Can lipids alone map the brain? 🧠
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
November 3, 2026 at 5:52 PM
Can lipids alone map the brain? 🧠
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 4, 2026 at 2:43 PM
Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Me getting my lipid panel and PSA
I AM NOT GOING TO LOOK AT YOUR FUCKING NEEDLE YOU CANNOT MAKE ME
November 4, 2026 at 1:12 AM
Me getting my lipid panel and PSA
Prokaryotes bridging the lipid divide academic.oup.com/femsre/advan... #jcampubs
November 2, 2026 at 2:33 PM
Prokaryotes bridging the lipid divide academic.oup.com/femsre/advan... #jcampubs
Phosphatidylcholine acyl turnover facilitates thylakoid lipid remodeling and promotes plant survival under heat stress
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
November 3, 2026 at 7:59 PM
Phosphatidylcholine acyl turnover facilitates thylakoid lipid remodeling and promotes plant survival under heat stress
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
mRNA’s therapeutic potential was recognized for decades, but lipid nanoparticle research made it a reality. Nature Materials reports how researchers now aim to boost efficacy and reduce side effects to extend these delivery agents beyond vaccines. go.nature.com/4iOlG0y 🧪
November 2, 2026 at 5:08 PM
mRNA’s therapeutic potential was recognized for decades, but lipid nanoparticle research made it a reality. Nature Materials reports how researchers now aim to boost efficacy and reduce side effects to extend these delivery agents beyond vaccines. go.nature.com/4iOlG0y 🧪
would generate large amounts of protein in the target tissues. They screened libraries of delivery particles containing both polymer and lipid components, which have been used separately to achieve efficient mRNA delivery. From these screens, they identified one polymer-lipid particle that was
October 30, 2026 at 4:10 PM
would generate large amounts of protein in the target tissues. They screened libraries of delivery particles containing both polymer and lipid components, which have been used separately to achieve efficient mRNA delivery. From these screens, they identified one polymer-lipid particle that was
Adding lipid tails to drug substances is a classic way to change their uptake and distribution. But the effects in different sorts of cells can vary widely:
Lipidation and Its Discontents
www.science.org
November 3, 2026 at 8:08 PM
Adding lipid tails to drug substances is a classic way to change their uptake and distribution. But the effects in different sorts of cells can vary widely:
Finally
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
Cargo levels control endosomal PI(3)P homeostasis through direct feedback between SNX17 and MTM1
The sorting of internalised cell surface proteins through the endosomal network is crucial for cellular function. Phosphatidylinositol-3-phosphate (PI(3)P) is a critical lipid identity cue for organis...
www.biorxiv.org
November 3, 2026 at 4:19 PM
Finally
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
Prokaryotes bridging the lipid divide
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
Prokaryotes bridging the lipid divide
Abstract. The fundamental biochemical and stereochemical difference in how cell membrane lipids are built between Archaea on one side, and Bacteria and Euk
doi.org
November 3, 2026 at 8:34 AM
Prokaryotes bridging the lipid divide
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
New Article! Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
Nature Protocols, Published online: 03 November 2026; doi:10.1038/s41596-026-01451-wThis Protocol describes a robust workflow for pharmacological induction, purification and characterization of mature lipid droplets from primary cortical neurons with minimal detected cytosolic membrane carryover.
dlvr.it
November 3, 2026 at 11:00 PM
New Article! Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
Eyes like lipid pools...
Goodnight Bob 🫶
Goodnight Bob 🫶
November 3, 2026 at 11:57 PM
Eyes like lipid pools...
Goodnight Bob 🫶
Goodnight Bob 🫶
New in @jacs.acspublications.org: Brian Chen & @adi-bhatta.bsky.social used photoaffinity labeling to map the localization & interactome of the amphiphilic lipid lysophosphatidic acid & found nanoscale-level heterogeneity within ER membranes! pubs.acs.org/jacsat/artic... @weillinstitute.bsky.social
November 4, 2026 at 7:42 PM
New in @jacs.acspublications.org: Brian Chen & @adi-bhatta.bsky.social used photoaffinity labeling to map the localization & interactome of the amphiphilic lipid lysophosphatidic acid & found nanoscale-level heterogeneity within ER membranes! pubs.acs.org/jacsat/artic... @weillinstitute.bsky.social
New Online! Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
Nature Reviews Molecular Cell Biology, Published online: 02 November 2026; doi:10.1038/s41580-026-01049-wGolgi-derived vesicles that contain phosphatidylinositol 3,4-bisphosphate facilitate mitochondrial fusion at sites marked with mitofusins and endoplasmic reticulum.
dlvr.it
November 2, 2026 at 3:48 PM
New Online! Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
'Here we show that the innate and adaptive immune responses elicited by LNPs are linked to their ionizable lipid chemistry. Specifically, we show that the amine headgroups in ionizable lipids drive LNP immunogenicity by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.'
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d - Nature Biomedical Engineering
Amine headgroups in ionizable lipids drive the immunogenicity of lipid nanoparticles by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.
www.nature.com
November 2, 2026 at 9:32 AM
'Here we show that the innate and adaptive immune responses elicited by LNPs are linked to their ionizable lipid chemistry. Specifically, we show that the amine headgroups in ionizable lipids drive LNP immunogenicity by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.'
7) Regarding the metabolic shift the authors write:
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
November 4, 2026 at 9:33 AM
7) Regarding the metabolic shift the authors write:
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
🐁 New study indicates that maternal nano #plastic exposure during gestation & lactation induces vascular injury & lipid deposition in mouse offspring. Polystyrene may be a critical environmental risk factor for offspring cardiovascular adverse outcomes later in life.
academic.oup.com/toxsci/artic...
academic.oup.com/toxsci/artic...
Maternal gestational and lactational exposure to polystyrene nanoplastics triggers vascular injury and lipid deposition in mouse offspring
Abstract. As pervasive environmental contaminants, nanoplastics (NPs) have garnered increasing concern due to their potential health hazards. However, the
academic.oup.com
November 2, 2026 at 3:26 PM
🐁 New study indicates that maternal nano #plastic exposure during gestation & lactation induces vascular injury & lipid deposition in mouse offspring. Polystyrene may be a critical environmental risk factor for offspring cardiovascular adverse outcomes later in life.
academic.oup.com/toxsci/artic...
academic.oup.com/toxsci/artic...
'mRNA potential has been on the radar for decades..'
Which anti-covid vax nitwits called 'new' and 'experimental.'
It's not like these high skool flunkies know scientists discovered mRNA about six decades ago or that medical research has been underway for about five.
www.nature.com/articles/s41...
Which anti-covid vax nitwits called 'new' and 'experimental.'
It's not like these high skool flunkies know scientists discovered mRNA about six decades ago or that medical research has been underway for about five.
www.nature.com/articles/s41...
Lipid nanoparticles call the shots as mRNA medicine takes off
Nature Materials - The therapeutic potential of mRNA had been on the radar for decades but it took an alliance with lipid nanoparticle research to make it a reality. Researchers are now looking for...
www.nature.com
November 2, 2026 at 6:32 PM
'mRNA potential has been on the radar for decades..'
Which anti-covid vax nitwits called 'new' and 'experimental.'
It's not like these high skool flunkies know scientists discovered mRNA about six decades ago or that medical research has been underway for about five.
www.nature.com/articles/s41...
Which anti-covid vax nitwits called 'new' and 'experimental.'
It's not like these high skool flunkies know scientists discovered mRNA about six decades ago or that medical research has been underway for about five.
www.nature.com/articles/s41...
Reconstitution of lipid nanoparticle-mediated siRNA transfer across endosomal membrane mimics https://www.biorxiv.org/content/10.64898/2026.11.02.763664v1
November 3, 2026 at 12:30 PM
Reconstitution of lipid nanoparticle-mediated siRNA transfer across endosomal membrane mimics https://www.biorxiv.org/content/10.64898/2026.11.02.763664v1
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Frontiers | Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris cl...
www.frontiersin.org
November 2, 2026 at 1:32 PM
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Bacteriophages encode #lysis proteins that inhibit essential bacterial processes. This study solves the #cryoEM #structure of an E. coli lipid II flippase complex with a phage lysis protein, showing that the flippase is locked in an outward facing conformation.
🧪 #AcademicSky
plos.io/4iJInTD
🧪 #AcademicSky
plos.io/4iJInTD
October 31, 2026 at 5:02 PM
Bacteriophages encode #lysis proteins that inhibit essential bacterial processes. This study solves the #cryoEM #structure of an E. coli lipid II flippase complex with a phage lysis protein, showing that the flippase is locked in an outward facing conformation.
🧪 #AcademicSky
plos.io/4iJInTD
🧪 #AcademicSky
plos.io/4iJInTD
Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance https://www.biorxiv.org/content/10.64898/2026.11.03.764129v1
November 4, 2026 at 7:18 PM
Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance https://www.biorxiv.org/content/10.64898/2026.11.03.764129v1
Lipid Hydrogen Stable Isotope Probing Reveals Archaeal Lipid Turnover in Hot Spring Sediments
Harris, Kopf, Amenabar et al.
Journal of Geophysical Research: Biogeosciences
https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2026jg010076
#stableisotopes
Harris, Kopf, Amenabar et al.
Journal of Geophysical Research: Biogeosciences
https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2026jg010076
#stableisotopes
Lipid Hydrogen Stable Isotope Probing Reveals Archaeal Lipid Turnover in Hot Spring Sediments
Lipid hydrogen stable isotope probing is applied to high temperature hot spring sediments for the first time Sedimentary archaeal lipids in hot springs exhibit apparent turnover on decadal timesc...
agupubs.onlinelibrary.wiley.com
October 30, 2026 at 7:49 PM
Lipid Hydrogen Stable Isotope Probing Reveals Archaeal Lipid Turnover in Hot Spring Sediments
Harris, Kopf, Amenabar et al.
Journal of Geophysical Research: Biogeosciences
https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2026jg010076
#stableisotopes
Harris, Kopf, Amenabar et al.
Journal of Geophysical Research: Biogeosciences
https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2026jg010076
#stableisotopes