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neurodegeneration.bsky.social
CareALS+
@neurodegeneration.bsky.social
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neurodegeneration.bsky.social
CareALS+ @neurodegeneration.bsky.social · Mar 26
CareALS+ Capsules on Spotify:
A podcast by CareALS+ dedicated to raising awareness and sharing the latest updates in neurodegenerative disease biology.

#neurodegeneration #podcast #CareALS+
CareALS+ Capsules
Podcast · CareALS+ · CareALS+ is an emerging online platform dedicated to raising awareness about ALS and other severe neurodegenerative diseases (collectively referred to as ALS+). Our mission is to ...
open.spotify.com
neurodegeneration.bsky.social
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration | Science www.science.org/doi/10.1126/...

--> One step closer in search of a cure to ALS.

#ALS #neurodegeneration #Cure
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...
www.science.org
June 6, 2026 at 4:07 PM
neurodegeneration.bsky.social
[BioRxiv] Retrotransposon Activation in the Aged and Alzheimer's Disease Brain Examined by Nanopore Long-read DNA Sequencing

https://doi.org/10.64898/2025.12.12.693943

#neurodegeneration #biorxiv #Alzheimers
BioRxiv Article
doi.org
December 16, 2025 at 4:27 AM
neurodegeneration.bsky.social
[BioRxiv] RBProximity-CLIP Enables Subcellular Mapping of RNA-Binding Protein Interactions at Nucleotide Resolution

https://doi.org/10.64898/2025.12.12.693770

#neurodegeneration #biorxiv #RNAbindingprotein
BioRxiv Article
doi.org
December 16, 2025 at 4:27 AM
neurodegeneration.bsky.social
[BioRxiv] Native, full-length, refolding-assisted purification of TDP-43 compatible with BSL-2 safety regulations

https://doi.org/10.64898/2025.12.10.693404

#neurodegeneration #biorxiv #Dementia #ALS #RNAbindingprotein
BioRxiv Article
doi.org
December 16, 2025 at 4:26 AM
neurodegeneration.bsky.social
[BioRxiv] Degraded sensory coding in a mouse model of Scn2a-related disorder and its rescue by CRISPRa gene activation

https://doi.org/10.64898/2025.12.13.694145

#neurodegeneration #biorxiv #biomarker #CRISPR
BioRxiv Article
doi.org
December 16, 2025 at 4:26 AM
neurodegeneration.bsky.social
[BioRxiv] Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntingtons disease

https://doi.org/10.64898/2025.12.11.693749

#neurodegeneration #biorxiv #Neurodegeneration
BioRxiv Article
doi.org
December 16, 2025 at 4:26 AM
neurodegeneration.bsky.social
[BioRxiv] Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived models

https://doi.org/10.64898/2025.12.11.693582

#neurodegeneration #biorxiv #amyloidbeta #amyloid
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
neurodegeneration.bsky.social
[BioRxiv] RNA modulates FUS condensate assembly, dynamics, and aggregation through diverse molecular contacts

https://doi.org/10.64898/2025.12.13.694118

#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
neurodegeneration.bsky.social
[BioRxiv] Temporal Dynamics of High-Frequency Oscillations in Alzheimer's Disease: A Longitudinal Study in hAPP-J20 Mice

https://doi.org/10.64898/2025.12.10.693578

#neurodegeneration #biorxiv #amyloid #Alzheimers
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
neurodegeneration.bsky.social
[BioRxiv] Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

https://doi.org/10.64898/2025.12.10.693468

#neurodegeneration #biorxiv #antisenseoligonucleotides #Alzheimers #ASO #Neurodegeneration
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
neurodegeneration.bsky.social
[BioRxiv] Tau oligomer heterogeneity and associated protein profile in slowly versus rapidly progressive Alzheimer's disease

https://doi.org/10.64898/2025.12.10.693456

#neurodegeneration #biorxiv #Alzheimers
BioRxiv Article
doi.org
December 16, 2025 at 4:24 AM
neurodegeneration.bsky.social
[BioRxiv] Tracking gene expression of single mitochondria in live neurons using nanotweezers

https://doi.org/10.64898/2025.12.10.693488

#neurodegeneration #biorxiv #Neurodegeneration
BioRxiv Article
doi.org
December 16, 2025 at 4:24 AM
neurodegeneration.bsky.social
[BioRxiv] Reduction of Aβ25-35-Induced Cognitive Impairments in C57BL/6 Mice Through Focused Ultrasound Thermal-Cycling Stimulation

https://doi.org/10.64898/2025.12.10.693347

#neurodegeneration #biorxiv #amyloid #oxidativestress
BioRxiv Article
doi.org
December 16, 2025 at 4:24 AM
neurodegeneration.bsky.social
[BioRxiv] Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry

https://doi.org/10.64898/2025.12.12.693871

#neurodegeneration #biorxiv #Alzheimers
BioRxiv Article
doi.org
December 16, 2025 at 4:24 AM
neurodegeneration.bsky.social
[BioRxiv] Reconstructing developmental and disease progression with sample-level embeddings

https://doi.org/10.64898/2025.12.10.693462

#neurodegeneration #biorxiv #Neurodegeneration
BioRxiv Article
doi.org
December 16, 2025 at 4:23 AM
neurodegeneration.bsky.social
[BioRxiv] Mapping the circulating proteome across neurodegeneration: A harmonized, consortium-scale framework for uncovering molecular pathophysiology

https://doi.org/10.64898/2025.12.09.693329

#neurodegeneration #biorxiv #biomarker #Neurodegeneration #Dementia #ALS
BioRxiv Article
doi.org
December 16, 2025 at 4:23 AM
neurodegeneration.bsky.social
[BioRxiv] Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS

https://doi.org/10.64898/2025.12.09.693234

#neurodegeneration #biorxiv #biomarker #ALS
BioRxiv Article
doi.org
December 16, 2025 at 4:23 AM
neurodegeneration.bsky.social
[BioRxiv] Phase Behavior of TDP-43 and hnRNP H1: From Soluble and Aggregated States to Liquid-Like Droplets

https://doi.org/10.1101/2025.11.12.687994

#neurodegeneration #biorxiv #phaseseparation #aggregate
BioRxiv Article
doi.org
December 16, 2025 at 4:22 AM
neurodegeneration.bsky.social
[BioRxiv] Shift in motor-state equilibrium explains gait therapy effects of apomorphine in experimental Parkinsonism

https://doi.org/10.1101/2025.09.07.673890

#neurodegeneration #biorxiv #Parkinsons
BioRxiv Article
doi.org
December 16, 2025 at 4:22 AM
neurodegeneration.bsky.social
Cross-domain Fisher criterion for remote therapeutic efficacy assessment of Parkinson's disease via speech recognition.

https://pubmed.ncbi.nlm.nih.gov/41396313/

#neurodegeneration #pubmed #Parkinsons
Cross-domain Fisher criterion for remote therapeutic efficacy assessment of Parkinson's disease via speech recognition - PubMed
To address the limitation that prevailing cross-domain Parkinson's disease (PD) speech recognition methods mitigate small-sample issues via distribution matching while disregarding substantial feature
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:19 AM
neurodegeneration.bsky.social
Insight into the Neuroprotective Mechanisms of Resveratrol: Inhibition of Alpha-Synuclein Fibrillation and its Role in Mitigating Toxicity.

https://pubmed.ncbi.nlm.nih.gov/41396370/

#neurodegeneration #pubmed #neuroprotective
Insight into the Neuroprotective Mechanisms of Resveratrol: Inhibition of Alpha-Synuclein Fibrillation and its Role in Mitigating Toxicity - PubMed
Insight into the Neuroprotective Mechanisms of Resveratrol: Inhibition of Alpha-Synuclein Fibrillation and its Role in Mitigating Toxicity
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:19 AM
neurodegeneration.bsky.social
Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.

https://pubmed.ncbi.nlm.nih.gov/41396689/

#neurodegeneration #pubmed #Alzheimers #neuroprotective #Parkinsons
Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases - PubMed
Alzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological featu
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:19 AM
neurodegeneration.bsky.social
What can vowel acoustics reveal about the communicative participation of people living with ALS?

https://pubmed.ncbi.nlm.nih.gov/41396714/

#neurodegeneration #pubmed #ALS
What can vowel acoustics reveal about the communicative participation of people living with ALS? - PubMed
<span><i>Objective</i>: Bulbar dysfunction often diminishes the accuracy and speed of the tongue, lip, and jaw movements necessary for speech production. Vowel acoustic features derived from speech re
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:19 AM
neurodegeneration.bsky.social
Investigating the Effectiveness of Haptic Resistive Force Feedback to Improve Tremors in Parkinson's Disease: A Training Impact Study.

https://pubmed.ncbi.nlm.nih.gov/41396751/

#neurodegeneration #pubmed #Parkinsons
Investigating the Effectiveness of Haptic Resistive Force Feedback to Improve Tremors in Parkinson's Disease: A Training Impact Study - PubMed
The goal of this study was to investigate the effectiveness of haptic resistive force feedback in improving the upper limb tremors in Parkinson's Disease (PD) during a button push task. We developed a
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:19 AM
neurodegeneration.bsky.social
Abnormal Large-Scale Dynamic Brain Networks in Parkinson's Disease with Cognitive Impairment: Insights from EEG Co-Activation Patterns.

https://pubmed.ncbi.nlm.nih.gov/41396773/

#neurodegeneration #pubmed #Parkinsons
Abnormal Large-Scale Dynamic Brain Networks in Parkinson's Disease with Cognitive Impairment: Insights from EEG Co-Activation Patterns - PubMed
This study investigated the large-scale dynamic brain network mechanisms underlying cognitive decline in Parkinson's disease (PD) by integrating high-density Electroencephalography (EEG) signal source
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 4:18 AM