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This reveals how RNA-binding proteins activate DNA-damage sensors, opening precise and reversible strategies to bypass tumor resistance.

📄 Source: www.cell.com/molecular-ce...

#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
September 10, 2026 at 10:00 AM
nicolocovelli.bsky.social
#MolecularIntegrity #MolecularBiology #GeneRegulation #GenomeStability #CancerBiology #SciComm
September 8, 2026 at 10:50 AM
nicolocovelli.bsky.social
Preclinical studies using mouse models showed that inhibiting the ATR pathway with elimusertib significantly decreases tumor growth and prolongs progression-free survival.

📄 Source: doi.org/10.1158/0008...

#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy
FET fusion oncoproteins subvert genome maintenance by impairing ATM activity, bridging two key fields—oncogene biology and DNA repair—and proposing ATR inhibition as a targeted therapeutic approach…
doi.org
September 1, 2026 at 10:00 AM
nicolocovelli.bsky.social
👉 Read the full, detailed analysis on Molecular Integrity: molecularintegrity.substack.com/p/the-calciu...

#MolecularBiology #CancerResearch #GeneRegulation #TranslationalMedicine #MolecularIntegrity
How a calcium sensor becomes colorectal cancer's fuel: the role of the HPCAL1-Wnt axis
Exploring the molecular complexes that fuel CRC aggressiveness and the promising role of targeted drug repurposing.
molecularintegrity.substack.com
August 26, 2026 at 6:57 PM