#DNAdamageResponse
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actacrystd.iucr.org
Through extensive classification of a previously deposited cryoEM dataset, a previously unresolved ALC1–nucleosome complex characterized by a more open conformation of ALC1 was identified #DNADamageResponse #ChromatinRemodeling #ALC1 doi.org/10.1107/S205...
August 17, 2026 at 1:46 PM
kuodyte.bsky.social
Excited to share our paper, now out in @jcb.org! 🎉
Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb....
📷by me ❤️
August 4, 2026 at 3:02 PM
tenuretracker.bsky.social
University of North Carolina is hiring:
Post-Doc Research Associate - Vaziri-Bowser labs

#postdoc #biology #dnadamageresponse
September 26, 2026 at 8:45 PM
embo.org
Delve into different aspects of the #DNAdamageResponse at the EMBO Workshop "#Evolution and diversity of the DNA damage response" in Bengaluru, India, 23–27 February 2027.

Deadline: 15 September 2026

https://meetings.embo.org/event/27-dna-damage-response
#EMBOdnadamage #LifeSciences #EMBOevents 🧪
September 7, 2026 at 8:18 AM
cp-trendsbiochem.bsky.social
📝 Online now - the Review "Emerging functions for nonhistone protein acetylation in budding yeast" from Michael Downey and colleagues.

#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation

Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
November 12, 2025 at 2:28 PM
cp-trendsbiochem.bsky.social
📝Now online - the Review "Single-stranded DNA-binding proteins at healthy and diseased telomeres" from Stéphane Coulon, Alexandre Maréchal, and colleagues.

#telomeres #SSBPs #ReplicativeStress #DNADamageResponse #telomeropathies #ALT

Read it here 👉 authors.elsevier.com/a/1mPAN3S6Gf...
January 7, 2026 at 1:53 PM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 9:00 AM
cilialab.bsky.social
We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪
July 29, 2025 at 10:17 AM
embo.org
Delve into different aspects of the #DNAdamageResponse at the EMBO Workshop "#Evolution and diversity of the DNA damage response" in Bengaluru, India, 23–27 February 2027.

Deadline: 15 September 2026

https://meetings.embo.org/event/27-dna-damage-response
#EMBOdnadamage #EMBOevents 🧪
July 22, 2026 at 2:20 PM
majakuzman.bsky.social
#DoOrDie #DNADamageResponse

Thats a cool story :

When a cells DNA is damaged, and needs a quick reaction, its actually the buildup of (errorenous) RNA that through ribosome confusion and bumping into each other actually signals the quick response for apoptosis. Makes a lot of sense.
RNA Is the Cell’s Emergency Alert System | Quanta Magazine
How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals danger.
www.quantamagazine.org
July 14, 2025 at 4:12 PM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 2:02 PM
genesndiseases.bsky.social
Learn how DYRK kinases shape cancer therapy.
This review shows how DYRK proteins regulate #DNADamageResponse and highlights DYRK inhibitors as promising #PrecisionOncology strategies to exploit cancer-specific DNA repair vulnerabilities.
#GenesAndDiseases: doi.org/10.1016/j.ge...
September 13, 2026 at 4:28 AM
genesndiseases.bsky.social
This review highlights the role of #DYRK #kinases in #DNADamageResponse, linking their activity to #cancer progression, while evaluating current DYRK inhibitors and positioning DYRK inhibition as a promising #PrecisionOncology strategy.

#OpenAccess: doi.org/10.1016/j.ge...
March 12, 2026 at 2:15 AM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 4, 2026 at 5:30 PM
alicefrolov.bsky.social
Sharing a heatmap from an ongoing methodological exercise: "Age-associated erosion of DNA repair pathway capacity across human tissues"

#DNArepair #DNAdamageResponse #GenomeInstability #BasexcisionRepair #HomologousRecombination #GenomeMaintenance #Mutagenesis
Sharing a heatmap from an ongoing methodological exercise: "Age-associated erosion of DNA repair pathway capacity across human tissues," with the subtitle "Simulated relative repair activity for six core DNA damage response pathways (young vs aged donors)." The visualization arranges six canonical DNA damage response (DDR) pathways along the vertical axis: base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), non-homologous end joining (NHEJ), and interstrand crosslink repair (the Fanconi anemia pathway). The horizontal axis stratifies representative tissue compartments (hematopoietic, hepatic, dermal, skeletal muscle, cortical neuronal, and intestinal epithelium) in paired young and aged donor columns. Cell values encode relative repair activity normalized within pathway, with the color gradient scaled from low (attenuated capacity) to high (preserved capacity). I want to emphasize that the matrix is simulated. Values were parameterized to reproduce directional trends reported in the literature rather than to represent empirical measurements. The intent is to provide a compact scaffold for discussing pathway and tissue-specific vulnerability, not to assert quantitative effect sizes. The simulated pattern reflects several recurring observations: pronounced decline in double-strand break repair fidelity, particularly HR relative to the more error-prone NHEJ, alongside diminished BER throughput in post-mitotic compartments where oxidative lesion burden accumulates. Neuronal and hematopoietic columns display the steepest attenuation, consistent with reported associations between DDR insufficiency, mutational accumulation, and clonal dynamics. I would welcome critique on the parameterization strategy, particularly the choice to normalize within pathway rather than across tissues, which necessarily obscures absolute cross-pathway baseline differences.
September 6, 2026 at 5:10 PM
currentmedscience.bsky.social
TOPK was overexpressed in patients with moderately to poorly differentiated CRC receiving #Radiotherapy, while its knockdown significantly enhanced the #Radiosensitivity of CRC cells by reducing the #DNAdamageResponse.
Read more: doi.org/10.1007/s115...
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
February 4, 2026 at 3:20 AM
currentmedscience.bsky.social
TOPK is overexpressed in moderately to poorly differentiated #ColorectalCancer, while its inhibition enhances the sensitivity of CRC cells to #Radiotherapy by suppressing the downstream pathways of #DNADamageResponse. #medsky

Read our #MostDownloaded article: link.springer.com/article/10.1...
July 31, 2025 at 4:01 PM
sigtrans-sttt.bsky.social
#DNADamageResponse protein, KIN, drives #ESCC progression by clearing R-loop–associated #DNAdamage, while KIN depletion triggers NFκB–STING activation, improves the #TumorImmuneMicroenvironment, and enhances #immunotherapy response.

#OpenAccess in #STTT: doi.org/10.1038/s413...
November 27, 2025 at 4:40 PM
sigtrans-sttt.bsky.social
This study identifies KIN as a novel R-loop binding protein in #ESCC, that promotes DNA damage clearance and #ImmuneEvasion, while its depletion triggers R-loop accumulation and STING–NFκB–mediated immune activation. #DNADamageResponse

#STTT #OpenAccess:
DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop
doi.org
September 9, 2025 at 12:30 PM
genesndiseases.bsky.social
TOPK is overexpressed in moderately to poorly differentiated #ColorectalCancer, while its inhibition enhances the sensitivity of CRC cells to #Radiotherapy by suppressing the downstream pathways of #DNADamageResponse. #medsky

Read our #MostDownloaded article: link.springer.com/article/10.1...
July 31, 2025 at 4:01 PM