🚨 New Paper 📜 Alert 🚨 Many congratulations 👏 🎉 to Akhona Myoli for publishing her PhD research chapter! The study describes how new metabolomics profiles and computational metabolomics tools uncov...

ASHG 2026 took place in Montréal from 20–24 October 2026, and companies in the NGS and Multiomics space took the opportunity to present updates to their product lines, with a focus on Population Genom...

Single-nucleus chromatin accessibility and transcriptome maps of human skeletal muscle identify cell-state and context-specific QTLs that colocalize with genome-wide association signals for cardiometa...

Applying single-cell multiomics to people at risk of rheumatoid arthritis, Wu, Zhang, Moon and colleagues identify an expansion of activated, senescent-like B cells associated with disease development...

A comparative analysis of multiomics data from embryonic and adult tissues of Atlantic salmon and rainbow trout reveals developmental and tissue-specific constraints shaping regulatory evolution follo...

Extracorporeal liver cross-circulation (ELC) using gene-edited porcine liver xenografts offers a potential bridge therapy for liver failure. We previously performed five ELC procedures in four brain-dead human decedents, during which the recipients developed severe thrombocytopenia. The porcine liver xenografts maintained their parenchymal structure, with immune cell infiltration and detectable IgM deposition on endothelial cells. Here, to investigate the underlying host–xenograft interactions, we performed longitudinal proteomic, lipidomic and metabolomic profiling of 64 blood samples, alongside spatial transcriptomics and histology of 25 porcine liver xenograft and 3 native human liver biopsies. Spatial transcriptomic analysis revealed progressive infiltration of human immune cells (predominantly inflammatory macrophages and neutrophils) in the xenografts, concurrent with the loss of porcine Kupffer-like macrophages and T cells. Distinct human and porcine complement dynamics were obs