#DNArepair
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gmj-georgia.bsky.social
Breaking: Scientists discover EXO1, a DNA-protective gene, becomes dangerous when overproduced in cancer cells—and this vulnerability could be explo…

#Cancergenomics #DNArepair #EXO1gene #Precisiononcology #Syntheticlethality

#Cancergenomics #DNArepair #EXO1gene #Precisiononcology #Syntheticlet…
DNA Repair Gene Becomes Cancer Weakness
Breaking: Scientists discover EXO1, a DNA-protective gene, becomes dangerous when overproduced in cancer cells—and this vulnerability could be explo… #Cancergenomics #DNArepair #EXO1gene #Precisiononcology #Syntheticlethality
news.gmj.ge
November 1, 2026 at 11:26 AM
genesdev.bsky.social
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity
By Ashour et al. and Nima Mosammaparast
➡️ https://ow.ly/FaLx51012Xo

#DNArepair #cancer #chemotherapy
October 29, 2026 at 3:00 PM
epigenometech.bsky.social
Epigenetics Update - PARP1 directly disassembles nucleosomes to regulate DNA repair www.cell.com/molecular-ce...

Ashish Verma/Changlei Zhu and Hai T. Dao (St. Jude Children's Research Hospital) in Molecular Cell

#Epigenetics #PPAR1 #Nucleosomes #DNARepair
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epigenometech.com
October 30, 2026 at 8:02 AM
genesndiseases.bsky.social
Why do some #cancers resist treatment despite advances in therapy?
This review reveals how #lncRNAs such as HOTAIR and MALAT1 drive resistance through key signaling and #DNArepair pathways, highlighting targets to improve therapy.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 24, 2026 at 2:03 PM
genesndiseases.bsky.social
#EpigeneticDysregulation can drive #cancer.
This review highlights CXorf67’s roles in PRC2 regulation, histone modification and #DNArepair, linking it to multiple malignancies and highlighting its potential as a therapeutic target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 16, 2026 at 12:15 PM
nicolocovelli.bsky.social
Although these approaches need further research and validation, they offer new strategies to treat cancers in a safe and efficient way.

👉️ Read more: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm
October 12, 2026 at 10:01 AM
nicolocovelli.bsky.social
Whales, on the other hand, have an enhanced capacity to repair DNA lesions before they become permanent mutations in the genome. This is made possible by the overexpression of CIRBP.

👉️ Read more: themolecularcode.substack.com/p/from-whale...
#CancerBiology #MolecularBiology #DNARepair #SciComm
October 9, 2026 at 10:01 AM
narjournal.bsky.social
⭐ How does the #BRCA network protect genome stability, and how can its vulnerabilities guide #cancertreatment? Explore 17 #NARCancer articles curated for the NAR Journals’ RRS session. #RadiationResearchSocietyMeeting #DNARepair @aibsbiology.bsky.social @nar-cancer-editor.bsky.social 1/18
October 7, 2026 at 1:44 AM
narjournal.bsky.social
14. Targeting DNA repair mechanisms in cancer therapy: the role of #smallmolecule #DNArepair inhibitors - Jeong et al. doi.org/10.1093/narc... “Editor’s Choice” review article detailing the current pipeline of repair inhibitors, synthetic lethality, biomarkers, and their combinations. 15/18
Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors
Abstract. Genomic instability and the accumulation of DNA damage are hallmarks of cancer, often resulting from defects in DNA repair pathways. While normal
doi.org
October 7, 2026 at 1:44 AM
sigtrans-sttt.bsky.social
Can hyperactive #DNArepair be targeted in #Neuroendocrine #CervicalCarcinoma?

#Multiomics reveals HRR activation and a CAF–IL6–E2F1–BLM axis that limits #PARP inhibitor sensitivity, supporting dual PARP–BLM inhibition.

#STTT #OpenAccess: doi.org/10.1038/s413...
Multi-omics profiling reveals homologous recombination repair hyperactivation as a therapeutic vulnerability in neuroendocrine cervical carcinoma
October 6, 2026 at 5:47 AM
nicolocovelli.bsky.social
One explanation is that different species have evolved distinct anti-cancer strategies. Bowhead whales evolved a mechanism that allows them to faithfully repair DNA lesions.

👉️ Read more: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm
October 5, 2026 at 10:01 AM
nicolocovelli.bsky.social
How can bowhead whales live for so long with such a low incidence of cancer?
The answer lies in the overexpression of CIRBP that enhances the cell's ability to repair DNA lesions.

👉️ Full story here: themolecularcode.substack.com/p/from-whale...

#CancerBiology #MolecularBiology #DNARepair #SciComm
From whales to humans: what the CIRBP protein can teach us about cancer resistance
Increased expression of this protein explains how bowhead whales possess an enhanced ability to repair their DNA.
themolecularcode.substack.com
October 2, 2026 at 10:00 AM
genesdev.bsky.social
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities
By Jayachandran et al. and Petr Cejka
➡️ https://ow.ly/IFke50ZRacV

Petr Cejka Institute for Research in Biomedicine Università della Svizzera italiana
#DNA #DNArepair
September 29, 2026 at 3:00 PM
cddpress.bsky.social
“DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation”

This work highlights a new mechanism controlling #DNARepair and tumor cell sensitivity to #chemotherapy ⤵️
nature.com/articles/s41...
DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation - Cell Death & Differentiation
Cell Death & Differentiation - DDX3X regulates DNA repair pathway choice at double-strand breaks via RNA-DNA hybrid formation
nature.com
September 28, 2026 at 11:53 AM
mhr-reprodsci.bsky.social
Findings:

🔬 Oocytes survived DNA breaks & fertilized.

🔬 Embryos faced DNA damage & developmental delays.

🔬 Offspring showed a spike in de novo (post-zygotic) mutations!

Read it here: academic.oup.com/molehr/advan...
#Genetics #DNARepair #Embryology #ESHRE
Maternal DNA repair safeguards genome stability during the oocyte-to-embryo transition
Abstract. De novo mutations are a major source of genetic variation and disease risk, yet the developmental timing and mechanisms underlying their origin r
academic.oup.com
September 21, 2026 at 9:22 AM
narjournal.bsky.social
✨NAR Molecular Medicine✨
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social
September 16, 2026 at 4:43 AM
fdadf.bsky.social
🚨 Can DNA that does nothing become a cell’s Achilles’ heel?

🧬 Cas9 selectively killed human cells carrying a non-functional target sequence, sparing cells without it.

www.sciencedirect.com/science/arti...

#CRISPR #DNARepair
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome
The CRISPR/Cas9 technology is a powerful and versatile tool to disrupt genes’ functions by introducing sequence-specific DNA double-strand breaks (DSB…
www.sciencedirect.com
September 14, 2026 at 11:39 AM
sbgrid.bsky.social
The not so easy job of protecting our DNA: a publication in @natsmb.nature.com from the lab of Nikola Pavletich at @mskcancercenter.bsky.social in which researchers describe the structure of ATR-ATRIP complex bound to its two activators.
Read more here: buff.ly/S5IWOVw

#SBGrid #DNARepair
The not so easy job of protecting our DNA
SBGrid member Nikola Pavletich reports on the structure of ATR-ATRIP complex bound to two activators, revealing key DNA-damage checkpoints.
medium.com
September 10, 2026 at 4:05 PM
nicolocovelli.bsky.social
This reveals how RNA-binding proteins activate DNA-damage sensors, opening precise and reversible strategies to bypass tumor resistance.

📄 Source: www.cell.com/molecular-ce...

#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
September 10, 2026 at 10:00 AM
genesdev.bsky.social
RESEARCH PAPER: MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice
By Lukaszewicz et al., Scott Keeney, and Maria Jasin
➡️ https://genesdev.cshlp.org/content/40/17-18/1466.full

Memorial Sloan Kettering Cancer Center University of Michigan
#DNArepair #mutagenesis #genome
September 9, 2026 at 6:00 PM
alicefrolov.bsky.social
Sharing a heatmap from an ongoing methodological exercise: "Age-associated erosion of DNA repair pathway capacity across human tissues"

#DNArepair #DNAdamageResponse #GenomeInstability #BasexcisionRepair #HomologousRecombination #GenomeMaintenance #Mutagenesis
Sharing a heatmap from an ongoing methodological exercise: "Age-associated erosion of DNA repair pathway capacity across human tissues," with the subtitle "Simulated relative repair activity for six core DNA damage response pathways (young vs aged donors)." The visualization arranges six canonical DNA damage response (DDR) pathways along the vertical axis: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), non-homologous end joining (NHEJ), and interstrand crosslink repair (the Fanconi anemia pathway). The horizontal axis stratifies representative tissue compartments (hematopoietic, hepatic, dermal, skeletal muscle, cortical neuronal, and intestinal epithelium) in paired young and aged donor columns. Cell values encode relative repair activity normalized within pathway, with the color gradient scaled from low (attenuated capacity) to high (preserved capacity). I want to emphasize that the matrix is simulated. Values were parameterized to reproduce directional trends reported in the literature rather than to represent empirical measurements. The intent is to provide a compact scaffold for discussing pathway and tissue-specific vulnerability, not to assert quantitative effect sizes. The simulated pattern reflects several recurring observations: pronounced decline in double-strand break repair fidelity, particularly HR relative to the more error-prone NHEJ, alongside diminished BER throughput in post-mitotic compartments where oxidative lesion burden accumulates. Neuronal and hematopoietic columns display the steepest attenuation, consistent with reported associations between DDR insufficiency, mutational accumulation, and clonal dynamics. I would welcome critique on the parameterization strategy, particularly the choice to normalize within pathway rather than across tissues, which necessarily obscures absolute cross-pathway baseline differences.
September 6, 2026 at 5:10 PM
freegardener.bsky.social
Our DNA takes thousands of hits daily, and repair crews usually fix them—until they can't. When the fixer fails, aging accelerates. Can we boost #DNARepair #AgingResearch #Longevity #Healthspan

https://freegardner.wordpress.com/2026/09/05/broken-dna-and-the-failing-clock-of-aging/
Broken DNA and the Failing Clock of Aging
Broken DNA and the Failing Clock of Aging
freegardner.wordpress.com
September 5, 2026 at 4:09 AM
tenuretracker.bsky.social
Karolinska Institute (@ki.se) is hiring:
Postdoctoral Studies in DNA Repair and Translational Drug Discovery

#postdoc #medicine #dnarepair
September 4, 2026 at 7:23 PM
wimi-bio-tech.bsky.social
UT Health San Antonio researchers engineered U-report, a CBE/AMBER biosensor that quantifies live-cell chromosomal UNG activity in real time, revealing that mitochondrial UNG1 actively participates in nuclear uracil repair. 🧬🤖 #DNArepair #Ureport #BaseEditing #GenomicStability #Epigenetics
September 1, 2026 at 7:43 AM
nicolocovelli.bsky.social
Preclinical studies using mouse models showed that inhibiting the ATR pathway with elimusertib significantly decreases tumor growth and prolongs progression-free survival.

📄 Source: doi.org/10.1158/0008...

#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy
FET fusion oncoproteins subvert genome maintenance by impairing ATM activity, bridging two key fields—oncogene biology and DNA repair—and proposing ATR inhibition as a targeted therapeutic approach…
doi.org
September 1, 2026 at 10:00 AM