#ferroptosis
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hitenmadhani.bsky.social
Too easy:
Ferroptosis (literal death metal)
cbartman.bsky.social Caroline Bartman @cbartman.bsky.social · 6d
Ok what is the most death metal biology term?
Cytokine storm?
Programmed death 1?
Executioner caspase?
Other?
September 25, 2026 at 3:10 AM
olzmannlab.bsky.social
1/ Happy to see this collaborative work w/ Fangzhu Zhao, Jim Wells & colleagues now published in PNAS!

LRP8-targeted KineTACs degrade LRP8, reduce GPX4 & other selenoproteins, and sensitize cancer cells to ferroptosis.

www.pnas.org/doi/10.1073/...
Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells | PNAS
Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limit...
www.pnas.org
September 30, 2026 at 11:32 PM
olzmannlab.bsky.social
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
vonkarstedtlab.bsky.social
What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social

rdcu.be/ejp9C
An atlas of ferroptosis-induced secretomes
Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes
rdcu.be
April 26, 2025 at 9:42 AM
brentstockwell.bsky.social
Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!
Ferroptosis—disease perils and therapeutic promise
Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment
www.science.org
November 22, 2024 at 2:48 AM
olzmannlab.bsky.social
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...
www.biorxiv.org
August 6, 2025 at 3:21 PM
vonkarstedtlab.bsky.social
Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez!

rdcu.be/d7L66
Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
rdcu.be
January 28, 2025 at 9:46 AM
labwaggoner.bsky.social
Placental trophoblasts exhibit iron dysregulation and ferroptosis signaling associated with SARS-CoV-2 restriction @cellreports.bsky.social @mysorekarlab.bsky.social
www.cell.com/cell-reports...
September 30, 2026 at 6:49 PM
natcellbio.nature.com
🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social
bit.ly/4l93AUW
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
bit.ly
August 2, 2025 at 7:04 PM
olzmannlab.bsky.social
1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology
Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...
www.nature.com
March 13, 2026 at 5:00 PM
angelifriedmann.bsky.social
🚨Preprint alert 🚨

We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.

www.biorxiv.org/content/10.1....

pls check @olzmannlab.bsky.social

www.biorxiv.org/content/10.1...

#ferroptosis #FSP1 #antioxidants
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
www.biorxiv.org
August 6, 2025 at 8:38 AM
olzmannlab.bsky.social
The first FASEB Ferroptosis conference! ✔️ Thank you to my co-organizer Scott Dixon, our sponsors, and the whole #Ferroptosis community for showing up and making this such a wonderful meeting! 🤩 ❤️
August 1, 2025 at 6:07 PM
barbmarte.bsky.social
new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
www.nature.com
November 6, 2025 at 7:39 AM
nature.com
Nature research paper: Activation of lysosomal iron triggers ferroptosis in cancer

https://go.nature.com/4jO9ZVX
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
go.nature.com
May 8, 2025 at 10:24 AM
angelifriedmann.bsky.social
Organelle conversations drive ferroptosis -

news and views on a recent study by @mariamls.bsky.social and colleagues

www.nature.com/articles/s41...
Organelle conversations drive ferroptosis - Nature Cell Biology
Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain....
www.nature.com
June 19, 2025 at 9:28 AM
brentstockwell.bsky.social
Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social
July 31, 2025 at 6:42 PM
frezzalab.bsky.social
Cytosolic cytochrome c represses ferroptosis: Cell Metabolism www.cell.com/cell-metabol...
Cytosolic cytochrome c represses ferroptosis
Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...
www.cell.com
April 17, 2025 at 5:54 PM
angelifriedmann.bsky.social
@olzmannlab.bsky.social and Scott Dixon kicking off the first Faseb research conference on Ferroptosis, Oxidative stress and Lipid Metabolism
#ferroptosis #celldeath
July 28, 2025 at 2:05 AM
brentstockwell.bsky.social
Great to be here and meet fellow ferroptosis researchers!
November 17, 2024 at 8:02 PM
nature.com
Nature research paper: Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

https://go.nature.com/4e1Wek9
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis - Nature
Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.
go.nature.com
June 17, 2025 at 8:52 AM
natcellbio.nature.com
☕This year, in our #CellDeath focus:
Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer.
👉https://rdcu.be/d493Q
www.nature.com/articles/s41...
Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology
Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...
www.nature.com
December 29, 2024 at 6:59 PM
ubellackerlab.bsky.social
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
August 18, 2025 at 3:42 PM
natcellbio.nature.com
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
bit.ly
November 16, 2025 at 8:38 AM
agostinislab.bsky.social
🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
doi.org
June 13, 2025 at 10:31 AM
frezzalab.bsky.social
Cytosolic cytochrome c represses ferroptosis: Cell Metabolism www.cell.com/cell-metabol...
Cytosolic cytochrome c represses ferroptosis
Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...
www.cell.com
June 5, 2025 at 2:41 PM