Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.

細胞死に関わる「FSP1」というタンパク質を操作すれば、がんの増殖を阻止できるかもしれない。希望が持てる2つの成果が同時に発表された。

がんの広がりを遅らせる新たな標的が見つかったかもしれない。がん細胞を自滅させるように操作できるタンパク質だ。2025年11月5日付で学術誌「ネイチャー」に発表された2つの論文によれば、研究者らは「フェロトーシス抑制タンパク質1（FSP1）」に注目している。「フェロトーシス」は、細胞を内側から破壊する細胞死の一つだ。FSP1は、この細胞死を防ぐ最も強力なメカニズムの一つを担っている。FSP1の

Nature Structural & Molecular Biology, Published online: 13 March 2026; doi:10.1038/s41594-026-01760-4The oxidoreductase FSP1 recycles radical-trapping antioxidants that suppress oxidative lipid damage and ferroptosis. A series of genetic screens reveal a key role for the vitamin B2 metabolite flavin adenine dinucleotide in stabilizing FSP1, preventing its proteasomal degradation and promoting ferroptosis suppression.

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.