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genesdev.bsky.social
RESEARCH PAPER: ELAV mediates circular RNA biogenesis in neurons
By Alfonso-Gonzalez et al.
➡️ https://tinyurl.com/gd352670

#circRNA #neuroscience #RNAbindingprotein #Drosophila #embryos #neurons #mRNA #introns #splicing
September 9, 2025 at 3:03 PM
gbmev.bsky.social
"RNA-Binding Proteins in Disease" - 8th Biennial Meeting of the LARP Society from September 2-4th 2026, University of Regensburg, Germany". @meisterlab.bsky.social @sarahblagden.bsky.social
#RNAbindingProtein #science #conference
March 30, 2026 at 12:25 PM
neurodegeneration.bsky.social
RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage.

https://pubmed.ncbi.nlm.nih.gov/40410171/

#neurodegeneration #RNAbindingprotein
May 24, 2025 at 12:34 PM
plosbiology.org
Latent HIV-1 resists current #reactivation therapies, hindering viral eradication. This study identifies #RNAbindingProtein RBM39 as a scaffold assembling an m⁶A-dependent RNA decay complex that degrades Tat transcripts, enforcing & maintaining #HIV1 latency @plosbiology.org 🧪 plos.io/4nRrHsO
A schematic diagram showing two models of HIV-1 infection. Left panel (HIV-1 latency model): Under HIV-1 infection, upregulated RBM39 promotes m⁶A methylation of Tat RNA. This modification is recognized by YTHDC1, which subsequently recruits the RNA helicase DDX5 to degrade m⁶A-methylated Tat RNA. As a result, Tat RNA fails to undergo splicing and translation into functional Tat protein, thereby preventing activation of the HIV-1 LTR promoter and maintaining viral latency. Right panel (HIV-1 reactivation model): Treatment with indisulam induces degradation of RBM39. This abolishes the recognition of Tat RNA by YTHDC1 and its degradation by DDX5. Consequently, Tat RNA is efficiently translated into Tat protein, which activates the HIV-1 LTR promoter, leading to HIV-1 reactivation.
November 12, 2025 at 5:35 PM
neurodegeneration.bsky.social
Small molecule inhibitors of hnRNPA2B1-RNA interactions reveal a predictable sorting of RNA subsets into extracellular vesicles - PubMed

https://pubmed.ncbi.nlm.nih.gov/40103230/

#neurodegeneration #RNAbindingprotein #APP
March 19, 2025 at 2:42 PM
plosbiology.org
Latent HIV-1 resists current #reactivation therapies, hindering viral eradication. This study identifies #RNAbindingProtein RBM39 as a scaffold assembling an m⁶A-dependent RNA decay complex that degrades Tat transcripts, enforcing & maintaining #HIV1 latency @plosbiology.org 🧪 plos.io/4nRrHsO
A schematic diagram showing two models of HIV-1 infection. Left panel (HIV-1 latency model): Under HIV-1 infection, upregulated RBM39 promotes m⁶A methylation of Tat RNA. This modification is recognized by YTHDC1, which subsequently recruits the RNA helicase DDX5 to degrade m⁶A-methylated Tat RNA. As a result, Tat RNA fails to undergo splicing and translation into functional Tat protein, thereby preventing activation of the HIV-1 LTR promoter and maintaining viral latency. Right panel (HIV-1 reactivation model): Treatment with indisulam induces degradation of RBM39. This abolishes the recognition of Tat RNA by YTHDC1 and its degradation by DDX5. Consequently, Tat RNA is efficiently translated into Tat protein, which activates the HIV-1 LTR promoter, leading to HIV-1 reactivation.
November 12, 2025 at 2:05 PM
plosbiology.org
‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL
AlphaFold model of the complex formed between HK2 and the SOX10 5′UTR (189–204 nts). The predicted RNA structure is shown in cyan, and HK2 protein is shown in green. HK2 residues and SOX10 mRNA nucleotides at the interaction interface are highlighted in red. Inset: schematic representation of the secondary structure of the SOX10 5′UTR (189–204 nts) predicted by Mfold, with the putative HK2-binding region (194–198 nts) marked in red.
September 19, 2025 at 8:09 AM
plosbiology.org
‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL
AlphaFold model of the complex formed between HK2 and the SOX10 5′UTR (189–204 nts). The predicted RNA structure is shown in cyan, and HK2 protein is shown in green. HK2 residues and SOX10 mRNA nucleotides at the interaction interface are highlighted in red. Inset: schematic representation of the secondary structure of the SOX10 5′UTR (189–204 nts) predicted by Mfold, with the putative HK2-binding region (194–198 nts) marked in red.
September 18, 2025 at 1:13 PM
plosbiology.org
Latent HIV-1 resists current #reactivation therapies, hindering viral eradication. This study identifies #RNAbindingProtein RBM39 as a scaffold assembling an m⁶A-dependent RNA decay complex that degrades Tat transcripts, enforcing & maintaining #HIV1 latency @plosbiology.org 🧪 plos.io/4nRrHsO
A schematic diagram showing two models of HIV-1 infection. Left panel (HIV-1 latency model): Under HIV-1 infection, upregulated RBM39 promotes m⁶A methylation of Tat RNA. This modification is recognized by YTHDC1, which subsequently recruits the RNA helicase DDX5 to degrade m⁶A-methylated Tat RNA. As a result, Tat RNA fails to undergo splicing and translation into functional Tat protein, thereby preventing activation of the HIV-1 LTR promoter and maintaining viral latency. Right panel (HIV-1 reactivation model): Treatment with indisulam induces degradation of RBM39. This abolishes the recognition of Tat RNA by YTHDC1 and its degradation by DDX5. Consequently, Tat RNA is efficiently translated into Tat protein, which activates the HIV-1 LTR promoter, leading to HIV-1 reactivation.
November 13, 2025 at 8:55 AM
immagina.bsky.social
For the month of July get to know Amina, PhD student from the RBP ReguNet-MSCA Network. Amina joined Immagina in the beginning of last year and integrated the R&D team since 👩‍🔬🔬Learn more about her 👇

#employeespotlight #ribosome #RNAbindingprotein
July 7, 2025 at 12:59 PM
plosbiology.org
Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org 🧪 plos.io/3ViI1qL
AlphaFold model of the complex formed between HK2 and the SOX10 5′UTR (189–204 nts). The predicted RNA structure is shown in cyan, and HK2 protein is shown in green. HK2 residues and SOX10 mRNA nucleotides at the interaction interface are highlighted in red. Inset: schematic representation of the secondary structure of the SOX10 5′UTR (189–204 nts) predicted by Mfold, with the putative HK2-binding region (194–198 nts) marked in red.
September 17, 2025 at 4:44 PM
grnfluoresceblg.bsky.social
This looks like a very interesting #preprint @biorxiv-cellbio.bsky.social from Christine Mayr lab:

"The FXR1 network acts as signaling scaffold for actomyosin remodeling"
🧬#RNA #mRNA #RNABindingProtein #microscopy 🔬

www.biorxiv.org/content/10.1...
November 6, 2023 at 3:48 PM
neurodegeneration.bsky.social
[BioRxiv] RBProximity-CLIP Enables Subcellular Mapping of RNA-Binding Protein Interactions at Nucleotide Resolution

https://doi.org/10.64898/2025.12.12.693770

#neurodegeneration #biorxiv #RNAbindingprotein
BioRxiv Article
doi.org
December 16, 2025 at 4:27 AM
neurodegeneration.bsky.social
[BioRxiv] Native, full-length, refolding-assisted purification of TDP-43 compatible with BSL-2 safety regulations

https://doi.org/10.64898/2025.12.10.693404

#neurodegeneration #biorxiv #Dementia #ALS #RNAbindingprotein
BioRxiv Article
doi.org
December 16, 2025 at 4:26 AM
neurodegeneration.bsky.social
[BioRxiv] RNA modulates FUS condensate assembly, dynamics, and aggregation through diverse molecular contacts

https://doi.org/10.64898/2025.12.13.694118

#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
neurodegeneration.bsky.social
[BioRxiv] ALS/FTD-associated TDP-43 mutations promote fragility of genes governing excitatory neurotransmission via topoisomerase IIβ impairment

https://doi.org/10.64898/2025.12.08.693088

#neurodegeneration #biorxiv #ALS #RNAbindingprotein #Dementia
BioRxiv Article
doi.org
December 12, 2025 at 12:25 AM
neurodegeneration.bsky.social
[BioRxiv] Molecular Visualization of Neuronal TDP43 Pathology In Situ

https://doi.org/10.1101/2024.08.19.608477

#neurodegeneration #biorxiv #ALS #RNAbindingprotein
BioRxiv Article
doi.org
December 3, 2025 at 11:09 PM
neurodegeneration.bsky.social
Functional prediction of DNA/RNA-binding proteins by deep learning from gene expression correlations

https://www.biorxiv.org/content/10.1101/2025.03.03.641203v2

#neurodegeneration #RNAbindingprotein
March 25, 2025 at 7:02 PM
neurodegeneration.bsky.social
Profiling local translatomes and RNA binding proteins of somatosensory neurons reveals specializations of individual axons | bioRxiv

https://www.biorxiv.org/content/10.1101/2025.02.28.640799v1

#neurodegeneration #ALS #RNAbindingprotein
March 18, 2025 at 10:00 PM
genesndiseases.bsky.social
This review shows how #FMRP, a versatile #RNAbindingProtein, drives tumor proliferation, metastasis, & therapy resistance by regulating RNA metabolism, while identifying FMRP-controlled targets as potential clinical interventions.

#OpenAccess: doi.org/10.1016/j.ge...
March 23, 2026 at 11:54 AM