Overcoming #ChemotherapyResistance remains a major challenge.
This study identifies #m6A-modified circLPAR3 as a driver of docetaxel resistance in #ProstateCancer, highlighting a potential target for restoring treatment response.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study identifies #m6A-modified circLPAR3 as a driver of docetaxel resistance in #ProstateCancer, highlighting a potential target for restoring treatment response.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 3, 2026 at 2:01 PM
Overcoming #ChemotherapyResistance remains a major challenge.
This study identifies #m6A-modified circLPAR3 as a driver of docetaxel resistance in #ProstateCancer, highlighting a potential target for restoring treatment response.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study identifies #m6A-modified circLPAR3 as a driver of docetaxel resistance in #ProstateCancer, highlighting a potential target for restoring treatment response.
#GenesAndDiseases: doi.org/10.1016/j.ge...
m6A-modified hsa_circ_0010996 regulates ferroptosis in anti-tuberculosis drug-induced liver injury cells by binding to EIF4A3
Toxicology and applied pharmacology · Wang et al.
doi.org/10.1016/j.taap.2026.118100
#RNAsky #RNAmods
Toxicology and applied pharmacology · Wang et al.
doi.org/10.1016/j.taap.2026.118100
#RNAsky #RNAmods
m6A-modified hsa_circ_0010996 regulates ferroptosis in anti-tuberculosis drug-induced liver injury cells by binding to EIF4A3
Toxicology and applied pharmacology · Wang Q, Long M, Song T, Yao J, Liu Y, Meng C, Feng F.
doi.org
November 4, 2026 at 8:24 PM
m6A-modified hsa_circ_0010996 regulates ferroptosis in anti-tuberculosis drug-induced liver injury cells by binding to EIF4A3
Toxicology and applied pharmacology · Wang et al.
doi.org/10.1016/j.taap.2026.118100
#RNAsky #RNAmods
Toxicology and applied pharmacology · Wang et al.
doi.org/10.1016/j.taap.2026.118100
#RNAsky #RNAmods
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2
Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2
Molecular and cellular biochemistry · Yan WZ, Wang JY, Chen YY, Zhang M, Liu GY, He LY.
doi.org
November 2, 2026 at 10:16 PM
M6A-modified Gata1 promotes endoplasmic reticulum stress during acute kidney injury via suppressing Sesn2 : Gata1 promotes acute kidney injury by downregulating Sesn2
Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
Molecular and cellular biochemistry · Yan et al.
doi.org/10.1007/s11010-026-05785-7
#RNAsky #RNAmods
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu Y, Zhang Z, Yu Y, Chai Y, Hao J, Qiao Q.
doi.org
October 29, 2026 at 6:55 PM
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
Uxie 148/103 in Pokémon's 30th CELEBRATION (M6a) set reprints a card whose old Set Up ability once made it a Modified-format go-to, per Samurai Sword Tokyo. Good pick for the Classic Collection block. Rip it or send it sealed? Link in bio for slirpz.com.
October 24, 2026 at 9:30 AM
Uxie 148/103 in Pokémon's 30th CELEBRATION (M6a) set reprints a card whose old Set Up ability once made it a Modified-format go-to, per Samurai Sword Tokyo. Good pick for the Classic Collection block. Rip it or send it sealed? Link in bio for slirpz.com.
CUX1 Modified by m6A Methylation Drives Benign Prostatic Hyperplasia via the PI3K/AKT/mTOR Signaling Pathway
The international journal of biochemistry & cell biology · Ye et al.
doi.org/10.1016/j.biocel.2026.107051
#RNAsky #RNAmods
The international journal of biochemistry & cell biology · Ye et al.
doi.org/10.1016/j.biocel.2026.107051
#RNAsky #RNAmods
CUX1 Modified by m6A Methylation Drives Benign Prostatic Hyperplasia via the PI3K/AKT/mTOR Signaling Pathway
The international journal of biochemistry & cell biology · Ye F, Zhu J, Lei Z.
doi.org
October 20, 2026 at 5:54 PM
CUX1 Modified by m6A Methylation Drives Benign Prostatic Hyperplasia via the PI3K/AKT/mTOR Signaling Pathway
The international journal of biochemistry & cell biology · Ye et al.
doi.org/10.1016/j.biocel.2026.107051
#RNAsky #RNAmods
The international journal of biochemistry & cell biology · Ye et al.
doi.org/10.1016/j.biocel.2026.107051
#RNAsky #RNAmods
RNA修飾の空間分布
近接標識と質量分析を組み合わせた手法APEX-RNA-MSにより、特定の細胞内区画に局在するRNAの修飾状態を検証。DNA損傷箇所にm6Aやm5Cが蓄積したり、ストレス顆粒にtRNAが集積したりするらしい
www.cell.com/cell-chemica...
近接標識と質量分析を組み合わせた手法APEX-RNA-MSにより、特定の細胞内区画に局在するRNAの修飾状態を検証。DNA損傷箇所にm6Aやm5Cが蓄積したり、ストレス顆粒にtRNAが集積したりするらしい
www.cell.com/cell-chemica...
Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS
Seo et al. develop APEX-RNA-MS, a strategy integrating proximity labeling and nucleoside mass spectrometry, to characterize the spatial distribution of modified RNAs within human cells. They profile…
www.cell.com
September 22, 2026 at 10:01 AM
RNA修飾の空間分布
近接標識と質量分析を組み合わせた手法APEX-RNA-MSにより、特定の細胞内区画に局在するRNAの修飾状態を検証。DNA損傷箇所にm6Aやm5Cが蓄積したり、ストレス顆粒にtRNAが集積したりするらしい
www.cell.com/cell-chemica...
近接標識と質量分析を組み合わせた手法APEX-RNA-MSにより、特定の細胞内区画に局在するRNAの修飾状態を検証。DNA損傷箇所にm6Aやm5Cが蓄積したり、ストレス顆粒にtRNAが集積したりするらしい
www.cell.com/cell-chemica...
New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified.
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
September 21, 2026 at 2:46 PM
New public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified.
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway
Cell reports. Medicine · Zhou et al.
doi.org/10.1016/j.xcrm.2026.103045
#RNAsky #RNAmods
Cell reports. Medicine · Zhou et al.
doi.org/10.1016/j.xcrm.2026.103045
#RNAsky #RNAmods
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway
We identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts their interaction with N6-methyladenosine (m6A)-modified RNAs.
doi.org
September 17, 2026 at 9:06 PM
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway
Cell reports. Medicine · Zhou et al.
doi.org/10.1016/j.xcrm.2026.103045
#RNAsky #RNAmods
Cell reports. Medicine · Zhou et al.
doi.org/10.1016/j.xcrm.2026.103045
#RNAsky #RNAmods
circNfix attenuates acute kidney injury by driving m6A-dependent degradation of YTHDF2 to stabilize DAPK2 mRNA
Clinical science (London, England : 1979) · Ma et al.
doi.org/10.1042/cs20261973
#RNAsky #RNAmods
Clinical science (London, England : 1979) · Ma et al.
doi.org/10.1042/cs20261973
#RNAsky #RNAmods
circNfix attenuates acute kidney injury by driving m6A-dependent degradation of YTHDF2 to stabilize DAPK2 mRNA
Here, we identify a novel mechanism by which the m6A-modified circRNA circNfix contributes to the regulation of septic AKI (SAKI).
doi.org
September 16, 2026 at 1:19 PM
circNfix attenuates acute kidney injury by driving m6A-dependent degradation of YTHDF2 to stabilize DAPK2 mRNA
Clinical science (London, England : 1979) · Ma et al.
doi.org/10.1042/cs20261973
#RNAsky #RNAmods
Clinical science (London, England : 1979) · Ma et al.
doi.org/10.1042/cs20261973
#RNAsky #RNAmods
IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA
Medical oncology (Northwood, London, England) · Yi et al.
doi.org/10.1007/s12032-026-03383-7
#RNAsky #RNAmods
Medical oncology (Northwood, London, England) · Yi et al.
doi.org/10.1007/s12032-026-03383-7
#RNAsky #RNAmods
IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA
Medical oncology (Northwood, London, England) · Yi H, Han Y, Wang X, Li Q, Xiong L, Li S.
doi.org
September 11, 2026 at 1:19 PM
IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA
Medical oncology (Northwood, London, England) · Yi et al.
doi.org/10.1007/s12032-026-03383-7
#RNAsky #RNAmods
Medical oncology (Northwood, London, England) · Yi et al.
doi.org/10.1007/s12032-026-03383-7
#RNAsky #RNAmods
Restoration of m6A-Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Tang et al.
doi.org/10.1002/advs.77417
#RNAsky #RNAmods
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Tang et al.
doi.org/10.1002/advs.77417
#RNAsky #RNAmods
Restoration of m6A-Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention
Here, we identify circPSMB1 as a significantly downregulated circRNA in chordoma tissues through high-throughput circRNA sequencing.
doi.org
September 2, 2026 at 1:07 PM
Restoration of m6A-Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Tang et al.
doi.org/10.1002/advs.77417
#RNAsky #RNAmods
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Tang et al.
doi.org/10.1002/advs.77417
#RNAsky #RNAmods
New study suggests YTHDF2 might have dual reader capacity for m5C and m6A. Would be an interesting read
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell
cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby
serving as a dual reader for...
www.cell.com
January 23, 2025 at 10:29 PM
New study suggests YTHDF2 might have dual reader capacity for m5C and m6A. Would be an interesting read
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease #NeuroDegeneration
Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.05.02.651974v1
https://www.biorxiv.org/content/10.1101/2025.05.02.651974v1
May 7, 2025 at 10:26 AM
Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease #NeuroDegeneration
New Article: "N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis" rdcu.be/dAvYN
In response to ABA, m6A reader ECT8 sequesters m6A-modified ABA receptor PYL7 mRNA in stress granules. #PlantScience
In response to ABA, m6A reader ECT8 sequesters m6A-modified ABA receptor PYL7 mRNA in stress granules. #PlantScience
March 6, 2024 at 4:39 PM
New Article: "N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis" rdcu.be/dAvYN
In response to ABA, m6A reader ECT8 sequesters m6A-modified ABA receptor PYL7 mRNA in stress granules. #PlantScience
In response to ABA, m6A reader ECT8 sequesters m6A-modified ABA receptor PYL7 mRNA in stress granules. #PlantScience
We find that m6A modification is highly variable across transcripts, with enrichment at the 5'UTR and transcription start sites. Highly m6A-modified transcripts are associated with immune system processes, while those with lower m6A are associated with homeostatic translation.
4/5
4/5
October 15, 2025 at 3:27 PM
We find that m6A modification is highly variable across transcripts, with enrichment at the 5'UTR and transcription start sites. Highly m6A-modified transcripts are associated with immune system processes, while those with lower m6A are associated with homeostatic translation.
4/5
4/5
It's been known for a good while (pubmed.ncbi.nlm.nih.gov/32313079/) which is why when looking at CoVs we supplemented meRIPSeq with an orthologous approach (comparative nanopore sequencing using a small molecule METTL3 inhibitor). Still found a number of coinciding results...
Limits in the detection of m6A changes using MeRIP/m6A-seq - PubMed
Many cellular mRNAs contain the modified base m<sup>6</sup>A, and recent studies have suggested that various stimuli can lead to changes in m<sup>6</sup>A. The most common method to map m<sup>6</sup>A...
pubmed.ncbi.nlm.nih.gov
October 14, 2023 at 5:12 PM
It's been known for a good while (pubmed.ncbi.nlm.nih.gov/32313079/) which is why when looking at CoVs we supplemented meRIPSeq with an orthologous approach (comparative nanopore sequencing using a small molecule METTL3 inhibitor). Still found a number of coinciding results...
Now online! Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism
Ogawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine clearance pathway leads to toxic metabolite buildup, AMPK inhibition, and metabolic dysfunction in animal models and human disease.
dlvr.it
August 20, 2025 at 2:59 PM
Now online! Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism
#PublicationSpotlight 🔦
Why Are Some Cancer Cells Resistant to CAR-T Therapy?
Publication: YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies:
www.cell.com/cell/abstrac...
#WhenYouNeedItAll Proteintech is here to support your journey to publication success.
Why Are Some Cancer Cells Resistant to CAR-T Therapy?
Publication: YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies:
www.cell.com/cell/abstrac...
#WhenYouNeedItAll Proteintech is here to support your journey to publication success.
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2 modulates oncogenic transformation and immune evasion across multiple B cell cancers by stabilizing m5C-modified mRNAs and destabilizing m6A-modified mRNAs, thereby serving as a dual reader for both m5C and m6A modifications. Small molecules that target YTHDF2 reduce ATP synthesis and are therapeutic candidates for B cell malignancies, especially when combined with CAR-T therapy or bispecific engagers.
ow.ly
January 10, 2025 at 11:05 AM
#PublicationSpotlight 🔦
Why Are Some Cancer Cells Resistant to CAR-T Therapy?
Publication: YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies:
www.cell.com/cell/abstrac...
#WhenYouNeedItAll Proteintech is here to support your journey to publication success.
Why Are Some Cancer Cells Resistant to CAR-T Therapy?
Publication: YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies:
www.cell.com/cell/abstrac...
#WhenYouNeedItAll Proteintech is here to support your journey to publication success.
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing.
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
November 28, 2024 at 12:12 PM
We have been busing working on models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanoporetech.com direct RNA sequencing.
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
This is still very preliminary but here are a few examples of what it looks like on Human #rRNA prepared with standard lib prep 🤩
Neat paper in JACS. They use a modified version of RhoBAST to do super-res imaging of demethylation of m6A by FTO pubs.acs.org/doi/10.1021/...
Developments of the mDZ-RhoBAST Probe for Super-Resolution Imaging of FTO Demethylation in Live Cells
Single-molecule localization microscopy (SMLM) provides precise, high-resolution visualization of target biomolecules in cellular imaging. Fluorescent light-up aptamers (FLAPs) offer a versatile appro...
pubs.acs.org
May 6, 2025 at 8:46 PM
Neat paper in JACS. They use a modified version of RhoBAST to do super-res imaging of demethylation of m6A by FTO pubs.acs.org/doi/10.1021/...
New #OpenAccess study in #BMCBiology investigated the role of N6-methyladenosine-modified circZNF548 in the proliferation and migration of non-small cell lung cancer (NSCLC) within the tumor microenvironment (TME) 🫁
bmcbiol.biomedcentral.com/articles/10.... 🧪 #ImmunoSky #RNASky #CancerSky
bmcbiol.biomedcentral.com/articles/10.... 🧪 #ImmunoSky #RNASky #CancerSky
m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3+CD8+ T cells and suppress NSCLC growth by JMY - BMC Biology
Background Communication between cancer cells and tumor microenvironment (TME) plays a complicated role in cancer malignancy. Circular RNAs (circRNAs), known for their stability and conservation, cont...
bmcbiol.biomedcentral.com
August 25, 2025 at 6:12 PM
New #OpenAccess study in #BMCBiology investigated the role of N6-methyladenosine-modified circZNF548 in the proliferation and migration of non-small cell lung cancer (NSCLC) within the tumor microenvironment (TME) 🫁
bmcbiol.biomedcentral.com/articles/10.... 🧪 #ImmunoSky #RNASky #CancerSky
bmcbiol.biomedcentral.com/articles/10.... 🧪 #ImmunoSky #RNASky #CancerSky
They found that multiple RNA modifications (m5C, m6A, m5U, s2U, or pseudouridine ablated immune stimulation. This ultimately led to the ability to use modified mRNAs as vaccines. Unexpected payoff for an important basic science experiment 3/n
October 2, 2023 at 11:18 PM
They found that multiple RNA modifications (m5C, m6A, m5U, s2U, or pseudouridine ablated immune stimulation. This ultimately led to the ability to use modified mRNAs as vaccines. Unexpected payoff for an important basic science experiment 3/n
RRID:AB_2142033 from @proteintech.bsky.social was used by authors in their Cancer Research paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #reproducibility
Alcohol-Induced Metabolic Stress Sensed by m6A-Modified ChREBP Drives Immune Evasion in Esophageal Carcinogenesis
Read the full paper: Alcohol-Induced Metabolic Stress Sensed by m6A-Modified ChREBP Drives Immune Evasion in Esophageal Carcinogenesis
doi.org
July 22, 2026 at 7:01 AM
RRID:AB_2142033 from @proteintech.bsky.social was used by authors in their Cancer Research paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #reproducibility