A TurboID-based proximity labeling tool to track the plant secretomes
Lin et al.
nph.onlinelibrary.wiley.com/share/K9ABWG...
Lin et al.
nph.onlinelibrary.wiley.com/share/K9ABWG...
September 30, 2026 at 5:09 PM
A TurboID-based proximity labeling tool to track the plant secretomes
Lin et al.
nph.onlinelibrary.wiley.com/share/K9ABWG...
Lin et al.
nph.onlinelibrary.wiley.com/share/K9ABWG...
What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social
rdcu.be/ejp9C
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social
rdcu.be/ejp9C
An atlas of ferroptosis-induced secretomes
Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes
rdcu.be
April 26, 2025 at 9:42 AM
What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social
rdcu.be/ejp9C
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social
rdcu.be/ejp9C
New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch et al.
doi: doi.org/10.1101/2025...
Bosch et al.
doi: doi.org/10.1101/2025...
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...
doi.org
July 12, 2025 at 5:40 AM
New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Bosch et al.
doi: doi.org/10.1101/2025...
Bosch et al.
doi: doi.org/10.1101/2025...
Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...
www.biorxiv.org
January 14, 2026 at 12:34 AM
Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...
New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678
April 29, 2026 at 4:13 PM
New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678
This morning our co-Director and global leader in the field of cardiovascular calcification, Dr. Elena Aikawa, enlightened #USHUPO2025 attendees at the new Biofluids, Secretomes, and Extracellular Vesicles session created by @toleafgirl.bsky.social .
February 25, 2025 at 2:50 PM
This morning our co-Director and global leader in the field of cardiovascular calcification, Dr. Elena Aikawa, enlightened #USHUPO2025 attendees at the new Biofluids, Secretomes, and Extracellular Vesicles session created by @toleafgirl.bsky.social .
I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️.
Thread below🧵
1/8
www.biorxiv.org/content/10.1...
Thread below🧵
1/8
www.biorxiv.org/content/10.1...
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...
www.biorxiv.org
July 11, 2025 at 2:51 PM
I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️.
Thread below🧵
1/8
www.biorxiv.org/content/10.1...
Thread below🧵
1/8
www.biorxiv.org/content/10.1...
🛠️ February's most-read Tools and Resources paper looks at secretomes to provide insights into the unique mechanisms used by gall-forming microbes in plants: buff.ly/NUyYlWu
Learn more about publishing your tools or resources with us: buff.ly/jEBAOqN
Learn more about publishing your tools or resources with us: buff.ly/jEBAOqN
March 10, 2025 at 9:21 AM
🛠️ February's most-read Tools and Resources paper looks at secretomes to provide insights into the unique mechanisms used by gall-forming microbes in plants: buff.ly/NUyYlWu
Learn more about publishing your tools or resources with us: buff.ly/jEBAOqN
Learn more about publishing your tools or resources with us: buff.ly/jEBAOqN
Online Now: Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes #trends #endocrinology #metabolism
Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes
Secreted proteins regulate a range of physiological functions and pathologies; however, identifying these in vivo has been technically challenging. The article by Plucińska et al. introduces a genetically encoded proximity labelling mouse model, enabling the capture of cell-specific secretomes in plasma and tissue in response to physiological stressors.
dlvr.it
July 30, 2026 at 3:48 PM
Online Now: Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes #trends #endocrinology #metabolism
🌱 From Heliyon: Multitasking proteins in Xanthomonas secretomes may play hidden roles in virulence and plant-pathogen interactions. (Renata de Almeida Barbosa Assis, Abhaya M. Dandekar)
▶️ www.cell.com/heliyon/full...
#plantpathology #plantscience
▶️ www.cell.com/heliyon/full...
#plantpathology #plantscience
Exploring multitasking proteins in Xanthomonas secretomes: Insights into mechanisms of plant-pathogen interactions
Recent advances in large-scale functional genomic analysis have significantly increased
interest in multitask proteins. The role of these proteins in Xanthomonas phytopathogens,
a model for plant-path...
www.cell.com
May 29, 2025 at 11:23 PM
🌱 From Heliyon: Multitasking proteins in Xanthomonas secretomes may play hidden roles in virulence and plant-pathogen interactions. (Renata de Almeida Barbosa Assis, Abhaya M. Dandekar)
▶️ www.cell.com/heliyon/full...
#plantpathology #plantscience
▶️ www.cell.com/heliyon/full...
#plantpathology #plantscience
#Mechanobiology
#Hypertension
Bulk transcriptomes & secretomes of 👤aortic smooth muscle cell
Hydrostatic pressure
180/120 mmHg, 1 Hz
120/60 mmHg, 1 Hz
vs Cyclic stretch
10% strain, 1 Hz
vs static
Hypertensive pressure
⬆️HHIP, Netrin4, HGF
#JPhysiolSci 2026
www.sciencedirect.com/science/arti...
#Hypertension
Bulk transcriptomes & secretomes of 👤aortic smooth muscle cell
Hydrostatic pressure
180/120 mmHg, 1 Hz
120/60 mmHg, 1 Hz
vs Cyclic stretch
10% strain, 1 Hz
vs static
Hypertensive pressure
⬆️HHIP, Netrin4, HGF
#JPhysiolSci 2026
www.sciencedirect.com/science/arti...
August 6, 2026 at 1:05 PM
#Mechanobiology
#Hypertension
Bulk transcriptomes & secretomes of 👤aortic smooth muscle cell
Hydrostatic pressure
180/120 mmHg, 1 Hz
120/60 mmHg, 1 Hz
vs Cyclic stretch
10% strain, 1 Hz
vs static
Hypertensive pressure
⬆️HHIP, Netrin4, HGF
#JPhysiolSci 2026
www.sciencedirect.com/science/arti...
#Hypertension
Bulk transcriptomes & secretomes of 👤aortic smooth muscle cell
Hydrostatic pressure
180/120 mmHg, 1 Hz
120/60 mmHg, 1 Hz
vs Cyclic stretch
10% strain, 1 Hz
vs static
Hypertensive pressure
⬆️HHIP, Netrin4, HGF
#JPhysiolSci 2026
www.sciencedirect.com/science/arti...
Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
Plucińska et al. developed a genetically encoded TurboIDKDEL mouse model that enables cell-type-specific tagging of secreted proteomes in vivo. This approach was used to uncover dynamic, state-dependent changes in ER proteostasis and the circulating proteome in response to fasting, inflammation, and obesity, identifying candidate circulating biomarkers of human disease.
dlvr.it
July 7, 2026 at 7:50 PM
Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion
www.frontiersin.org/journals/phy...
www.frontiersin.org/journals/phy...
Frontiers | High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion
www.frontiersin.org
April 9, 2025 at 5:59 PM
High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion
www.frontiersin.org/journals/phy...
www.frontiersin.org/journals/phy...
MSCs exert their therapeutic effects via secreted factors but which MSC source is best & how do inflammatory cues alter the secretome and its effects?
Our latest paper profiled the secretome of different MSC types under resting and inflammatory conditions to answer these questions👇
rdcu.be/d8ypA
Our latest paper profiled the secretome of different MSC types under resting and inflammatory conditions to answer these questions👇
rdcu.be/d8ypA
Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing
npj Regenerative Medicine - Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing
rdcu.be
February 5, 2025 at 8:20 AM
MSCs exert their therapeutic effects via secreted factors but which MSC source is best & how do inflammatory cues alter the secretome and its effects?
Our latest paper profiled the secretome of different MSC types under resting and inflammatory conditions to answer these questions👇
rdcu.be/d8ypA
Our latest paper profiled the secretome of different MSC types under resting and inflammatory conditions to answer these questions👇
rdcu.be/d8ypA
🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...
April 24, 2025 at 12:32 PM
🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...
Exciting work! Plasmids can be found here: www.addgene.org/browse/artic...
July 11, 2025 at 5:42 PM
Exciting work! Plasmids can be found here: www.addgene.org/browse/artic...
Insights into the fungal secretomes and their roles in the formation and stabilization of the biogenic silver nanoparticles #RSCAdv #MassSpec pubs.rsc.org/en/content/a...
Insights into the fungal secretomes and their roles in the formation and stabilization of the biogenic silver nanoparticles
The biosynthesis of silver nanoparticles (AgNPs) using biological systems has emerged as a promising alternative to traditional chemical methods, providing eco-friendly solutions in nanotechnology. Th...
pubs.rsc.org
March 5, 2025 at 1:13 PM
Insights into the fungal secretomes and their roles in the formation and stabilization of the biogenic silver nanoparticles #RSCAdv #MassSpec pubs.rsc.org/en/content/a...
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
#Drosophila
#Drosophila
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
July 17, 2025 at 10:23 AM
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking
#Drosophila
#Drosophila
Excited that our tissue-secretome work is now PUBLISHED in @natcomms.nature.com!
Original preprint tutorial below 👇
Final paper expands bioinformatic analyses and details improved HDR donor plasmids for Gal4/GFP knock-ins (@addgene.bsky.social, @dgrc.bsky.social).
www.nature.com/articles/s41...
Original preprint tutorial below 👇
Final paper expands bioinformatic analyses and details improved HDR donor plasmids for Gal4/GFP knock-ins (@addgene.bsky.social, @dgrc.bsky.social).
www.nature.com/articles/s41...
June 19, 2026 at 5:11 PM
Excited that our tissue-secretome work is now PUBLISHED in @natcomms.nature.com!
Original preprint tutorial below 👇
Final paper expands bioinformatic analyses and details improved HDR donor plasmids for Gal4/GFP knock-ins (@addgene.bsky.social, @dgrc.bsky.social).
www.nature.com/articles/s41...
Original preprint tutorial below 👇
Final paper expands bioinformatic analyses and details improved HDR donor plasmids for Gal4/GFP knock-ins (@addgene.bsky.social, @dgrc.bsky.social).
www.nature.com/articles/s41...
Stem Cell Secretomes from Surgical Waste: A Novel Approach to Cancer Therapy : An In Vitro Study https://www.biorxiv.org/content/10.1101/2025.06.05.656255v1
June 6, 2025 at 11:30 AM
Stem Cell Secretomes from Surgical Waste: A Novel Approach to Cancer Therapy : An In Vitro Study https://www.biorxiv.org/content/10.1101/2025.06.05.656255v1
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking https://www.biorxiv.org/content/10.1101/2025.07.09.659702v1
July 11, 2025 at 2:33 PM
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking https://www.biorxiv.org/content/10.1101/2025.07.09.659702v1
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking https://www.biorxiv.org/content/10.1101/2025.07.09.659702v1
July 11, 2025 at 2:33 PM
Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking https://www.biorxiv.org/content/10.1101/2025.07.09.659702v1
Transcriptomic insights into the tripartite plant-pathogen-mycoparasite interaction reveal novel mechanisms involving fungal secretomes and plant amino acid metabolism https://www.biorxiv.org/content/10.1101/2025.11.24.690098v1
November 26, 2025 at 12:16 AM
Transcriptomic insights into the tripartite plant-pathogen-mycoparasite interaction reveal novel mechanisms involving fungal secretomes and plant amino acid metabolism https://www.biorxiv.org/content/10.1101/2025.11.24.690098v1
@thermofishersci.bsky.social's resource, RRID:AB_2534673, was just reported to be used in the paper. Thanks for making your methods matter! #BetterScience #OpenScience #methodsmatter
Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
Read the full paper: Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
doi.org
June 14, 2026 at 7:00 AM
@thermofishersci.bsky.social's resource, RRID:AB_2534673, was just reported to be used in the paper. Thanks for making your methods matter! #BetterScience #OpenScience #methodsmatter
DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...
DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic, immunosuppressive stroma dominated by cancer-associated fibroblasts (CAFs). Paracrine signals from cancer cells and CAFs sha...
www.biorxiv.org
December 1, 2025 at 7:19 PM
DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...