, revealing new therapeutic targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 9, 2026 at 3:19 PM
rnamod.bsky.social
METTL3 Confers Ischemia/Reperfusion-Caused Myocardial Injury by Triggering Ferroptosis via Regulating the lncRNA SNHG14/miR-195a-5p/ACSL4 Axis

Cardiovascular drugs and therapy · Lai et al.
doi.org/10.1007/s10557-026-07961-9
#RNAsky #RNAmods
METTL3 Confers Ischemia/Reperfusion-Caused Myocardial Injury by Triggering Ferroptosis via Regulating the lncRNA SNHG14/miR-195a-5p/ACSL4 Axis
Cardiovascular drugs and therapy · Lai G, Yang J, Zhao M, Zhu L, Le D, Liu L, Zhang C, Yang F, Wen J, Gui S, Hu Y, Liang Y.
doi.org
October 3, 2026 at 5:11 PM
cp-trendsendomet.bsky.social
Online Now: Ferro-aging: iron–lipid axis in systemic decline #trends #endocrinology #metabolism
Ferro-aging: iron–lipid axis in systemic decline
Ferro-aging links age-associated iron dyshomeostasis to chronic lipid peroxidation and progressive functional decline across human and nonhuman primate tissues. Vitamin C extends beyond its antioxidant activity by directly inhibiting ACSL4, limiting polyunsaturated fatty acid incorporation into membrane phospholipids and thereby reducing lipid peroxidation and ferro-aging-associated phenotypes.
dlvr.it
October 2, 2026 at 7:09 PM
genesndiseases.bsky.social
ZNF750 links lipid metabolism to ferroptosis in #ESCC.
By suppressing FADS1, it regulates #PUFA remodeling, while its loss increases #ferroptosis sensitivity through ACSL4, revealing therapeutic vulnerabilities.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 19, 2026 at 12:13 PM
cp-cellchembiol.bsky.social
Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted delivery
Dual-function PROTAC suppresses ferroptosis and restores neuronal function via brain-targeted delivery
Ma et al. develop a dual-function PROTAC that degrades ACSL4 to reduce PUFA-containing membrane phospholipids while activating the PPARγ antioxidant pathway to enhance cellular antioxidant defense. Brain-targeted delivery of dACSL4 via biodegradable lipid nanoparticles effectively suppresses neuronal ferroptosis, reducing dopaminergic neuron loss and improving motor function in Parkinson’s disease models.
dlvr.it
September 17, 2026 at 8:31 PM
rscpharmaceutics.rsc.org
We're delighted to announce the winner of the RSC Pharmaceutics best poster at #GP2A2026!
Congratulations to Juliette Lafon of Lab LilNCog, LilleNeuro&Chem, France, who presented "Development of novel drug-like ACSL4 inhibitors as anti-ferroptotic agents targeting Parkinson’s disease".
On the picture (left to right) Florence McMarthy (President of GP2A), Billy Brennan (The University of Dublin Trinity College), Juliette Lafoni (LilNCog), Philipp Klahn (LOC, University Gothenburg) and Morten Grötli (LOC, University Gothenburg). All stand in a line, Billy and Juliette hold their certificates.
September 3, 2026 at 7:54 AM
rnamod.bsky.social
ACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Jia et al.
doi.org/10.1002/advs.77401
#RNAsky #RNAmods
ACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m6A Modification to Intervertebral Disc Degeneration
Here, we identify a mechanism by which N6-methyladenosine (m6A) RNA modification contributes to lysosomal membrane permeabilization (LMP) in IVDD.
doi.org
September 2, 2026 at 1:08 PM
cp-cellmetabolism.bsky.social
Online now: Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
(Cell Metabolism 38, 673–693.e1–e17; April 7, 2026)
dlvr.it
August 19, 2026 at 12:40 PM
jia-jintegragri.bsky.social
#ACSL4 is a target for β-hydroxybutyrate-induced increase in fatty acid content and lipid droplet accumulation in #bovine mammary epithelial cells
❇️https://doi.org/10.1016/j.jia.2024.12.004
#AnimalScience @keaipublishing.bsky.social
March 31, 2026 at 7:24 AM
thailandmedical.bsky.social
Thailand medical researchers identify new biomarkers ACSL4, SLC7A11, and CHAC1 for improved Cholangiocarcinoma prognosis

www.thailandmedical.news/news/thailan...
Thailand medical researchers identify new biomarkers ACSL4, SLC7A11, and CHAC1 for improved Cholangiocarcinoma prognosis - Thailand Medical News
www.thailandmedical.news
September 14, 2024 at 2:56 PM
earthcule.bsky.social
www.nature.com/articles/s42...

Good one Tarang.

These findings confirm that exposure to both PS and BaP can disrupt metabolic homeostasis in the kidneys, contributing to kidney dysfunction and cell death.
Bottled water is filled in a compressed bottle.
Activation of gut metabolite ACSL4/LPCAT3 by microplastics in drinking water mediates ferroptosis via gut–kidney axis - Communications Biology
Polystyrene and Benzo[a]pyrene induce ferroptosis in the kidney by disrupting intestinal metabolites, contributing to kidney disfunction.
www.nature.com
April 30, 2025 at 12:54 PM
gracefuluniverse.bsky.social
#sustainability #ecology #neurology #education #publichealth #midwifery

Exposure to the
phthalate plasticizer DEHP
during pregnancy and breastfeeding
causes brain damage in boys

DEHP causes
ACSL4/TFR-mediated hippocampal neuronal ferroptosis
via YAP activation
www.sciencedirect.com/science/arti...
Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: Implication for the neurocognitive disorders in male offspring
Di-(2-ethylhexyl) phthalate (DEHP) is one of the most extensively used phthalate and poses a public health concern. Perinatal exposure to DEHP has bee…
www.sciencedirect.com
June 28, 2025 at 3:01 AM
cp-cell.bsky.social
Now online! Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo
Supramolecular targeting chimeras (SupTACs) are a modular and programmable platform that enables tissue-specific and temporally controlled protein degradation in vivo across multiple animal species. SupTAC-mediated ACSL4 degradation effectively alleviates ferroptosis and pulmonary inflammation in a murine model of acute lung injury.
dlvr.it
January 16, 2026 at 7:52 PM
biorxiv-sysbio.bsky.social
The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD https://www.biorxiv.org/content/10.1101/2024.06.11.598353v1
The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD https://www.biorxiv.org/content/10.1101/2024.06.11.598353v1
Metabolic dysfunction-associated steatotic liver disease is an increasingly prevalent condition, rep
www.biorxiv.org
June 11, 2024 at 8:04 PM
If you are a primate getting old, you might start thinking on taking vitamin C

www.cell.com/cell-metabol...
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
Liu et al. identify that an iron-triggered aging pathway, termed ferro-aging, is orchestrated by ACSL4. Vitamin C directly targets and inhibits ACSL4, thereby blocking ferro-aging. Their further resea...
www.cell.com
March 11, 2026 at 4:46 PM
ordofibonacci.bsky.social
Low-intensity stimulation drives macrophage efferocytosis via ACSL4 lipid remodeling and CCL9-CCR1 signaling for tendon-bone healing
Science Advances
www.science.org/doi/10.1126/...
Low-intensity stimulation drives macrophage efferocytosis via ACSL4 lipid remodeling and CCL9-CCR1 signaling for tendon-bone healing
Low-intensity loading improves tendon-bone healing by helping immune cells clear dying cells.
www.science.org
July 13, 2026 at 4:24 AM
currentmedscience.bsky.social
Huaier aqueous extract alleviates #Gefitinib resistance in #NSCLC via # ACSL4-dependent #Ferroptosis, highlighting a promising strategy to boost #EGFR-TKI efficacy. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #LungCancerResearch #Therapeutics
Huaier Aqueous Extract Combined with Gefitinib Promotes ACSL4-Dependent Ferroptosis and Overcomes Gefitinib Resistance in Non-Small Cell Lung Cancer
July 26, 2026 at 12:15 PM
currentmedscience.bsky.social
This study shows that #Huaier aqueous extract reverses #Gefitinib resistance in #NSCLC by driving #ACSL4 dependent #Ferroptosis, offering a promising strategy to boost #EGFRTKI efficacy. #medsky
To read: doi.org/10.1007/s115...
Huaier Aqueous Extract Combined with Gefitinib Promotes ACSL4-Dependent Ferroptosis and Overcomes Gefitinib Resistance in Non-Small Cell Lung Cancer
May 25, 2026 at 2:30 PM
labmed2025.bsky.social
⚡ A high PUFA/MUFA ratio → more ACSL4-driven lipid peroxidation → T cell ferroptosis.

🔗 doi.org/10.1016/j.lm...
July 11, 2026 at 5:42 PM