#HIV1
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ninjagoshow.bsky.social
"The tide of what is to come cannot be turned back..."

youtube.com/watch?v=hiV1...

#LEGO #LEGONinjago #Ninjago #NinjagoLegends #NinjagoLegendsDuskfall
July 24, 2026 at 7:53 PM
lousadzak.bsky.social
Wait, is it classifying worms and viruses together because the terms co-occur in the context of computing
A portion of a tree diagram that shows “worm” as one leaf, with a branch next to it containing “sarscov2” and “hiv1”
May 20, 2026 at 6:52 AM
godswrath699.bsky.social
youtube.com/watch?v=hIv1...

Luke Beasley
OH DAMN: Trump SHOCKED as Newsom Presser HITS HIM HARD!
YouTube video by Luke Beasley
youtube.com
April 18, 2025 at 3:58 AM
fob83.bsky.social
1983 scoperta della SINDROME DA IMMUNODEFICENZA ACQUISITA "AIDS"
2026 esiste gente che non sà che:
•AIDS acronimo del nome malattia
•HIV acronimo del nome del patogeno che causa AIDS
•HIV1 e HIV2 acronimo del nome usata per differenziare i due ceppi del patogeno.
•Non sa come ci si contagia
May 8, 2026 at 7:36 PM
milofasken.bsky.social
Cool!
#HIV1 #Rev #CRM1 #RRE
December 3, 2024 at 2:01 PM
apapi84.bsky.social
Mi mancava la doppia versione di HIV, HIV1 e HIV2. Quando lo studiai alle superiori all’epoca non me ne avevano parlato.😕
fob83.bsky.social Fob @fob83.bsky.social · May 8
1983 scoperta della SINDROME DA IMMUNODEFICENZA ACQUISITA "AIDS"
2026 esiste gente che non sà che:
•AIDS acronimo del nome malattia
•HIV acronimo del nome del patogeno che causa AIDS
•HIV1 e HIV2 acronimo del nome usata per differenziare i due ceppi del patogeno.
•Non sa come ci si contagia
May 19, 2026 at 8:12 AM
milofasken.bsky.social
Beautiful work! RRE binds CRM1. Wow! 😊
#HIV1 #Rev #RRE #CRM1 #Exportin1 #Ran

www.cell.com/molecular-ce...
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition
The HIV nuclear export complex shows that CRM1 recognizes diverse cargos through distinct sites, utilizing multipartite recognition via the NES and additional protein and RNA contacts. A unique CRM1 d...
www.cell.com
August 22, 2025 at 1:15 PM
whatleydude.com
I'm in Denmark this week, doing Minecrafty things and tending to some Ninjago-y things.

I still cannot believe I get to work on this:

NINJAGO LEGENDS DUSKFALL

www.youtube.com/watch?v=hiV1...
🚨⚡️NEW Trailer! | LEGO NINJAGO: Legends DuskFall | Coming Soon | LEGO
YouTube video by LEGO
www.youtube.com
August 4, 2026 at 5:28 PM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 9:00 AM
milofasken.bsky.social
Interesting!
#HIV1 #RNA #Rev #MTR4 #MATR3
www.nature.com/articles/s41...
Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency - Nature Communications
In their study, Dorman and Bendoumou et al., reveal a post-transcriptional regulation of unspliced HIV-1 RNA by host factors MATR3, MTR4, and the viral protein Rev, identifying a previously uncharacte...
www.nature.com
March 1, 2025 at 8:54 PM
cyrilpedia.bsky.social
'there are reports that HIV2 infection can reduce HIV1-associated pathogenesis in dual-infected patients & cell culture. However, the mechanisms underlying these protective effects are not well understood. To decipher these mechanisms, we performed dual infections with HIV1 & HIV2 in cell culture'
HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection | J...
Twenty-five years after the first report that HIV-2 infection can reduce HIV-1-associated pathogenesis in dual-infected patients, the mechanisms are still not well understood. We explored these mechan...
journals.asm.org
December 2, 2023 at 11:24 AM
brynnthomas.bsky.social
#OTILT Fostemsavir is HIV1 attachment inhibitor, a relatively new class of antiretrovirals, for multidrug-resistant HIV1. It doesn't show cross-resistance with other antiretrovirals and can be added onto optimized background therapy for patients with limited options. @bwdionne.bsky.social
May 30, 2025 at 4:47 PM
viruswench.bsky.social
I always forget about bluesky, but hello fellow virus people and democracy seekers! 🩵🦇

As for life updates, I’m starting some work on HIV1 reservoirs and totally clueless. Any lenti or HIV people, I would love to know your must-read papers/books!
November 6, 2025 at 3:03 AM
aixbiobot.bsky.social
Machine Learning Prediction of HIV1 Drug Resistance against Integrase Strand Transfer Inhibitors [new]
HIV integrase INSTI resistance prediction: Logistic Regression, key sequence features ID.
Machine Learning Prediction of HIV1 Drug Resistance against Integrase Strand Transfer Inhibitors Figure 1 Figure 2 Figure 3
April 29, 2025 at 2:26 PM
biorxiv-bioinfo.bsky.social
Machine Learning Prediction of HIV1 Drug Resistance against Integrase Strand Transfer Inhibitors https://www.biorxiv.org/content/10.1101/2025.04.25.650610v1
April 29, 2025 at 2:11 PM
biorxivpreprint.bsky.social
Machine Learning Prediction of HIV1 Drug Resistance against Integrase Strand Transfer Inhibitors https://www.biorxiv.org/content/10.1101/2025.04.25.650610v1
April 29, 2025 at 2:11 PM
plosbiology.org
Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @plosbiology.org 🧪 plos.io/45VTGBR
Left: Immunofluorescence analysis of PMA-differentiated THP-1 parental (control) macrophages infected with Lai∆envGFP/G (WT, M10, or WT in the presence of RT inhibitor (EFV), MOI 1), and stained with anti-dsRNA (J2) antibody. The establishment of productive HIV-1 infection in THP1/PMA macrophages was visualized by GFP expression, and nucleus is stained with DAPI. The white arrowheads indicate positive staining of dsRNA puncta. Scale bar represents 5 μm. Right: Schematic of the diversity of cytosolic HIV-1 icRNA sensing and innate immune activation pathways in myeloid cells. Image was created in BioRender.
September 9, 2025 at 9:30 AM
viruswench.bsky.social
I have over 2 years of research experience in various areas of virology, and I am currently finishing out my senior thesis work analyzing snRNAseq data from HIV+ donor tissues to find new HIV1 reservoir tissues, as well as working on molecular therapies for HIV reservoirs.

🦠🦠🦠🦠🦠
January 2, 2026 at 4:03 PM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 2:02 PM
thehdroom.bsky.social
Ninjago's 15th Anniversary celebration continues with the reveal of Duskfall, an aged-up Legends canon story coming in September.
www.youtube.com/watch?v=hiV1...
July 24, 2026 at 6:15 PM
cindotx.bsky.social
youtube.com/watch?v=hIv1...
OH DAMN: Trump SHOCKED as Newsom Presser HITS HIM HARD!
YouTube video by Luke Beasley
youtube.com
April 18, 2025 at 3:50 AM
plosbiology.org
Latent HIV-1 resists current #reactivation therapies, hindering viral eradication. This study identifies #RNAbindingProtein RBM39 as a scaffold assembling an m⁶A-dependent RNA decay complex that degrades Tat transcripts, enforcing & maintaining #HIV1 latency @plosbiology.org 🧪 plos.io/4nRrHsO
A schematic diagram showing two models of HIV-1 infection. Left panel (HIV-1 latency model): Under HIV-1 infection, upregulated RBM39 promotes m⁶A methylation of Tat RNA. This modification is recognized by YTHDC1, which subsequently recruits the RNA helicase DDX5 to degrade m⁶A-methylated Tat RNA. As a result, Tat RNA fails to undergo splicing and translation into functional Tat protein, thereby preventing activation of the HIV-1 LTR promoter and maintaining viral latency. Right panel (HIV-1 reactivation model): Treatment with indisulam induces degradation of RBM39. This abolishes the recognition of Tat RNA by YTHDC1 and its degradation by DDX5. Consequently, Tat RNA is efficiently translated into Tat protein, which activates the HIV-1 LTR promoter, leading to HIV-1 reactivation.
November 12, 2025 at 5:35 PM
comixfan.bsky.social
www.youtube.com/watch?v=hIV1...
⊗🧟More Snap Zombies🧟 then 🪽more Rivals ranked🪽 with ex-Marvel writer Comixfan! ⊗
YouTube video by Comi⊗fan
www.youtube.com
October 10, 2025 at 4:55 AM
plosbiology.org
Latent HIV-1 resists current #reactivation therapies, hindering viral eradication. This study identifies #RNAbindingProtein RBM39 as a scaffold assembling an m⁶A-dependent RNA decay complex that degrades Tat transcripts, enforcing & maintaining #HIV1 latency @plosbiology.org 🧪 plos.io/4nRrHsO
A schematic diagram showing two models of HIV-1 infection. Left panel (HIV-1 latency model): Under HIV-1 infection, upregulated RBM39 promotes m⁶A methylation of Tat RNA. This modification is recognized by YTHDC1, which subsequently recruits the RNA helicase DDX5 to degrade m⁶A-methylated Tat RNA. As a result, Tat RNA fails to undergo splicing and translation into functional Tat protein, thereby preventing activation of the HIV-1 LTR promoter and maintaining viral latency. Right panel (HIV-1 reactivation model): Treatment with indisulam induces degradation of RBM39. This abolishes the recognition of Tat RNA by YTHDC1 and its degradation by DDX5. Consequently, Tat RNA is efficiently translated into Tat protein, which activates the HIV-1 LTR promoter, leading to HIV-1 reactivation.
November 12, 2025 at 2:05 PM
infdiseasesnow.bsky.social
[Publication Vol 56 - N°1] The first issue of 2026 of "Infectious Diseases Now" is now available.

➡️ www.sciencedirect.com/journal/infe...

#IDsky #Articles #InfectiousDiseases #HumanMetapneumovirus #TickBorneEncephalitis #HumanParainfluenzaVirus #Tuberculosis #HIV1 #AI #Vaccination
January 2, 2026 at 8:53 AM