We are still accepting submissions for our upcoming special issue on proteostasis. This issue will be coordinated by Pedro Carvalho and Tamotsu Yoshimori.
Extended submission deadline: 20 November 2026
tinyurl.com/34u9tcj8
Extended submission deadline: 20 November 2026
tinyurl.com/34u9tcj8
November 2, 2026 at 9:52 AM
We are still accepting submissions for our upcoming special issue on proteostasis. This issue will be coordinated by Pedro Carvalho and Tamotsu Yoshimori.
Extended submission deadline: 20 November 2026
tinyurl.com/34u9tcj8
Extended submission deadline: 20 November 2026
tinyurl.com/34u9tcj8
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
November 3, 2026 at 12:30 PM
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
What is the connection between proteostasis and longevity?
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
November 2, 2026 at 8:56 AM
What is the connection between proteostasis and longevity?
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
November 3, 2026 at 2:04 PM
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
What links proteostasis and longevity?
📍 Umeå University
📅 Deadline: Nov 15, 2026
#Postdoc #Proteostasis #Longevity #AgingResearch
📍 Umeå University
📅 Deadline: Nov 15, 2026
#Postdoc #Proteostasis #Longevity #AgingResearch
What is the connection between proteostasis and longevity?
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
This is one of the big questions my lab is currently tackling. We're looking for a #postdoc to take ownership of this project and help uncover novel regulators of proteostasis and aging.
#Proteostasis #AgingResearch #Longevity
November 2, 2026 at 8:57 AM
What links proteostasis and longevity?
📍 Umeå University
📅 Deadline: Nov 15, 2026
#Postdoc #Proteostasis #Longevity #AgingResearch
📍 Umeå University
📅 Deadline: Nov 15, 2026
#Postdoc #Proteostasis #Longevity #AgingResearch
Reprogramming Muscle Proteostasis in Cancer Cachexia: Transcriptional Mechanisms and Therapeutic Opportunities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 4, 2026 at 4:58 PM
Reprogramming Muscle Proteostasis in Cancer Cachexia: Transcriptional Mechanisms and Therapeutic Opportunities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Survey of the human proteostasis network: the autophagy-lysosome pathway
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Survey of the human proteostasis network: the autophagy-lysosome pathway
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a hig...
www.tandfonline.com
October 29, 2026 at 6:22 PM
Survey of the human proteostasis network: the autophagy-lysosome pathway
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Maintaining proteostasis is the province of the proteostasis network, which consists of the ...
www.tandfonline.com
October 29, 2026 at 6:23 PM
Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis
go.nature.com/4e1pmJK
go.nature.com/4e1pmJK
Cold activates a BH2 metabolic network promoting longevity and proteostasis - Nature
A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.
go.nature.com
October 27, 2026 at 1:39 PM
Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis
go.nature.com/4e1pmJK
go.nature.com/4e1pmJK
📝 Conference science meets team spirit! Our second report covers the @plantproteostasis.bsky.social meeting & our lab retreat, from protein turnover to spending time together beyond the bench.🌱♻️🔬 Read about the science, conversations, and fun! 👇
Fast & Flambée-ous: The Üstün Lab Goes to Strasbourg
Fast & Flambée-ous: The Üstün Lab Goes to Strasbourg
Fast & Flambée-ous: The Üstün Lab Goes to Strasbourg
Just one week after our meeting in Málaga, from October 14–16, the Üstün lab was already back on the road — this time heading to Strasbourg for the International Plant Proteostasis Conference, orga…
theustunlab.com
November 3, 2026 at 8:07 AM
📝 Conference science meets team spirit! Our second report covers the @plantproteostasis.bsky.social meeting & our lab retreat, from protein turnover to spending time together beyond the bench.🌱♻️🔬 Read about the science, conversations, and fun! 👇
Fast & Flambée-ous: The Üstün Lab Goes to Strasbourg
Fast & Flambée-ous: The Üstün Lab Goes to Strasbourg
How do cells prevent damaged proteins from becoming harmful? 🧬
At IIMCB, Dr Lidia Wróbel’s team investigates protein quality control and its links to neurodegeneration.
🎬 Meet the Laboratory of Cellular Proteostasis in our new video!
#IIMCB #RACE_HorizonEU #REA_research
At IIMCB, Dr Lidia Wróbel’s team investigates protein quality control and its links to neurodegeneration.
🎬 Meet the Laboratory of Cellular Proteostasis in our new video!
#IIMCB #RACE_HorizonEU #REA_research
November 3, 2026 at 1:38 PM
How do cells prevent damaged proteins from becoming harmful? 🧬
At IIMCB, Dr Lidia Wróbel’s team investigates protein quality control and its links to neurodegeneration.
🎬 Meet the Laboratory of Cellular Proteostasis in our new video!
#IIMCB #RACE_HorizonEU #REA_research
At IIMCB, Dr Lidia Wróbel’s team investigates protein quality control and its links to neurodegeneration.
🎬 Meet the Laboratory of Cellular Proteostasis in our new video!
#IIMCB #RACE_HorizonEU #REA_research
What mechanisms underlie the benefits of moderately cold temperatures, associated w/ delayed aging?
🧪 In Nature, David Vilchez et al. identify a metabolite-driven, multi-tissue signaling system that links cold temperature to enhanced longevity & proteostasis in C. elegans: https://ow.ly/eZ1t5101tno
🧪 In Nature, David Vilchez et al. identify a metabolite-driven, multi-tissue signaling system that links cold temperature to enhanced longevity & proteostasis in C. elegans: https://ow.ly/eZ1t5101tno
!["BH2 synthesis pathway can be leveraged to confer longevity and proteostasis benefits at normal and elevated temperatures in both C. elegans and human cells, researchers say." [Microscopic view of C. elegans worms against a blue and black background.]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:rwlgqcdor35eg4ad7fq256dp/bafkreiefc3sakzysumz32gpdotitrxbbzuxkdfxx4avp63yo5w3ggugkue)
October 30, 2026 at 11:20 PM
What mechanisms underlie the benefits of moderately cold temperatures, associated w/ delayed aging?
🧪 In Nature, David Vilchez et al. identify a metabolite-driven, multi-tissue signaling system that links cold temperature to enhanced longevity & proteostasis in C. elegans: https://ow.ly/eZ1t5101tno
🧪 In Nature, David Vilchez et al. identify a metabolite-driven, multi-tissue signaling system that links cold temperature to enhanced longevity & proteostasis in C. elegans: https://ow.ly/eZ1t5101tno
Cold activates a BH2 metabolic network promoting longevity and proteostasis.
Nature
This week in Parkinson's and Movement Disorders: palamedesreport.org/this-week/movement-disorders
pubmed.ncbi.nlm.nih.gov/42907506
#MedSky #neurology #parkinsons
Nature
This week in Parkinson's and Movement Disorders: palamedesreport.org/this-week/movement-disorders
pubmed.ncbi.nlm.nih.gov/42907506
#MedSky #neurology #parkinsons
November 3, 2026 at 2:00 PM
Cold activates a BH2 metabolic network promoting longevity and proteostasis.
Nature
This week in Parkinson's and Movement Disorders: palamedesreport.org/this-week/movement-disorders
pubmed.ncbi.nlm.nih.gov/42907506
#MedSky #neurology #parkinsons
Nature
This week in Parkinson's and Movement Disorders: palamedesreport.org/this-week/movement-disorders
pubmed.ncbi.nlm.nih.gov/42907506
#MedSky #neurology #parkinsons
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
November 3, 2026 at 12:30 PM
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance https://www.biorxiv.org/content/10.64898/2026.11.02.763615v1
Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: A nanoscale map of the human cell surface proteome reveals spatial and functional organization www.nature.com/articles/s41...
Highlight: A nanoscale map of the human cell surface proteome reveals spatial and functional organization www.nature.com/articles/s41...
bims-proteo 2026-11-01 papers
biomed.news
November 1, 2026 at 6:26 AM
Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: A nanoscale map of the human cell surface proteome reveals spatial and functional organization www.nature.com/articles/s41...
Highlight: A nanoscale map of the human cell surface proteome reveals spatial and functional organization www.nature.com/articles/s41...
What Can AI Agents Do for Proteostasis Research?
Join Mathieu Bourdenx (UK Dementia Research Institute, UCL) for an insight into the opportunities and applications of AI in the proteostasis field.
📅 25 Nov 2026
⏰ 3-4 pm (GMT)
💻 Online
👉 Register here: events.teams.microsoft.com/event/8a1806...
Join Mathieu Bourdenx (UK Dementia Research Institute, UCL) for an insight into the opportunities and applications of AI in the proteostasis field.
📅 25 Nov 2026
⏰ 3-4 pm (GMT)
💻 Online
👉 Register here: events.teams.microsoft.com/event/8a1806...
November 2, 2026 at 4:56 PM
What Can AI Agents Do for Proteostasis Research?
Join Mathieu Bourdenx (UK Dementia Research Institute, UCL) for an insight into the opportunities and applications of AI in the proteostasis field.
📅 25 Nov 2026
⏰ 3-4 pm (GMT)
💻 Online
👉 Register here: events.teams.microsoft.com/event/8a1806...
Join Mathieu Bourdenx (UK Dementia Research Institute, UCL) for an insight into the opportunities and applications of AI in the proteostasis field.
📅 25 Nov 2026
⏰ 3-4 pm (GMT)
💻 Online
👉 Register here: events.teams.microsoft.com/event/8a1806...
A paper in Nature reports that moderate cold activates a muscle-derived BH2/BH4/tyrosine pathway that improves proteostasis and lifespan in C. elegans. Human-cell data suggest conserved proteostasis effects, but longevity effects have not been tested beyond worms.🧪 www.nature.com/articles/s41...
Cold activates a BH2 metabolic network promoting longevity and proteostasis - Nature
A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.
www.nature.com
October 28, 2026 at 1:02 PM
A paper in Nature reports that moderate cold activates a muscle-derived BH2/BH4/tyrosine pathway that improves proteostasis and lifespan in C. elegans. Human-cell data suggest conserved proteostasis effects, but longevity effects have not been tested beyond worms.🧪 www.nature.com/articles/s41...
Survey of the human proteostasis network: the ubiquitin-proteasome system
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Survey of the human proteostasis network: the ubiquitin-proteasome system
Modification by ubiquitination governs the half-lives of thousands of proteins that are fated for elimination by either the proteasome or autophagy pathways, depending on the intricate architecture...
www.tandfonline.com
October 29, 2026 at 6:24 PM
Survey of the human proteostasis network: the ubiquitin-proteasome system
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Tomato SlNAC3 regulates proteostasis in response to early cold stress (Lunda Wei , Ying Chen , Tao Wang , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
Tomato SlNAC3 regulates proteostasis in response to early cold stress
Abstract. Cold stress poses a significant challenge to tomato production. SlNAC3, an NAC (NAM, ATAF1/2, and CUC2) transcription factor in tomato, plays a c
doi.org
October 28, 2026 at 8:09 PM
Tomato SlNAC3 regulates proteostasis in response to early cold stress (Lunda Wei , Ying Chen , Tao Wang , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
New review with @resiapretorius.bsky.social of amyloid in atherosclerotic and other plaques, explaining why they remain link.springer.com/article/10.1...
Atherosclerosis as a localised amyloid and proteostasis disorder - Cellular and Molecular Life Sciences
Atherosclerotic plaques cause many acute cardiovascular events, including myocardial infarction and ischaemic stroke. Diseases of this type are effectively the leading causes of death worldwide. Plaqu...
link.springer.com
October 30, 2026 at 2:19 PM
New review with @resiapretorius.bsky.social of amyloid in atherosclerotic and other plaques, explaining why they remain link.springer.com/article/10.1...
Chloé Rivière, Gabriel Publicola, Alexandre Stella, Odile Burlet-Schiltz, Jérôme Nigou, Michel Rivière: Dynamic membrane organization coordinates protein-O-mannosylation and proteostasis in mycobacteria https://hal.science/hal-05845083v1 [sdv]
November 2, 2026 at 3:01 AM
Chloé Rivière, Gabriel Publicola, Alexandre Stella, Odile Burlet-Schiltz, Jérôme Nigou, Michel Rivière: Dynamic membrane organization coordinates protein-O-mannosylation and proteostasis in mycobacteria https://hal.science/hal-05845083v1 [sdv]
Jasmine Castellanos and Khanh Nguyen led this work, in collaboration with Wei Shi and @pskcellbio.bsky.social, and it can be found on BiorXiv:
www.biorxiv.org/content/10.6...
6/6
www.biorxiv.org/content/10.6...
6/6
N-terminal Trimming Supports Proteostasis Under Secretory Protein Mislocalization Stress
Secretory proteins that fail to enter the endoplasmic reticulum (ER) are mislocalized to the cytosol, where they threaten cellular proteostasis. How cells manage these mislocalized proteins remains po...
www.biorxiv.org
November 1, 2026 at 11:45 PM
Jasmine Castellanos and Khanh Nguyen led this work, in collaboration with Wei Shi and @pskcellbio.bsky.social, and it can be found on BiorXiv:
www.biorxiv.org/content/10.6...
6/6
www.biorxiv.org/content/10.6...
6/6
🌱 It was a pleasure sharing updates on our research in protein import into chloroplasts and its regulation by the ubiquitin-proteasome system at the 5th International Conference on Plant Proteostasis in Strasbourg. Until next time!
October 28, 2026 at 7:59 AM
🌱 It was a pleasure sharing updates on our research in protein import into chloroplasts and its regulation by the ubiquitin-proteasome system at the 5th International Conference on Plant Proteostasis in Strasbourg. Until next time!
We found that cells survive a proteostasis defect, but not the lipid imbalance it causes. Rer1 & the Dsc complex triage orphan membrane proteins at the Golgi. Lose both & DAG-rich multilamellar compartments (DMCs) form. Drain DAG & cellular architecture recovers.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
October 27, 2026 at 10:51 AM
We found that cells survive a proteostasis defect, but not the lipid imbalance it causes. Rer1 & the Dsc complex triage orphan membrane proteins at the Golgi. Lose both & DAG-rich multilamellar compartments (DMCs) form. Drain DAG & cellular architecture recovers.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Cold Triggers a Hidden Molecular Pathway That Extends Lifespan, Study Finds www.nature.com/articles/s41...
Cold activates a BH2 metabolic network promoting longevity and proteostasis - Nature
A multi-tissue signalling system links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans.
www.nature.com
October 30, 2026 at 4:39 PM
Cold Triggers a Hidden Molecular Pathway That Extends Lifespan, Study Finds www.nature.com/articles/s41...